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Aqp3
Gene Detail
Symbol

Name
ID
Aqp3
aquaporin 3
MGI:1333777
Feature Type
protein coding gene
Genetic Map
Chromosome 4
20.94 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:41092722-41098183 bp, - strand
From VEGA annotation of GRCm38

  5462 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21025  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: AQP3
Protein SuperFamily: aquaporin
Gene Tree: Aqp3

Human
homologs
AQP3, aquaporin 3 (Gill blood group)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 360
neXtProt AC: NX_Q92482

Human Synonyms: AQP-3, GIL

Human Chr (Location): 9p13; chr9:33441154-33447633 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(14) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation in this gene display increased drinking behavior, increased urination, and decreased urine osmolality.
 
Human Diseases Modeled in Mice Using Aqp3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Aqp3 interacts with 107 markers (Mir7-1, Mir101a, Mir101b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process carbohydrate transmembrane transport, cellular water homeostasis, ...
Component basolateral plasma membrane, cell, ...
Function glycerol channel activity, transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (66)    Tissues (37)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 14
Western blot 14
RT-PCR 27
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aqp3    NEW 
Molecular
reagents
All nucleic(17) cDNA(14) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006621 (Evidence)
Ensembl Gene Model ENSMUSG00000028435 (Evidence)
Entrez Gene 11828 (Evidence)
UniGene 34043
DFCI TC1581645, TC1595433
DoTS DT.94126511, DT.97368948
NIA Mouse Gene Index U024966
Consensus CDS Project CCDS38714.1
International Mouse Phenotyping Consortium Status Aqp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006621 VEGA Gene Model | MGI Sequence Detail 5462 C57BL/6J ±  kb
transcript OTTMUST00000015099 VEGA | MGI Sequence Detail 1765 Not Applicable 
polypeptide OTTMUSP00000006982 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023275 Aquaporin 3
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000004183 aquaporin-3
References
(Earliest) J:42704 Ma T, et al., Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997 Sep 1;100(5):957-62
(Latest) J:223017 Hara-Chikuma M, et al., Aquaporin-3-mediated hydrogen peroxide transport is required for NF-kappaB signalling in keratinocytes and development of psoriasis. Nat Commun. 2015;6:7454
All references(88)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory