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Tsix Gene Detail
Summary
  • Symbol
    Tsix
  • Name
    X (inactive)-specific transcript, opposite strand
  • Feature Type
    antisense lncRNA gene
  • IDs
    MGI:1336196
    NCBI Gene: 22097
  • Gene Overview
    MyGene.info: TSIX
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:103431517-103484957 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 46.13 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336196
antisense lncRNA gene ChrX:103431517-103484957 (.)
129S1/SvImJ MGP_129S1SvImJ_G0004743
antisense lncRNA gene ChrX:100075527-100130888 (+)
A/J MGP_AJ_G0004721
antisense lncRNA gene ChrX:100013228-100064718 (+)
AKR/J MGP_AKRJ_G0004704
antisense lncRNA gene ChrX:103024648-103085294 (+)
BALB/cJ MGP_BALBcJ_G0004705
antisense lncRNA gene ChrX:98810779-98862687 (+)
C3H/HeJ MGP_C3HHeJ_G0004653
antisense lncRNA gene ChrX:100538684-100593905 (+)
C57BL/6NJ MGP_C57BL6NJ_G0004855
antisense lncRNA gene ChrX:103043968-103096471 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0004291
antisense lncRNA gene ChrX:97655913-97706496 (+)
CAST/EiJ MGP_CASTEiJ_G0004610
antisense lncRNA gene ChrX:84813518-84869396 (+)
CBA/J MGP_CBAJ_G0004647
antisense lncRNA gene ChrX:106221991-106282286 (+)
DBA/2J MGP_DBA2J_G0004663
antisense lncRNA gene ChrX:99256544-99309840 (+)
FVB/NJ MGP_FVBNJ_G0004681
antisense lncRNA gene ChrX:98559438-98613886 (+)
LP/J MGP_LPJ_G0004744
antisense lncRNA gene ChrX:101092321-101150826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0004667
antisense lncRNA gene ChrX:110879655-110937532 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0004855
antisense lncRNA gene ChrX:99763347-99819939 (+)
PWK/PhJ MGP_PWKPhJ_G0004561
antisense lncRNA gene ChrX:82393056-82447144 (+)
SPRET/EiJ MGP_SPRETEiJ_G0004495
antisense lncRNA gene ChrX:85511144-85569717 (+)
WSB/EiJ MGP_WSBEiJ_G0004653
antisense lncRNA gene ChrX:98488121-98543615 (+)



Homology
more
  • Human Ortholog
    TSIX, TSIX transcript, XIST antisense RNA
  • Human Ortholog
    TSIX, TSIX transcript, XIST antisense RNA
    Orthology source: HGNC
  • Synonyms
    LINC00013, NCRNA00013, XISTAS, XIST-AS, XIST-AS1
  • Links
    NCBI Gene ID: 9383

  • Chr Location
    Xq13.2; chrX:73792205-73829231 (+)  GRCh38.p7

  • HCOP
    human homology predictions: TSIX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 5 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Maternal transmission of a null allele in this imprinted gene prevents Xist accumulation disrupting X-inactivation and causing early embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22097 NCBI Gene Model | MGI Sequence Detail 53441 C57BL/6J ±  kb
    transcript NR_002844 RefSeq | MGI Sequence Detail 4306 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 3
      Primer pair 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 10
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:10451 Fingeroth JD, Comparative structure and evolution of murine CR2. The homolog of the human C3d/EBV receptor (CD21). J Immunol. 1990 May 1;144(9):3458-67
    • Latest
      J:264367 Carrette LLG, et al., Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8185-8190

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory