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Cflar Gene Detail
Summary
  • Symbol
    Cflar
  • Name
    CASP8 and FADD-like apoptosis regulator
  • Synonyms
    2310024N18Rik, A430105C05Rik, Cash, Casper, c-Flip, Flip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336166
    NCBI Gene: 12633
Location & Maps
more
  • Sequence Map
    Chr1:58711508-58758884 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47377 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CFLAR, CASP8 and FADD like apoptosis regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CFLAR, CASP8 and FADD like apoptosis regulator
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CASH, CASP8AP1, Casper, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CLARP, FLAME, FLAME1, FLAME-1, FLIP, I-FLICE, MRIT
  • Links
    NCBI Gene ID: 8837
    neXtProt AC: NX_O15519

  • Chr Location
    2q33-q34; chr2:201116154-201172688 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Cflar
  • Incidental Mutations
    APF
Homozygous mutation of this gene results in embryonic lethality by E10.5. Mutant embryos exhibit cardiac developmental abnormalities and pooling of blood in the head and abdominal regions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019581 VEGA Gene Model | MGI Sequence Detail 47377 C57BL/6J ±  kb
transcript OTTMUST00000046765 VEGA | MGI Sequence Detail 1771 Not Applicable  
polypeptide OTTMUSP00000021141 VEGA | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    270 from dbSNP Build 137
Protein
Information
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  • Protein Ontology
    PR:000002282 CASP8 and FADD-like apoptosis regulator
Molecular
Reagents
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  • All nucleic 20
    Genomic 1
    cDNA 19

    Microarray probesets 10
Other
Accession IDs
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MGI:1096876, MGI:1916820, MGI:1925024, MGI:2138307, MGI:2138466
References
more
  • Summaries
    All 69
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:41473 Irmler M, et al., Inhibition of death receptor signals by cellular FLIP [see comments]. Nature. 1997 Jul 10;388(6638):190-5
  • Latest
    J:224881 Huang QQ, et al., CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis. Nat Commun. 2015;6:7086

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory