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Cx3cr1 Gene Detail
Summary
  • Symbol
    Cx3cr1
  • Name
    chemokine (C-X3-C motif) receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333815
    NCBI Gene: 13051
  • Gene Overview
    MyGene.info: CX3CR1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:120048683-120068296 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19614 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.37 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CX3CR1, C-X3-C motif chemokine receptor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CX3CR1, C-X3-C motif chemokine receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
  • Links
    NCBI Gene ID: 1524
    neXtProt AC: NX_P49238
    UniProt: P49238

  • Chr Location
    3p22.2; chr3:39263494-39281735 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cx3cr1 mouse models; 3 with human CX3CR1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 5 alleles in 11 genetic backgrounds
    34 phenotypes from multigenic genotypes
    4 images
    527 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Age related retinal degeneration with abnormal subretinal microglial cell accumulation in one homozygous null mice. Other null mice shows impaired monocyte recruitment after vascular injury, kidney ischemia and reperfusion, and bacterial infection of the instestine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13051 NCBI Gene Model | MGI Sequence Detail 19614 C57BL/6J ±  kb
    transcript NM_009987 RefSeq | MGI Sequence Detail 3753 C57BL/6  
    polypeptide Q9Z0D9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      243 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 9

      Microarray probesets 5
    References
    more
    • Summaries
      All 586
      Developmental Gene Expression 22
      Diseases 3
      Gene Ontology 11
      Phenotypes 527
    • Earliest
      J:51793 Combadiere C, et al., Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 1998 Dec 30;253(3):728-32
    • Latest
      J:265439 Lau A, et al., Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury. J Clin Invest. 2018 Jul 2;128(7):2894-2913

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory