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Ncor2
Gene Detail
 Symbol
Name
ID
Ncor2
nuclear receptor co-repressor 2
MGI:1337080
Synonyms SMRT, SMRTe
Feature Type protein coding gene
Genetic Map
Chromosome 5
63.96 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:125017153-125179219 bp, - strand
From VEGA annotation of GRCm38

  162067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31370  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ncor2

Human
homologs
Human Homolog NCOR2, nuclear receptor corepressor 2
NCBI Gene ID 9612
neXtProt AC  NX_Q9Y618
Human Synonyms  CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC1, TRAC-1
Human Chr (Location)  12q24; chr12:124324411-124567464 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(146) : Gene trapped(143) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects.
 
Human Diseases Modeled Using Mouse Ncor2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Ncor2 interacts with 193 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process cell proliferation in forebrain, forebrain development, ...
Component chromatin, histone deacetylase complex, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (119)    Tissues (49)    Images (23)
Theiler Stages: 15, 17, 19, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 112
RT-PCR 7
cDNA source data(108)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(109) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017150 (Evidence)
Ensembl Gene ModelENSMUSG00000029478 (Evidence)
Entrez Gene20602 (Evidence)
UniGene278646
DFCITC1577916, TC1588958, TC1613581, TC1654157
DoTSDT.101352097, DT.101387169, DT.101387170, DT.494902, DT.55241304, DT.99841912
NIA Mouse Gene IndexU026740
Consensus CDS ProjectCCDS39285.2, CCDS57381.1, CCDS57382.1
International Mouse Knockout Project StatusNcor2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017150 VEGA Gene Model | MGI Sequence Detail 162067 C57BL/6J ±  kb
transcript OTTMUST00000041507 VEGA | MGI Sequence Detail 7780 Not Applicable 
polypeptide OTTMUSP00000018646 VEGA | MGI Sequence Detail 2473 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(14) UniProt(13)
Polymorphisms SNPs within 2kb(779 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR017884 SANT domain
InterPro IPR001005 SANT/Myb domain
Protein Ontology PR:000011048 nuclear receptor corepressor 2
References (Earliest) J:53498 Ordentlich P, et al., Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2639-44
(Latest) J:206152 Sun Z, et al., Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 2013 Dec 26;52(6):769-82
All references(68)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory