About   Help   FAQ
Rnf7 Gene Detail
Summary
  • Symbol
    Rnf7
  • Name
    ring finger protein 7
  • Synonyms
    Rbx2, Sag
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337096
    NCBI Gene: 19823
  • Gene Overview
    MyGene.info: RNF7
Location & Maps
more
  • Sequence Map
    Chr9:96470937-96478675 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7739 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 50.63 cM, cytoband D2.3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF7, ring finger protein 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNF7, ring finger protein 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CKBBP1, ROC2, SAG
  • Links
    NCBI Gene ID: 9616
    neXtProt AC: NX_Q9UBF6

  • Chr Location
    3q22-q24; chr3:141738209-141746803 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    5
  • Genomic Mutations
    1 involving Rnf7
Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with defects in angiogenesis, widespread apoptosis, impaired cell cycle progression of neuronal precursors and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022972 VEGA Gene Model | MGI Sequence Detail 7739 C57BL/6J ±  kb
transcript OTTMUST00000055285 VEGA | MGI Sequence Detail 1232 Not Applicable  
polypeptide OTTMUSP00000026453 VEGA | MGI Sequence Detail 113 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    122 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR024991 Anaphase-promoting complex subunit 11
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR024766 Zinc finger, RING-H2-type
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
less
  • All nucleic 15
    Genomic 1
    cDNA 13
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:53898 Duan H, et al., SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol. 1999 Apr;19(4):3145-55
  • Latest
    J:227321 Xie CM, et al., Erbin is a novel substrate of the Sag-betaTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015 Jun 8;209(5):721-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory