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Fem1b
Gene Detail
 Symbol
Name
ID
Fem1b
feminization 1 homolog b (C. elegans)
MGI:1335087
Synonyms mKIAA0396
Feature Type protein coding gene
Genetic Map
Chromosome 9
33.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:62791832-62811648 bp, - strand
From Ensembl annotation of GRCm38

  19817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fem1b

Human
homologs
Human Homolog FEM1B, fem-1 homolog b (C. elegans)
NCBI Gene ID 10116
neXtProt AC  NX_Q9UK73
Human Synonyms  F1AA, F1A-ALPHA, FEM1-beta
Human Chr (Location)  15q22; chr15:68277803-68295865 (+)  GRCh38
Alleles
and
phenotypes
All alleles(19) : Gene trapped(15) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants display abnormal glucose tolerance due to defective glucose-stimulated insulin secretion.
 
Human Diseases Modeled Using Mouse Fem1b (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, branching involved in prostate gland morphogenesis, ...
Component cytoplasm, nucleus
Function death receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (86)    Tissues (80)    Images (15)
Theiler Stages: 10, 18, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 74
Northern blot 12
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000032244 (Evidence)
Entrez Gene14155 (Evidence)
DFCITC1577004, TC1602593, TC1624877, TC1644402, TC1695759
DoTSDT.489799
NIA Mouse Gene IndexU043863
Consensus CDS ProjectCCDS23266.1
International Mouse Knockout Project StatusFem1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032244 Ensembl Gene Model | MGI Sequence Detail 19817 C57BL/6J ±  kb
transcript ENSMUST00000034775 Ensembl | MGI Sequence Detail 6488 Not Applicable 
polypeptide ENSMUSP00000034775 Ensembl | MGI Sequence Detail 627 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000007455 protein fem-1 homolog B
References (Earliest) J:51387 Ventura-Holman T, et al., The murine fem1 gene family: homologs of the Caenorhabditis elegans sex- determination protein FEM-1. Genomics. 1998 Dec 1;54(2):221-30
(Latest) J:176478 Shi YQ, et al., Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37. Gene. 2011 Oct 10;485(2):153-9
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory