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Ncr1
Gene Detail
 Symbol
Name
ID
Ncr1
natural cytotoxicity triggering receptor 1
MGI:1336212
Synonyms Ly94, MAR1 (mouse activating receptor 1), NKp46
Feature Type protein coding gene
Genetic Map
Chromosome 7
2.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:4337724-4345164 bp, + strand
From VEGA annotation of GRCm38

  7441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ncr1

Human
homologs
Human Homolog NCR1, natural cytotoxicity triggering receptor 1
NCBI Gene ID 9437
neXtProt AC  NX_O76036
Human Synonyms  CD335, LY94, NK-p46, NKP46
Human Chr (Location)  19q13.42; chr19:54906150-54913071 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene lead to alterations in susceptibility to viral infection induced morbidity/mortality, NK cell number, NK cell cytolysis, and T cell responses.
 
Phenotype Images(1)
Interactions
Ncr1 interacts with 87 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027904 (Evidence)
Ensembl Gene ModelENSMUSG00000062524 (Evidence)
Entrez Gene17086 (Evidence)
UniGene240231
DFCITC1586822
DoTSDT.101342509, DT.40147607
NIA Mouse Gene IndexU007613
Consensus CDS ProjectCCDS20734.1
International Mouse Knockout Project StatusNcr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027904 VEGA Gene Model | MGI Sequence Detail 7441 C57BL/6J ±  kb
transcript OTTMUST00000069117 VEGA | MGI Sequence Detail 1463 Not Applicable 
polypeptide OTTMUSP00000035055 VEGA | MGI Sequence Detail 325 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001893 natural cytotoxicity triggering receptor 1
References (Earliest) J:53412 Biassoni R, et al., The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur J Immunol. 1999 Mar;29(3):1014-20
(Latest) J:211785 Ghadially H, et al., NK Cell Receptor NKp46 Regulates Graft-versus-Host Disease. Cell Rep. 2014 Jun 26;7(6):1809-14
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory