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Cflar
Gene Detail
 Symbol
Name
ID
Cflar
CASP8 and FADD-like apoptosis regulator
MGI:1336166
Synonyms 2310024N18Rik, A430105C05Rik, Cash, Casper, c-Flip, Flip
Feature Type protein coding gene
Genetic Map
Chromosome 1
29.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:58711508-58758884 bp, + strand
From VEGA annotation of GRCm38

  47377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7652  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Casp8 and Fadd-like apoptosis regulator/caspase, types 8/10
Gene Tree: Cflar

Human
homologs
Human Homolog CFLAR, CASP8 and FADD-like apoptosis regulator
NCBI Gene ID 8837
neXtProt AC  NX_O15519
Human Synonyms  CASH, CASP8AP1, Casper, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CLARP, FLAME, FLAME1, FLAME-1, FLIP, I-FLICE, MRIT
Human Chr (Location)  2q33-q34; chr2:201116154-201172688 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in embryonic lethality by E10.5. Mutant embryos exhibit cardiac developmental abnormalities and pooling of blood in the head and abdominal regions.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process apoptotic process, negative regulation of apoptotic process, ...
Component CD95 death-inducing signaling complex, cytoplasm, ...
Function cysteine-type endopeptidase activity, death effector domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (242)    Tissues (55)    Images (37)
Theiler Stages: 15, 17, 19, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 240
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000019581 (Evidence)
Ensembl Gene ModelENSMUSG00000026031 (Evidence)
Entrez Gene12633 (Evidence)
DFCITC1582887, TC1583433, TC1585110, TC1609554, TC1658947, TC1675615, TC1685417, TC1713976
DoTSDT.110701458, DT.110891839, DT.110891840, DT.489474, DT.490505, DT.60103629, DT.91396374, DT.94180301, DT.94180304, DT.97399168, DT.97399169, DT.97410608, DT.99663283
NIA Mouse Gene IndexU000311, U023967
Consensus CDS ProjectCCDS14978.1, CCDS35582.1
International Mouse Knockout Project StatusCflar
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019581 VEGA Gene Model | MGI Sequence Detail 47377 C57BL/6J ±  kb
transcript OTTMUST00000046765 VEGA | MGI Sequence Detail 1771 Not Applicable 
polypeptide OTTMUSP00000021141 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(12)
Polymorphisms SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000002282 CASP8 and FADD-like apoptosis regulator
References (Earliest) J:41473 Irmler M, et al., Inhibition of death receptor signals by cellular FLIP [see comments]. Nature. 1997 Jul 10;388(6638):190-5
(Latest) J:205617 He MX, et al., A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. Cell Death Differ. 2013 Feb;20(2):188-97
All references(69)
Other
accession IDs
MGI:1096876, MGI:1916820, MGI:1925024, MGI:2138307, MGI:2138466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory