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Mbd3 Gene Detail
Summary
  • Symbol
    Mbd3
  • Name
    methyl-CpG binding domain protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333812
    NCBI Gene: 17192
  • Gene Overview
    MyGene.info: MBD3
Location & Maps
more
  • Sequence Map
    Chr10:80392539-80399550 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7012 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MBD3, methyl-CpG binding domain protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MBD3, methyl-CpG binding domain protein 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 53615
    neXtProt AC: NX_O95983

  • Chr Location
    19p13.3; chr19:1576671-1592761 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    154
  • Chemically induced (other)
    1
  • Gene trapped
    149
  • Targeted
    4
  • Genomic Mutations
    1 involving Mbd3
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene experience deficiencies as embryos around implantation and die before birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019125 VEGA Gene Model | MGI Sequence Detail 7012 C57BL/6J ±  kb
transcript OTTMUST00000045811 VEGA | MGI Sequence Detail 1662 Not Applicable  
polypeptide OTTMUSP00000020630 VEGA | MGI Sequence Detail 285 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010216 methyl-CpG-binding domain protein 3
  • InterPro Domains
    IPR016177 DNA-binding domain
    IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region
    IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain
    IPR001739 Methyl-CpG DNA binding
Molecular
Reagents
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  • All nucleic 120
    cDNA 116
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143531, MGI:2143734
References
more
  • Summaries
    All 59
    Developmental Gene Expression 10
    Gene Ontology 12
    Phenotypes 17
  • Earliest
    J:50520 Hendrich B, et al., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47
  • Latest
    J:222255 Knock E, et al., The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex. Neural Dev. 2015;10:13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory