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Aqp3 Gene Detail
Summary
  • Symbol
    Aqp3
  • Name
    aquaporin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333777
    NCBI Gene: 11828
  • Gene Overview
    MyGene.info: AQP3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41092724-41098183 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 20.94 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333777
protein coding gene Chr4:41092722-41098183 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028154
protein coding gene Chr4:39014823-39020280 (-)
A/J MGP_AJ_G0028112
protein coding gene Chr4:37538215-37543677 (-)
AKR/J MGP_AKRJ_G0028075
protein coding gene Chr4:38500987-38506448 (-)
BALB/cJ MGP_BALBcJ_G0028124
protein coding gene Chr4:37868345-37873802 (-)
C3H/HeJ MGP_C3HHeJ_G0027852
protein coding gene Chr4:39042548-39048006 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028565
protein coding gene Chr4:40459119-40464573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025906
protein coding gene Chr4:35189733-35195216 (-)
CAST/EiJ MGP_CASTEiJ_G0027308
protein coding gene Chr4:38708073-38713612 (-)
CBA/J MGP_CBAJ_G0027824
protein coding gene Chr4:41836745-41842197 (-)
DBA/2J MGP_DBA2J_G0027968
protein coding gene Chr4:37457231-37462931 (-)
FVB/NJ MGP_FVBNJ_G0027935
protein coding gene Chr4:36791196-36796656 (-)
LP/J MGP_LPJ_G0028076
protein coding gene Chr4:39079067-39084528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027968
protein coding gene Chr4:45157027-45162477 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028624
protein coding gene Chr4:38616188-38621647 (-)
PWK/PhJ MGP_PWKPhJ_G0027027
protein coding gene Chr4:37424166-37473212 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026854
protein coding gene Chr4:38318613-38324082 (-)
WSB/EiJ MGP_WSBEiJ_G0027384
protein coding gene Chr4:38584963-38590424 (-)



Homology
more
  • Human Ortholog
    AQP3, aquaporin 3 (Gill blood group)
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AQP3, aquaporin 3 (Gill blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AQP-3, GIL
  • Links
    NCBI Gene ID: 360
    neXtProt AC: NX_Q92482
    UniProt: Q92482

  • Chr Location
    9p13.3; chr9:33441154-33447633 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21025
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AQP3
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Aqp3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene display increased drinking behavior, increased urination, and decreased urine osmolality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11828 NCBI Gene Model | MGI Sequence Detail 5460 C57BL/6J ±  kb
    transcript NM_016689 RefSeq | MGI Sequence Detail 1763 C57BL/6  
    polypeptide Q8R2N1 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 16
      Phenotypes 39
    • Earliest
      J:42704 Ma T, et al., Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997 Sep 1;100(5):957-62
    • Latest
      J:255227 Lei L, et al., Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochim Biophys Acta. 2017 Jun;1863(6):1231-1241

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory