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Prkaa2
Gene Detail
 Symbol
Name
ID
Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
MGI:1336173
Synonyms 2310008I11Rik, AMPKalpha2
Feature Type protein coding gene
Genetic Map
Chromosome 4
49.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:105029874-105109890 bp, - strand
From VEGA annotation of GRCm38

  80017 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Snf1/AMPK-type protein kinase, catalytic subunit
Gene Tree: Prkaa2

Human
homologs
Human Homolog PRKAA2, protein kinase, AMP-activated, alpha 2 catalytic subunit
NCBI Gene ID 5563
neXtProt AC  NX_P54646
Human Synonyms  AMPK, AMPK2, AMPKa2, PRKAA
Human Chr (Location)  1p31; chr1:56645317-56715335 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are hyperglycemic, hypoinsulinemic, and show glucose intolerance and insulin resistance.
 
Interactions
Prkaa2 interacts with 498 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process autophagy, cellular response to glucose starvation, ...
Component AMP-activated protein kinase complex, apical plasma membrane, ...
Function [acetyl-CoA carboxylase] kinase activity, AMP-activated protein kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (59)    Tissues (4)    Images (22)
Theiler Stages: 20, 23
Assay TypeResults
RNA in situ 33
Western blot 26
cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008125 (Evidence)
Ensembl Gene ModelENSMUSG00000028518 (Evidence)
Entrez Gene108079 (Evidence)
UniGene48638
DFCITC1601579, TC1623476, TC1672921
DoTSDT.60101484
NIA Mouse Gene IndexU025319, U181165
EC2.7.11.1, 2.7.11.27, 2.7.11.31
Consensus CDS ProjectCCDS18416.1
International Mouse Knockout Project StatusPrkaa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008125 VEGA Gene Model | MGI Sequence Detail 80017 C57BL/6J ±  kb
transcript OTTMUST00000018469 VEGA | MGI Sequence Detail 7969 Not Applicable 
polypeptide OTTMUSP00000008485 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(524 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013219 5'-AMP-activated protein kinase catalytic subunit alpha-2
References (Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:209505 Hasenour CM, et al., 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo. J Biol Chem. 2014 Feb 28;289(9):5950-9
All references(146)
Other
accession IDs
MGI:1913766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory