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Rnf7
Gene Detail
 Symbol
Name
ID
Rnf7
ring finger protein 7
MGI:1337096
Synonyms Rbx2, Sag
Feature Type protein coding gene
Genetic Map
Chromosome 9
50.63 cM, cytoband D2.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:96470941-96478675 bp, - strand
From VEGA annotation of GRCm38

  7735 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84476  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: RING-box protein/anaphase-promoting complex, subunit 11
Gene Tree: Rnf7

Human
homologs
Human Homolog RNF7, ring finger protein 7
NCBI Gene ID 9616
neXtProt AC  NX_Q9UBF6
Human Synonyms  CKBBP1, ROC2, SAG
Human Chr (Location)  3q22-q24; chr3:141738209-141746803 (+)  GRCh38
Alleles
and
phenotypes
All alleles(29) : Gene trapped(24) Targeted(5)
 
Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with defects in angiogenesis, widespread apoptosis, impaired cell cycle progression of neuronal precursors and embryonic growth retardation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic mitochondrial changes, ...
Component Cul5-RING ubiquitin ligase complex, cytoplasm, ...
Function metal ion binding, NEDD8 ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (45)    Images (5)
Theiler Stages: 17, 18, 21, 23, 28
Assay TypeResults
RNA in situ 45
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(12) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022972 (Evidence)
Ensembl Gene ModelENSMUSG00000051234 (Evidence)
Entrez Gene19823 (Evidence)
DFCITC1572296, TC1678450
DoTSDT.101380218, DT.536311
NIA Mouse Gene IndexU031211
Consensus CDS ProjectCCDS40730.1
International Mouse Knockout Project StatusRnf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022972 VEGA Gene Model | MGI Sequence Detail 7735 C57BL/6J ±  kb
transcript OTTMUST00000055285 VEGA | MGI Sequence Detail 1228 Not Applicable 
polypeptide OTTMUSP00000026453 VEGA | MGI Sequence Detail 113 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR024766 Zinc finger, RING-H2-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000000044 RING-box protein 2
References (Earliest) J:53898 Duan H, et al., SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol. 1999 Apr;19(4):3145-55
(Latest) J:207982 Li H, et al., Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. J Clin Invest. 2014 Feb 3;124(2):835-46
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory