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Rnf7
Gene Detail
Symbol

Name
ID
Rnf7
ring finger protein 7
MGI:1337096
Synonyms
Rbx2, Sag
Feature Type
protein coding gene
Genetic Map
Chromosome 9
50.63 cM, cytoband D2.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:96470937-96478675 bp, - strand
From VEGA annotation of GRCm38

  7739 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84476  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RNF7
Protein SuperFamily: RING-box protein/anaphase-promoting complex, subunit 11
Gene Tree: Rnf7

Human
homologs
RNF7, ring finger protein 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9616
neXtProt AC: NX_Q9UBF6

Human Synonyms: CKBBP1, ROC2, SAG

Human Chr (Location): 3q22-q24; chr3:141738209-141746803 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(24) Targeted(5)
 
Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with defects in angiogenesis, widespread apoptosis, impaired cell cycle progression of neuronal precursors and embryonic growth retardation.
 
Interactions
Rnf7 interacts with 112 markers (Mir1b, Mir7-1, Mir9-1, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (45)    Tissues (45)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rnf7    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(12) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022972 (Evidence)
Ensembl Gene Model ENSMUSG00000051234 (Evidence)
Entrez Gene 19823 (Evidence)
DFCI TC1678450, TC1572296
DoTS DT.536311, DT.101380218
NIA Mouse Gene Index U031211
Consensus CDS Project CCDS40730.1
International Mouse Phenotyping Consortium Status Rnf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022972 VEGA Gene Model | MGI Sequence Detail 7739 C57BL/6J ±  kb
transcript OTTMUST00000055285 VEGA | MGI Sequence Detail 1232 Not Applicable 
polypeptide OTTMUSP00000026453 VEGA | MGI Sequence Detail 113 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(5) UniProt(2)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR024766 Zinc finger, RING-H2-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000000044 RING-box protein 2
References
(Earliest) J:53898 Duan H, et al., SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol. 1999 Apr;19(4):3145-55
(Latest) J:216274 Tan M, et al., Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. Oncogene. 2014 Oct 30;33(44):5211-20
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory