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Ap4s1
Gene Detail
Symbol

Name
ID
Ap4s1
adaptor-related protein complex AP-4, sigma 1
MGI:1337065
Feature Type
protein coding gene
Genetic Map
Chromosome 12
22.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:51690966-51738939 bp, + strand
From Ensembl annotation of GRCm38

  47974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AP4S1
Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap4s1

Human
homologs
AP4S1, adaptor-related protein complex 4, sigma 1 subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11154
neXtProt AC: NX_Q9Y587

Human Synonyms: AP47B, CLA20, CLAPS4, CPSQ6, SPG52

Human Chr (Location): 14q12; chr14:31025106-31096450 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AP4S1

Mutations,
alleles, and
phenotypes
All mutations/alleles(150) : Gene trapped(149) Targeted(1)
Interactions
Ap4s1 interacts with 41 markers (Mir17, Mir20b, Mir100, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process intracellular protein transport, protein transport, ...
Component coated pit, Golgi apparatus, ...
Function protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap4s1    NEW 
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020955 (Evidence)
Entrez Gene 11782 (Evidence)
UniGene 386749
DFCI TC1580573, TC1594430, TC1773290
DoTS DT.50316696, DT.531248, DT.94335378
NIA Mouse Gene Index U013932
Consensus CDS Project CCDS36441.1
International Mouse Phenotyping Consortium Status Ap4s1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020955 Ensembl Gene Model | MGI Sequence Detail 47974 C57BL/6J ±  kb
transcript ENSMUST00000021338 Ensembl | MGI Sequence Detail 1113 Not Applicable 
polypeptide ENSMUSP00000021338 Ensembl | MGI Sequence Detail 144 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(608 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016635 Adaptor protein complex, sigma subunit
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004114 AP-4 complex subunit sigma-1
References
(Earliest) J:48443 Odorizzi G, et al., The AP-3 complex: a coat of many colours. Trends Cell Biol. 1998 Jul;8(7):282-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2144780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory