Cx3cr1
Gene Detail

Symbol Name ID

Cx3cr1 chemokine (C-X3-C) receptor 1 MGI:1333815

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:120048693-120068282 bp, - strand From NCBI annotation of GRCm38   19590 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Cx3cr1

Human homologs

Human Homolog		CX3CR1, chemokine (C-X3-C motif) receptor 1
NCBI Gene ID		1524
neXtProt AC		NX_P49238
Human Synonyms		CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
Human Chr (Location)		3p21.3; chr3:39304985-39323226 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CX3CR1

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Age related retinal degeneration with abnormal subretinal microglial cell accumulation in one homozygous null mice. Other null mice shows impaired monocyte recruitment after vascular injury, kidney ischemia and reperfusion, and bacterial infection of the instestine.

 
Human Diseases Modeled Using Mouse Cx3cr1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell adhesion, cerebral cortex cell migration, ...
Component	integral to membrane, membrane, ...
Function	C-X3-C chemokine receptor activity, cytokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (50)    Tissues (17)    Images (29)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	48
In situ reporter (knock in)	2

cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000052336 (Evidence)
Entrez Gene	13051 (Evidence)
UniGene	44065
DFCI	TC1580957
DoTS	DT.40138746, DT.91417538
NIA Mouse Gene Index	U031439
Consensus CDS Project	CCDS40806.1
International Mouse Knockout Project Status	Cx3cr1

Sequences

Length	Strain/Species
genomic	13051	NCBI Gene Model | MGI Sequence Detail	19590	C57BL/6J
transcript	NM_009987	RefSeq | MGI Sequence Detail	3753	C57BL/6
polypeptide	Q9Z0D9	UniProt | EBI | MGI Sequence Detail	354	Not Applicable

All sequences(25) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005387	CX3C chemokine fractalkine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001206	CX3C chemokine receptor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:51793 Combadiere C, et al., Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 1998 Dec 30;253(3):728-32
(Latest) J:194962 Fumagalli S, et al., CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia. 2013 Jun;61(6):827-42
All references(214)