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Pde3b
Gene Detail
 Symbol
Name
ID
Pde3b
phosphodiesterase 3B, cGMP-inhibited
MGI:1333863
Synonyms 9830102A01Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
59.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:114415281-114539251 bp, + strand
From VEGA annotation of GRCm38

  123971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclic-nucleotide phosphodiesterase, cGMP-inhibited
Gene Tree: Pde3b

Human
homologs
Human Homolog PDE3B, phosphodiesterase 3B, cGMP-inhibited
NCBI Gene ID 5140
neXtProt AC  NX_Q13370
Human Synonyms  cGIPDE1, HcGIP1
Human Chr (Location)  11p15.1; chr11:14643645-14872059 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants show abnormalities in glycerol and fatty acid levels, along with changes in adipocyte morphology and decreased body fat percentage.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process angiogenesis, cAMP catabolic process, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (96)    Tissues (96)    Images (13)
Theiler Stages: 22, 24
Assay TypeResults
RNA in situ 96
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025593 (Evidence)
Ensembl Gene ModelENSMUSG00000030671 (Evidence)
Entrez Gene18576 (Evidence)
DFCITC1581500, TC1600419, TC1693466
DoTSDT.110999698, DT.55213403, DT.91366520, DT.91562223, DT.91575435, DT.97361407
NIA Mouse Gene IndexU008656
EC3.1.4.17
Consensus CDS ProjectCCDS21760.1
International Mouse Knockout Project StatusPde3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025593 VEGA Gene Model | MGI Sequence Detail 123971 C57BL/6J ±  kb
transcript OTTMUST00000062959 VEGA | MGI Sequence Detail 6573 Not Applicable 
polypeptide OTTMUSP00000031097 VEGA | MGI Sequence Detail 1099 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(1048 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012471 cGMP-inhibited 3',5'-cyclic phosphodiesterase B
References (Earliest) J:36022 Lobbert RW, et al., Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1. Genomics. 1996 Oct 15;37(2):211-8
(Latest) J:207678 Ohno H, et al., EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013 Dec 5;504(7478):163-7
All references(52)
Other
accession IDs
MGI:2142046, MGI:2441760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory