About   Help   FAQ
Ap4s1
Gene Detail
Symbol

Name
ID
Ap4s1
adaptor-related protein complex AP-4, sigma 1
MGI:1337065
Feature Type
protein coding gene
Genetic Map
Chromosome 12
22.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:51690966-51738939 bp, + strand
From NCBI annotation of GRCm38

  47974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap4s1

Human
homologs
Human Homolog AP4S1, adaptor-related protein complex 4, sigma 1 subunit
NCBI Gene ID 11154
neXtProt AC  NX_Q9Y587
Human Synonyms  AP47B, CLA20, CLAPS4, CPSQ6, SPG52
Human Chr (Location)  14q12; chr14:31025106-31096450 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AP4S1
Mutations,
alleles, and
phenotypes
All mutations/alleles(150) : Gene trapped(149) Targeted(1)
Interactions
Ap4s1 interacts with 41 markers (Mir17, Mir20b, Mir100, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process intracellular protein transport, protein transport, ...
Component coated pit, Golgi apparatus, ...
Function protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000020955 (Evidence)
Entrez Gene11782 (Evidence)
UniGene386749
DFCITC1580573, TC1594430, TC1773290
DoTSDT.50316696, DT.531248, DT.94335378
NIA Mouse Gene IndexU013932
Consensus CDS ProjectCCDS36441.1
International Mouse Knockout Project StatusAp4s1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11782 NCBI Gene Model | MGI Sequence Detail 47974 C57BL/6J ±  kb
transcript NM_021710 RefSeq | MGI Sequence Detail 1113 C57BL/6 
polypeptide Q9WVL1 UniProt | EBI | MGI Sequence Detail 144 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(608 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016635 Adaptor protein complex, sigma subunit
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004114 AP-4 complex subunit sigma-1
Graphical View of Protein Domain Structure
References
(Earliest) J:48443 Odorizzi G, et al., The AP-3 complex: a coat of many colours. Trends Cell Biol. 1998 Jul;8(7):282-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGI:2144780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory