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Ncor2 Gene Detail
Summary
  • Symbol
    Ncor2
  • Name
    nuclear receptor co-repressor 2
  • Synonyms
    SMRT, SMRTe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337080
    NCBI Gene: 20602
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:125017153-125179219 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      162067 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.96 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NCOR2, nuclear receptor corepressor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCOR2, nuclear receptor corepressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC1, TRAC-1
  • Links
    NCBI Gene ID: 9612
    neXtProt AC: NX_Q9Y618
    UniProt: Q9Y618

  • Chr Location
    12q24.31; chr12:124324411-124567464 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31370
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NCOR2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ncor2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 5 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017150 VEGA Gene Model | MGI Sequence Detail 162067 C57BL/6J ±  kb
    transcript OTTMUST00000041507 VEGA | MGI Sequence Detail 7780 Not Applicable  
    polypeptide OTTMUSP00000018646 VEGA | MGI Sequence Detail 2473 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      775 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 110
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 22
      Phenotypes 31
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:247701 Poleshko A, et al., Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. 2017 Oct 19;171(3):573-587.e14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory