About   Help   FAQ
Invs
Gene Detail
Symbol

Name
ID
Invs
inversin
MGI:1335082
Feature Type
protein coding gene
Genetic Map
Chromosome 4
26.11 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:48279760-48431954 bp, + strand
From VEGA annotation of GRCm38

  152195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: INVS
Gene Tree: Invs

Human
homologs
INVS, inversin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 27130
neXtProt AC: NX_Q9Y283

Human Synonyms: INV, NPH2, NPHP2

Human Chr (Location): 9q31; chr9:100099185-100338617 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human INVS

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Transgenic mice homozygous for an insertional mutation exhibit complete inversion of the L-R body axis, reversal of embryo turning, complex cardiac anomalies, an abnormally slow turbulent leftward nodal flow, and renal cyst formation. Most succumb to renal failure within 1 week of life.
 
Human Diseases Modeled in Mice Using Invs (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Invs interacts with 309 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process embryonic heart tube left/right pattern formation, kidney development, ...
Component ciliary base, ciliary inversin compartment, ...
Function calmodulin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (94)    Tissues (89)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
Northern blot 11
RT-PCR 9
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase invs ; ZFIN invs    NEW 
Molecular
reagents
All nucleic(63) Genomic(34) cDNA(25) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000006844 (Evidence)
Ensembl Gene Model ENSMUSG00000028344 (Evidence)
Entrez Gene 16348 (Evidence)
DFCI TC1582098, TC1597155, TC1599163, TC1632868
DoTS DT.101161590, DT.101363414, DT.101363415, DT.531286, DT.91370001, DT.94388189
NIA Mouse Gene Index U004303
Consensus CDS Project CCDS18166.1
International Mouse Phenotyping Consortium Status Invs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006844 VEGA Gene Model | MGI Sequence Detail 152195 C57BL/6J ±  kb
transcript OTTMUST00000015833 VEGA | MGI Sequence Detail 5633 Not Applicable 
polypeptide OTTMUSP00000007271 VEGA | MGI Sequence Detail 1062 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(28) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(1068 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000048 IQ motif, EF-hand binding site
Protein Ontology PR:000009079 inversin
References
(Earliest) J:4934 Yokoyama T, et al., Reversal of left-right asymmetry: a situs inversus mutation [see comments]. Science. 1993 Apr 30;260(5108):679-82
(Latest) J:216288 Jones C, et al., Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. Dev Biol. 2014 Nov 1;395(1):62-72
All references(72)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11438, MGI:2140271, MGI:2140572, MGI:96580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory