Ncr1 MGI Mouse Gene Detail - MGI:1336212 - natural cytotoxicity triggering receptor 1

Symbol

Ncr1
Name

natural cytotoxicity triggering receptor 1
Synonyms

Cd335, Ly94, MAR1 (mouse activating receptor 1), NKp46

Feature Type

protein coding gene
IDs

MGI:1336212
NCBI Gene: 17086
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:4340723-4348163 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 2.50 cM
Mapping Data

2 experiments

SNPs within 2kb

311 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336212	protein coding gene	Chr7:4340714-4348183 (+)
129S1/SvImJ	ENSMUSG00200037280	protein coding gene	Chr7:1080195-1087653 (+)
A/J	ENSMUSG00195050504	protein coding gene	Chr7:1060078-1067532 (+)
AKR/J	ENSMUSG00220025810	protein coding gene	Chr7:3028642-3036097 (-)
BALB/cJ	ENSMUSG00180041258	protein coding gene	Chr7:1026173-1033633 (+)
C3H/HeJ	ENSMUSG00175036840	protein coding gene	Chr7:1018457-1025909 (+)
C57BL/6NJ	ENSMUSG00215039238	protein coding gene	Chr7:1058261-1065700 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029109	protein coding gene	Chr7:1033419-1040548 (+)
CAST/EiJ	ENSTCUG00005026259	protein coding gene	Chr7:1238346-1245547 (+)
CBA/J	ENSMUSG00210046122	protein coding gene	Chr7:1018460-1025918 (+)
DBA/2J	ENSMUSG00185037787	protein coding gene	Chr7:1203922-1211378 (+)
FVB/NJ	ENSMUSG00205035967	protein coding gene	Chr7:1007330-1014788 (+)
JF1/MsJ	ENSUMUG00000019194	protein coding gene	Chr7:1279383-1287055 (+)
LP/J	ENSMUSG00230034078	protein coding gene	Chr7:4225715-4233171 (+)
NOD/ShiLtJ	ENSMUSG00190044273	protein coding gene	Chr7:1090378-1097832 (+)
NZO/HlLtJ	ENSMUSG00225016018	protein coding gene	Chr7:2138458-2145916 (+)
PWK/PhJ	ENSLUMG00010044830	protein coding gene	Chr7:4767144-4774624 (+)
SPRET/EiJ	ENSMSPG00010039854	protein coding gene	Chr7:1217338-1224402 (+)
WSB/EiJ	ENSIUOG00005050461	protein coding gene	Chr7:1030537-1039916 (+)

Human Ortholog

NCR1, natural cytotoxicity triggering receptor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCR1, natural cytotoxicity triggering receptor 1
Synonyms

CD335, LY94, NK-p46, NKP46
Links

HGNC:6731

NCBI Gene ID: 9437

UniProt: O76036
Chr Location

19q13.42; chr19:54898198-54938208 (+) GRCh38

MGI Vertebrate Homology

Ncr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NCR1
Gene Tree

Ncr1

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Phenotype Summary

15 phenotypes from 4 alleles in 3 genetic backgrounds
12 phenotypes from multigenic genotypes
1 images
238 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (ENU)

1
Endonuclease-mediated

22
Spontaneous

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mutations in this gene lead to alterations in susceptibility to viral infection induced morbidity/mortality, NK cell number, NK cell cytolysis, and T cell responses.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

4
UniProt

4
CCDS

CCDS20734.1

Ensembl

ENSMUSG00000062524 (Evidence)
NCBI Gene

17086

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062524	Ensembl Gene Model \| MGI Sequence Detail	7441	C57BL/6J	± kb
transcript	ENSMUST00000006792	Ensembl \| MGI Sequence Detail	1463	Not Applicable
polypeptide	ENSMUSP00000006792	Ensembl \| MGI Sequence Detail	325	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001893 natural cytotoxicity triggering receptor 1

(term hierarchy)
InterPro Domains

IPR003599 Immunoglobulin domain subtype

IPR013151 Immunoglobulin-like beta-sandwich domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR050412 Immunoglobulin-like Receptors in Immune Regulation
GlyGen

Q8C567 3 sites

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 3

Summaries

All 302

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 238
Earliest

J:53412 Biassoni R, et al., The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur J Immunol. 1999 Mar;29(3):1014-20
Latest

J:391284 Neo SY, et al., Nur77 agonism invigorates Natural Killer cell immunity against hepatocellular carcinoma. Nat Commun. 2026 Jun 30;17(1)

TSS for Ncr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64326	Chr7:4340709-4340735 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24