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Pde3b Gene Detail
Summary
  • Symbol
    Pde3b
  • Name
    phosphodiesterase 3B, cGMP-inhibited
  • Synonyms
    9830102A01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333863
    NCBI Gene: 18576
Location & Maps
more
  • Sequence Map
    Chr7:114415281-114539251 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123971 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PDE3B, phosphodiesterase 3B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDE3B, phosphodiesterase 3B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cGIPDE1, HcGIP1
  • Links
    NCBI Gene ID: 5140
    neXtProt AC: NX_Q13370

  • Chr Location
    11p15.1; chr11:14643656-14872059 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Pde3b
  • Incidental Mutations
Mutants show abnormalities in glycerol and fatty acid levels, along with changes in adipocyte morphology and decreased body fat percentage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025593 VEGA Gene Model | MGI Sequence Detail 123971 C57BL/6J ±  kb
transcript OTTMUST00000062959 VEGA | MGI Sequence Detail 6573 Not Applicable  
polypeptide OTTMUSP00000031097 VEGA | MGI Sequence Detail 1099 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1048 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2142046, MGI:2441760
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:36022 Lobbert RW, et al., Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1. Genomics. 1996 Oct 15;37(2):211-8
  • Latest
    J:221108 Chung YW, et al., Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2253-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory