Ncor2
Gene Detail

Symbol Name ID

Ncor2 nuclear receptor co-repressor 2 MGI:1337080

Synonyms

SMRT, SMRTe

Feature Type

protein coding gene

Genetic Map

Chromosome 5

63.96 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:125017153-125179219 bp, - strand From VEGA annotation of GRCm38   162067 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31370  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ncor2

Human homologs

Human Homolog		NCOR2, nuclear receptor corepressor 2
NCBI Gene ID		9612
neXtProt AC		NX_Q9Y618
Human Synonyms		CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC1, TRAC-1
Human Chr (Location)		12q24; chr12:124808957-125052010 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(145) : Targeted(2) Gene trapped(143)
 

Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	cell proliferation in forebrain, forebrain development, ...
Component	chromatin, histone deacetylase complex, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (119)    Tissues (49)    Images (23)
Theiler Stages: 15, 17, 19, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	112
RT-PCR	7

cDNA source data(108)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(112) cDNA(109) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017150 (Evidence)
Ensembl Gene Model	ENSMUSG00000029478 (Evidence)
Entrez Gene	20602 (Evidence)
UniGene	278646
DFCI	TC1577916, TC1588958, TC1613581, TC1654157
DoTS	DT.101352097, DT.101387169, DT.101387170, DT.494902, DT.55241304, DT.99841912
NIA Mouse Gene Index	U026740
Consensus CDS Project	CCDS39285.2, CCDS57381.1, CCDS57382.1
International Mouse Knockout Project Status	Ncor2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017150	VEGA Gene Model | MGI Sequence Detail	162067	C57BL/6J
transcript	OTTMUST00000041507	VEGA | MGI Sequence Detail	7780	Not Applicable
polypeptide	OTTMUSP00000018646	VEGA | MGI Sequence Detail	2473	Not Applicable

All sequences(93) RefSeq(6) UniProt(13)

Polymorphisms

SNPs(669 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009057	Homeodomain-like
InterPro	IPR017884	SANT domain
InterPro	IPR001005	SANT/Myb domain
Protein Ontology	PR:000011048	nuclear receptor corepressor 2

References

(Earliest) J:53498 Ordentlich P, et al., Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2639-44
(Latest) J:178114 Pei L, et al., Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med. 2011;17(11):1466-72
All references(65)