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Gjd2
Gene Detail
Symbol

Name
ID
Gjd2
gap junction protein, delta 2
MGI:1334209
Synonyms
connexin36, Cx36, Gja9
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.54 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:114009601-114013619 bp, - strand
From VEGA annotation of GRCm38

  4019 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7734  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GJD2
Gene Tree: Gjd2

Human
homologs
GJD2, gap junction protein, delta 2, 36kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57369
neXtProt AC: NX_Q9UKL4

Human Synonyms: CX36, GJA9

Human Chr (Location): 15q14; chr15:34752441-34754581 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations can cause loss of electrical synapses, impaired synchronous activity of inhibitory networks, altered spike synchrony in OB glomeruli, absent coupling of alpha-ganglion cells in retina, and abnormal cued conditioning, nerve fiber and single cell responses, and insulin secretion.
 
Interactions
Gjd2 interacts with 246 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process action potential, cell-cell signaling, ...
Component cell junction, connexon complex, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (140)    Tissues (36)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 36
RT-PCR 1
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GJD2 ZFIN cx35b    NEW 
Molecular
reagents
All nucleic(12) Genomic(3) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015176 (Evidence)
Ensembl Gene Model ENSMUSG00000068615 (Evidence)
Entrez Gene 14617 (Evidence)
UniGene 389394
DFCI TC1584175
DoTS DT.101121376, DT.91328063, DT.97375632
NIA Mouse Gene Index U023181
Consensus CDS Project CCDS16563.1
International Mouse Phenotyping Consortium Status Gjd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015176 VEGA Gene Model | MGI Sequence Detail 4019 C57BL/6J ±  kb
transcript OTTMUST00000035994 VEGA | MGI Sequence Detail 2879 Not Applicable 
polypeptide OTTMUSP00000016163 VEGA | MGI Sequence Detail 321 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000500 Connexin
InterPro IPR017990 Connexin, conserved site
InterPro IPR013092 Connexin, N-terminal
InterPro IPR002260 Gap junction delta-2 protein (Cx36)
InterPro IPR019570 Gap junction protein, cysteine-rich domain
Protein Ontology PR:000008007 gap junction delta-2 protein
References
(Earliest) J:46748 Condorelli DF, et al., Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci. 1998 Mar;10(3):1202-8
(Latest) J:220845 Lebreton F, et al., Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells. Diabetologia. 2015 Jun;58(6):1291-9
All references(129)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory