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Cflar
Gene Detail
Symbol

Name
ID
Cflar
CASP8 and FADD-like apoptosis regulator
MGI:1336166
Synonyms
2310024N18Rik, A430105C05Rik, Cash, Casper, c-Flip, Flip
Feature Type
protein coding gene
Genetic Map
Chromosome 1
29.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:58711508-58758884 bp, + strand
From VEGA annotation of GRCm38

  47377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7652  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Casp8 and Fadd-like apoptosis regulator/caspase, types 8/10
Gene Tree: Cflar

Human
homologs
Human Homolog CFLAR, CASP8 and FADD-like apoptosis regulator
NCBI Gene ID 8837
neXtProt AC  NX_O15519
Human Synonyms  CASH, CASP8AP1, Casper, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CLARP, FLAME, FLAME1, FLAME-1, FLIP, I-FLICE, MRIT
Human Chr (Location)  2q33-q34; chr2:201116154-201172688 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in embryonic lethality by E10.5. Mutant embryos exhibit cardiac developmental abnormalities and pooling of blood in the head and abdominal regions.
 
Interactions
Cflar interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (242)    Tissues (55)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 240
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(10)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019581 VEGA Gene Model | MGI Sequence Detail 47377 C57BL/6J ±  kb
transcript OTTMUST00000046765 VEGA | MGI Sequence Detail 1771 Not Applicable 
polypeptide OTTMUSP00000021141 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(12)
Polymorphisms
SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000002282 CASP8 and FADD-like apoptosis regulator
References
(Earliest) J:41473 Irmler M, et al., Inhibition of death receptor signals by cellular FLIP [see comments]. Nature. 1997 Jul 10;388(6638):190-5
(Latest) J:205617 He MX, et al., A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. Cell Death Differ. 2013 Feb;20(2):188-97
All references(69)
Other
accession IDs
MGI:1096876, MGI:1916820, MGI:1925024, MGI:2138307, MGI:2138466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory