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Cx3cr1 Gene Detail
Summary
  • Symbol
    Cx3cr1
  • Name
    chemokine (C-X3-C motif) receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333815
    NCBI Gene: 13051
  • Gene Overview
    MyGene.info: CX3CR1
Location & Maps
more
  • Sequence Map
    Chr9:120048683-120068296 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19614 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.37 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CX3CR1, C-X3-C motif chemokine receptor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CX3CR1, C-X3-C motif chemokine receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
  • Links
    NCBI Gene ID: 1524
    neXtProt AC: NX_P49238

  • Chr Location
    3p21.3; chr3:39263494-39281735 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cx3cr1 mouse models; 3 with human CX3CR1 associations

Human Disease Mouse Models
       Macular Degeneration, Age-Related, 12; ARMD12   OMIM: 613784 View 4 models
       Coronary Heart Disease, Susceptibility to, 1   OMIM: 607339
Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 4 alleles in 10 genetic backgrounds
    35 phenotypes from multigenic genotypes
    4 images
    338 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Age related retinal degeneration with abnormal subretinal microglial cell accumulation in one homozygous null mice. Other null mice shows impaired monocyte recruitment after vascular injury, kidney ischemia and reperfusion, and bacterial infection of the instestine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13051 NCBI Gene Model | MGI Sequence Detail 19614 C57BL/6J ±  kb
transcript NM_009987 RefSeq | MGI Sequence Detail 3753 C57BL/6  
polypeptide Q9Z0D9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    243 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001206 CX3C chemokine receptor 1
  • InterPro Domains
    IPR005387 CX3C chemokine receptor 1
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 5
References
more
  • Summaries
    All 373
    Developmental Gene Expression 13
    Diseases 3
    Gene Ontology 7
    Phenotypes 338
  • Earliest
    J:51793 Combadiere C, et al., Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 1998 Dec 30;253(3):728-32
  • Latest
    J:232107 Yang J, et al., Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory