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Prkaa2
Gene Detail
Symbol

Name
ID
Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
MGI:1336173
Synonyms
2310008I11Rik, AMPKalpha2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
49.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:105029874-105109890 bp, - strand
From VEGA annotation of GRCm38

  80017 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKAA2
Protein SuperFamily: Snf1/AMPK-type protein kinase, catalytic subunit
Gene Tree: Prkaa2

Human
homologs
PRKAA2, protein kinase, AMP-activated, alpha 2 catalytic subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5563
neXtProt AC: NX_P54646

Human Synonyms: AMPK, AMPK2, AMPKa2, PRKAA

Human Chr (Location): 1p31; chr1:56645317-56715335 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Prkaa2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice are hyperglycemic, hypoinsulinemic, and show glucose intolerance and insulin resistance.
 
Interactions
Prkaa2 interacts with 498 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (59)    Tissues (4)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
Western blot 26
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkaa2    NEW 
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000008125 (Evidence)
Ensembl Gene Model ENSMUSG00000028518 (Evidence)
Entrez Gene 108079 (Evidence)
UniGene 48638
DFCI TC1623476, TC1601579, TC1672921
DoTS DT.60101484
NIA Mouse Gene Index U025319, U181165
EC 2.7.11.1, 2.7.11.27, 2.7.11.31
Consensus CDS Project CCDS18416.1
International Mouse Phenotyping Consortium Status Prkaa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008125 VEGA Gene Model | MGI Sequence Detail 80017 C57BL/6J ±  kb
transcript OTTMUST00000018469 VEGA | MGI Sequence Detail 7969 Not Applicable 
polypeptide OTTMUSP00000008485 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(524 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013219 5'-AMP-activated protein kinase catalytic subunit alpha-2
References
(Earliest) J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
(Latest) J:220329 Chen T, et al., Muscle-selective knockout of AMPKalpha2 does not exacerbate diet-induced obesity probably related to altered myokines expression. Biochem Biophys Res Commun. 2015 Mar 13;458(3):449-55
All references(159)
Other
accession IDs
MGI:1913766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory