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Ncr1 Gene Detail
Summary
  • Symbol
    Ncr1
  • Name
    natural cytotoxicity triggering receptor 1
  • Synonyms
    Ly94, MAR1 (mouse activating receptor 1), NKp46
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336212
    NCBI Gene: 17086
  • Gene Overview
    MyGene.info: NCR1
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.50 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NCR1, natural cytotoxicity triggering receptor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NCR1, natural cytotoxicity triggering receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD335, LY94, NK-p46, NKP46
  • Links
    NCBI Gene ID: 9437
    neXtProt AC: NX_O76036

  • Chr Location
    19q13.42; chr19:54905992-54938208 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    1 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Targeted
    3
  • Incidental Mutations
Mutations in this gene lead to alterations in susceptibility to viral infection induced morbidity/mortality, NK cell number, NK cell cytolysis, and T cell responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027904 VEGA Gene Model | MGI Sequence Detail 7441 C57BL/6J ±  kb
transcript OTTMUST00000069117 VEGA | MGI Sequence Detail 1463 Not Applicable  
polypeptide OTTMUSP00000035055 VEGA | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    94 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 54
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 33
  • Earliest
    J:53412 Biassoni R, et al., The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur J Immunol. 1999 Mar;29(3):1014-20
  • Latest
    J:232648 Madera S, et al., Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. J Exp Med. 2016 Feb 8;213(2):225-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory