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Cx3cr1
Gene Detail
Symbol

Name
ID
Cx3cr1
chemokine (C-X3-C motif) receptor 1
MGI:1333815
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:120048693-120068282 bp, - strand
From NCBI annotation of GRCm38

  19590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Cx3cr1

Human
homologs
Human Homolog CX3CR1, chemokine (C-X3-C motif) receptor 1
NCBI Gene ID 1524
neXtProt AC  NX_P49238
Human Synonyms  CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
Human Chr (Location)  3p21.3; chr3:39263494-39281735 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human CX3CR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Age related retinal degeneration with abnormal subretinal microglial cell accumulation in one homozygous null mice. Other null mice shows impaired monocyte recruitment after vascular injury, kidney ischemia and reperfusion, and bacterial infection of the instestine.
 
Human Diseases Modeled Using Mouse Cx3cr1 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Cx3cr1 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell adhesion, cerebral cortex cell migration, ...
Component integral component of membrane, membrane, ...
Function chemokine receptor activity, C-X3-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (50)    Tissues (17)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
In situ reporter (knock in) 2
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000052336 (Evidence)
Entrez Gene13051 (Evidence)
DFCITC1580957
DoTSDT.40138746, DT.91417538
NIA Mouse Gene IndexU031439
Consensus CDS ProjectCCDS40806.1
International Mouse Knockout Project StatusCx3cr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13051 NCBI Gene Model | MGI Sequence Detail 19590 C57BL/6J ±  kb
transcript NM_009987 RefSeq | MGI Sequence Detail 3753 C57BL/6 
polypeptide Q9Z0D9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(243 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR005387 CX3C chemokine receptor 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001206 CX3C chemokine receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:51793 Combadiere C, et al., Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 1998 Dec 30;253(3):728-32
(Latest) J:212753 Old EA, et al., Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. J Clin Invest. 2014 May 1;124(5):2023-36
All references(285)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory