Severe loss of function at this locus causes embryonic lethality. Mice homozygous for a hypomorphic ENU-induced allele exhibit thrombocytopenia due to impaired megakaryocyte maturation and platelet shedding, and develop autoinflammatory disease associated with defects in neutrophil function.
|InterPro||IPR020472||G-protein beta WD-40 repeat|
|InterPro||IPR011045||Nitrous oxide reductase, N-terminal|
|InterPro||IPR019775||WD40 repeat, conserved site|
|InterPro||IPR015943||WD40/YVTN repeat-like-containing domain|
|Protein Ontology||PR:000017387||WD repeat-containing protein 1|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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