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Ncr1
Gene Detail
Symbol

Name
ID
Ncr1
natural cytotoxicity triggering receptor 1
MGI:1336212
Synonyms
Ly94, MAR1 (mouse activating receptor 1), NKp46
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:4337724-4345164 bp, + strand
From VEGA annotation of GRCm38

  7441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: NCR1
Gene Tree: Ncr1

Human
homologs
NCR1, natural cytotoxicity triggering receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9437
neXtProt AC: NX_O76036

Human Synonyms: CD335, LY94, NK-p46, NKP46

Human Chr (Location): 19q13.42; chr19:54905992-54938208 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene lead to alterations in susceptibility to viral infection induced morbidity/mortality, NK cell number, NK cell cytolysis, and T cell responses.
 
Phenotype Images(1)
Interactions
Ncr1 interacts with 87 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process defense response to virus, detection of virus
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027904 (Evidence)
Ensembl Gene Model ENSMUSG00000062524 (Evidence)
Entrez Gene 17086 (Evidence)
UniGene 240231
DFCI TC1586822
DoTS DT.101342509, DT.40147607
NIA Mouse Gene Index U007613
Consensus CDS Project CCDS20734.1
International Mouse Phenotyping Consortium Status Ncr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027904 VEGA Gene Model | MGI Sequence Detail 7441 C57BL/6J ±  kb
transcript OTTMUST00000069117 VEGA | MGI Sequence Detail 1463 Not Applicable 
polypeptide OTTMUSP00000035055 VEGA | MGI Sequence Detail 325 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001893 natural cytotoxicity triggering receptor 1
References
(Earliest) J:53412 Biassoni R, et al., The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur J Immunol. 1999 Mar;29(3):1014-20
(Latest) J:218321 Geiger TL, et al., Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. J Exp Med. 2014 Aug 25;211(9):1723-31
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory