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Ncor2
Gene Detail
Symbol

Name
ID
Ncor2
nuclear receptor co-repressor 2
MGI:1337080
Synonyms
SMRT, SMRTe
Feature Type
protein coding gene
Genetic Map
Chromosome 5
63.96 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:125017153-125179219 bp, - strand
From VEGA annotation of GRCm38

  162067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31370  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NCOR2
Gene Tree: Ncor2

Human
homologs
NCOR2, nuclear receptor corepressor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9612
neXtProt AC: NX_Q9Y618

Human Synonyms: CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC1, TRAC-1

Human Chr (Location): 12q24; chr12:124324411-124567464 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(146) : Gene trapped(143) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects.
 
Human Diseases Modeled in Mice Using Ncor2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(8)
Interactions
Ncor2 interacts with 192 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process cell proliferation in forebrain, forebrain development, ...
Component chromatin, histone deacetylase complex, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (119)    Tissues (51)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
RT-PCR 7
cDNA source data(108)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ncor2 ; ZFIN ncor2    NEW 
Molecular
reagents
All nucleic(112) cDNA(109) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017150 (Evidence)
Ensembl Gene Model ENSMUSG00000029478 (Evidence)
Entrez Gene 20602 (Evidence)
UniGene 278646
DFCI TC1577916, TC1588958, TC1613581, TC1654157
DoTS DT.101352097, DT.101387169, DT.101387170, DT.494902, DT.55241304, DT.99841912
NIA Mouse Gene Index U026740
Consensus CDS Project CCDS39285.2, CCDS57381.1, CCDS57382.1
International Mouse Phenotyping Consortium Status Ncor2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017150 VEGA Gene Model | MGI Sequence Detail 162067 C57BL/6J ±  kb
transcript OTTMUST00000041507 VEGA | MGI Sequence Detail 7780 Not Applicable 
polypeptide OTTMUSP00000018646 VEGA | MGI Sequence Detail 2473 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(47) UniProt(15)
Polymorphisms
SNPs within 2kb(779 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR017884 SANT domain
InterPro IPR001005 SANT/Myb domain
Protein Ontology PR:000011048 nuclear receptor corepressor 2
References
(Earliest) J:53498 Ordentlich P, et al., Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2639-44
(Latest) J:222085 Hellsten KS, et al., Paradoxical widespread c-Fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABA(A) alpha6 subunit. Neuroscience. 2015 May 7;293:123-35
All references(72)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory