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Fem1b Gene Detail
Summary
  • Symbol
    Fem1b
  • Name
    feminization 1 homolog b (C. elegans)
  • Synonyms
    mKIAA0396
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335087
    NCBI Gene: 14155
Location & Maps
more
  • Sequence Map
    Chr9:62791832-62811648 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19817 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 33.87 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FEM1B, fem-1 homolog B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FEM1B, fem-1 homolog B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    F1AA, F1A-ALPHA, FEM1-beta
  • Links
    NCBI Gene ID: 10116
    neXtProt AC: NX_Q9UK73

  • Chr Location
    15q22; chr15:68277756-68295865 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7714
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FEM1B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Fem1b mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    15
  • Targeted
    4
  • Genomic Mutations
    1 involving Fem1b
  • Incidental Mutations
Homozygous targeted mutants display abnormal glucose tolerance due to defective glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032244 Ensembl Gene Model | MGI Sequence Detail 19817 C57BL/6J ±  kb
transcript ENSMUST00000034775 Ensembl | MGI Sequence Detail 6488 Not Applicable  
polypeptide ENSMUSP00000034775 Ensembl | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    27 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007455 protein fem-1 homolog B
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:51387 Ventura-Holman T, et al., The murine fem1 gene family: homologs of the Caenorhabditis elegans sex- determination protein FEM-1. Genomics. 1998 Dec 1;54(2):221-30
  • Latest
    J:176478 Shi YQ, et al., Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37. Gene. 2011 Oct 10;485(2):153-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory