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Gjd2
Gene Detail
Symbol

Name
ID
Gjd2
gap junction protein, delta 2
MGI:1334209
Synonyms
connexin36, Cx36, Gja9
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.54 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:114009601-114013619 bp, - strand
From VEGA annotation of GRCm38

  4019 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gjd2

Human
homologs
Human Homolog GJD2, gap junction protein, delta 2, 36kDa
NCBI Gene ID 57369
neXtProt AC  NX_Q9UKL4
Human Synonyms  CX36, GJA9
Human Chr (Location)  15q14; chr15:34752441-34754581 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations can cause loss of electrical synapses, impaired synchronous activity of inhibitory networks, altered spike synchrony in OB glomeruli, absent coupling of alpha-ganglion cells in retina, and abnormal cued conditioning, nerve fiber and single cell responses, and insulin secretion.
 
Interactions
Gjd2 interacts with 247 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process action potential, cell-cell signaling, ...
Component cell junction, connexon complex, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (139)    Tissues (35)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 36
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015176 (Evidence)
Ensembl Gene ModelENSMUSG00000068615 (Evidence)
Entrez Gene14617 (Evidence)
UniGene389394
DFCITC1584175
DoTSDT.101121376, DT.91328063, DT.97375632
NIA Mouse Gene IndexU023181
Consensus CDS ProjectCCDS16563.1
International Mouse Knockout Project StatusGjd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015176 VEGA Gene Model | MGI Sequence Detail 4019 C57BL/6J ±  kb
transcript OTTMUST00000035994 VEGA | MGI Sequence Detail 2879 Not Applicable 
polypeptide OTTMUSP00000016163 VEGA | MGI Sequence Detail 321 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000500 Connexin
InterPro IPR017990 Connexin, conserved site
InterPro IPR013092 Connexin, N-terminal
InterPro IPR002260 Gap junction delta-2 protein (Cx36)
InterPro IPR019570 Gap junction protein, cysteine-rich domain
Protein Ontology PR:000008007 gap junction delta-2 protein
References
(Earliest) J:46748 Condorelli DF, et al., Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci. 1998 Mar;10(3):1202-8
(Latest) J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
All references(124)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory