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Mbd3 Gene Detail
Summary
  • Symbol
    Mbd3
  • Name
    methyl-CpG binding domain protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333812
    NCBI Gene: 17192
  • Gene Overview
    MyGene.info: MBD3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80392539-80399531 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333812
protein coding gene Chr10:80392539-80399550 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017501
protein coding gene Chr10:80995244-81002256 (-)
A/J MGP_AJ_G0017479
protein coding gene Chr10:78160547-78167548 (-)
AKR/J MGP_AKRJ_G0017440
protein coding gene Chr10:80303581-80310600 (-)
BALB/cJ MGP_BALBcJ_G0017441
protein coding gene Chr10:78392012-78399018 (-)
C3H/HeJ MGP_C3HHeJ_G0017264
protein coding gene Chr10:80392609-80399603 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017895
protein coding gene Chr10:83798025-83805034 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015583
protein coding gene Chr10:74380160-74387466 (-)
CAST/EiJ MGP_CASTEiJ_G0016831
protein coding gene Chr10:80607991-80615193 (-)
CBA/J MGP_CBAJ_G0017236
protein coding gene Chr10:87045178-87052189 (-)
DBA/2J MGP_DBA2J_G0017342
protein coding gene Chr10:77378543-77385899 (-)
FVB/NJ MGP_FVBNJ_G0017336
protein coding gene Chr10:76577721-76584733 (-)
LP/J MGP_LPJ_G0017413
protein coding gene Chr10:81471596-81480081 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017362
protein coding gene Chr10:88990820-88997833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017936
protein coding gene Chr10:80288884-80295885 (-)
PWK/PhJ MGP_PWKPhJ_G0016612
protein coding gene Chr10:77256623-77263649 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016401
protein coding gene Chr10:79259647-79266635 (-)
WSB/EiJ MGP_WSBEiJ_G0016891
protein coding gene Chr10:80326210-80333209 (-)



Homology
more
  • Human Ortholog
    MBD3, methyl-CpG binding domain protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MBD3, methyl-CpG binding domain protein 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 53615
    neXtProt AC: NX_O95983
    UniProt: O95983

  • Chr Location
    19p13.3; chr19:1576671-1592761 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience deficiencies as embryos around implantation and die before birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17192 NCBI Gene Model | MGI Sequence Detail 6993 C57BL/6J ±  kb
    transcript NM_013595 RefSeq | MGI Sequence Detail 1659 C57BL/6  
    polypeptide Q9Z2D8 UniProt | EBI | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 117
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143531, MGI:2143734
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 12
      Gene Ontology 14
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266522 Elsen GE, et al., The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory