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Cx3cr1
Gene Detail
Symbol

Name
ID
Cx3cr1
chemokine (C-X3-C motif) receptor 1
MGI:1333815
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:120048683-120068296 bp, - strand
From NCBI annotation of GRCm38

  19614 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CX3CR1
Protein SuperFamily: chemokine receptor
Gene Tree: Cx3cr1

Human
homologs
CX3CR1, chemokine (C-X3-C motif) receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1524
neXtProt AC: NX_P49238

Human Synonyms: CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28

Human Chr (Location): 3p21.3; chr3:39263494-39281735 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CX3CR1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Age related retinal degeneration with abnormal subretinal microglial cell accumulation in one homozygous null mice. Other null mice shows impaired monocyte recruitment after vascular injury, kidney ischemia and reperfusion, and bacterial infection of the instestine.
 
Human Diseases Modeled in Mice Using Cx3cr1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Cx3cr1 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell adhesion, cerebral cortex cell migration, ...
Component integral component of membrane, membrane, ...
Function chemokine receptor activity, C-X3-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (50)    Tissues (17)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
In situ reporter (knock in) 2
cDNA source data(8)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000052336 (Evidence)
Entrez Gene 13051 (Evidence)
DFCI TC1580957
DoTS DT.91417538, DT.40138746
NIA Mouse Gene Index U031439
Consensus CDS Project CCDS40806.1
International Mouse Phenotyping Consortium Status Cx3cr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13051 NCBI Gene Model | MGI Sequence Detail 19614 C57BL/6J ±  kb
transcript NM_009987 RefSeq | MGI Sequence Detail 3753 C57BL/6 
polypeptide Q9Z0D9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(243 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR005387 CX3C chemokine receptor 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001206 CX3C chemokine receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:51793 Combadiere C, et al., Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 1998 Dec 30;253(3):728-32
(Latest) J:221887 Aychek T, et al., IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology. Nat Commun. 2015;6:6525
All references(331)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory