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Wdr1
Gene Detail
 Symbol
Name
ID
Wdr1
WD repeat domain 1
MGI:1337100
STS D5Mit77
Synonyms Aip1, D5Wsu185e, rede
Feature Type protein coding gene
Genetic Map
Chromosome 5
20.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:38526813-38561595 bp, - strand
From NCBI annotation of GRCm38

  34783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Wdr1

Human
homologs
Human Homolog WDR1, WD repeat domain 1
NCBI Gene ID 9948
neXtProt AC  NX_O75083
Human Synonyms  AIP1, HEL-S-52, NORI-1
Human Chr (Location)  4p16.1; chr4:10074339-10116949 (-)  GRCh38
Alleles
and
phenotypes
All alleles(21) : Chemically induced (ENU)(1) Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Severe loss of function at this locus causes embryonic lethality. Mice homozygous for a hypomorphic ENU-induced allele exhibit thrombocytopenia due to impaired megakaryocyte maturation and platelet shedding, and develop autoinflammatory disease associated with defects in neutrophil function.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process regulation of oligodendrocyte differentiation, sensory perception of sound
Component actin cytoskeleton, actin filament, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (5)   
Theiler Stages: 11, 22
Assay TypeResults
RNA in situ 3
RT-PCR 6
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000005103 (Evidence)
Entrez Gene22388 (Evidence)
DFCITC1573818, TC1734417, TC1780571
DoTSDT.536506, DT.91426204, DT.97384197, DT.97384198, DT.99871785
NIA Mouse Gene IndexU026139
Consensus CDS ProjectCCDS51485.1
International Mouse Knockout Project StatusWdr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22388 NCBI Gene Model | MGI Sequence Detail 34783 C57BL/6J ±  kb
transcript NM_011715 RefSeq | MGI Sequence Detail 2878 C57BL/6 
polypeptide O88342 UniProt | EBI | MGI Sequence Detail 606 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(4) UniProt(8)
Polymorphisms SNPs within 2kb(207 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR011045 Nitrous oxide reductase, N-terminal
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000017387 WD repeat-containing protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)
Other
accession IDs
MGD-MRK-36476, MGI:107897, MGI:2671645

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory