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Prkaa2 Gene Detail
Summary
  • Symbol
    Prkaa2
  • Name
    protein kinase, AMP-activated, alpha 2 catalytic subunit
  • Synonyms
    2310008I11Rik, AMPKalpha2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336173
    NCBI Gene: 108079
  • Gene Overview
    MyGene.info: PRKAA2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:105029874-105109890 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80017 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 49.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PRKAA2, protein kinase AMP-activated catalytic subunit alpha 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKAA2, protein kinase AMP-activated catalytic subunit alpha 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMPK, AMPK2, AMPKa2, PRKAA
  • Links
    NCBI Gene ID: 5563
    neXtProt AC: NX_P54646
    UniProt: P54646

  • Chr Location
    1p32.2; chr1:56645317-56715335 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    196 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are hyperglycemic, hypoinsulinemic, and show glucose intolerance and insulin resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008125 VEGA Gene Model | MGI Sequence Detail 80017 C57BL/6J ±  kb
    transcript OTTMUST00000018469 VEGA | MGI Sequence Detail 7969 Not Applicable  
    polypeptide OTTMUSP00000008485 VEGA | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      524 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 59

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1913766
    References
    more
    • Summaries
      All 288
      Developmental Gene Expression 17
      Gene Ontology 21
      Phenotypes 196
    • Earliest
      J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
    • Latest
      J:261386 Brynildsen JK, et al., Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4282-4287

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory