Aqp3
Gene Detail

Symbol Name ID

Aqp3 aquaporin 3 MGI:1333777

Feature Type

protein coding gene

Genetic Map

Chromosome 4

20.94 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:41092722-41098183 bp, - strand From VEGA annotation of GRCm38   5462 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21025  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: aquaporin
Gene Tree: Aqp3

Human homologs

Human Homolog		AQP3, aquaporin 3 (Gill blood group)
NCBI Gene ID		360
neXtProt AC		NX_Q92482
Human Synonyms		AQP-3, GIL
Human Chr (Location)		9p13; chr9:33441152-33447631 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(4) Gene trapped(14) Chemically induced(1)
 

Animals homozygous for a mutation in this gene display increased drinking behavior, increased urination, and decreased urine osmolality.

 
Human Diseases Modeled Using Mouse Aqp3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	glycerol transport, positive regulation of immune system process, ...
Component	basolateral plasma membrane, cell-cell junction, ...
Function	glycerol channel activity, transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (55)    Tissues (22)    Images (1)
Theiler Stages: 2, 3, 4, 5, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
Western blot	14
RT-PCR	38

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(14) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006621 (Evidence)
Ensembl Gene Model	ENSMUSG00000028435 (Evidence)
Entrez Gene	11828 (Evidence)
UniGene	34043
DFCI	TC1581645, TC1595433
DoTS	DT.94126511, DT.97368948
NIA Mouse Gene Index	U024966
Consensus CDS Project	CCDS38714.1
International Mouse Knockout Project Status	Aqp3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006621	VEGA Gene Model | MGI Sequence Detail	5462	C57BL/6J
transcript	OTTMUST00000015099	VEGA | MGI Sequence Detail	1765	Not Applicable
polypeptide	OTTMUSP00000006982	VEGA | MGI Sequence Detail	292	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023275	Aquaporin 3
InterPro	IPR023271	Aquaporin-like
InterPro	IPR000425	Major intrinsic protein
InterPro	IPR022357	Major intrinsic protein, conserved site
Protein Ontology	PR:000004183	aquaporin-3

References

(Earliest) J:42704 Ma T, et al., Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997 Sep 1;100(5):957-62
(Latest) J:192934 Hara-Chikuma M, et al., Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J Exp Med. 2012 Sep 24;209(10):1743-52
All references(84)