About   Help   FAQ
Krt6b Gene Detail
Summary
  • Symbol
    Krt6b
  • Name
    keratin 6B
  • Synonyms
    Krt2-6b, mK6[b]
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333768
    NCBI Gene: 16688
  • Member of
    Krt6 cluster
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101676023-101680287 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333768
protein coding gene Chr15:101676023-101680289 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0022344
protein coding gene Chr15:99685477-99718521 (-)
AKR/J MGP_AKRJ_G0022319
protein coding gene Chr15:102722748-102728256 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0020320
protein coding gene Chr15:95514629-95518874 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0022214
protein coding gene Chr15:99009084-99016451 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0022284
protein coding gene Chr15:103947665-103957413 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021212
protein coding gene Chr15:102585945-102597008 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KRT6A, keratin 6A
  • Vertebrate Orthologs
    4
  • Human Ortholog
    KRT6A, keratin 6A
    Orthology source: HGNC
  • Synonyms
    CK6A, CK6C, CK-6C, CK6D, CK-6E, K6A, K6C, K6D, KRT6C, KRT6D, PC3
  • Links
    NCBI Gene ID: 3853
    neXtProt AC: NX_P02538
    UniProt: P02538

  • Chr Location
    12q13.13; chr12:52487174-52493397 (-)  GRCh38.p7

  • Human Ortholog
    KRT6B, keratin 6B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CK6B, CK-6B, K6B, KRTL1, PC2, PC4
  • Links
    NCBI Gene ID: 3854
    neXtProt AC: NX_P04259
    UniProt: P04259

  • Chr Location
    12q13.13; chr12:52446651-52452126 (-)  GRCh38.p7

  • Human Ortholog
    KRT6C, keratin 6C
    Orthology source: HGNC
  • Synonyms
    K6E, KRT6E, PPKNEFD
  • Links
    NCBI Gene ID: 286887
    neXtProt AC: NX_P48668
    UniProt: P48668

  • Chr Location
    12q13.13; chr12:52468516-52473785 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KRT6C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    3 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023041 Ensembl Gene Model | MGI Sequence Detail 4265 C57BL/6J ±  kb
    transcript ENSMUST00000023786 Ensembl | MGI Sequence Detail 2235 Not Applicable  
    polypeptide ENSMUSP00000023786 Ensembl | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001664 Intermediate filament protein
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR003054 Keratin, type II
      IPR032444 Keratin type II head
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 9
      cDNA 11
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146263
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 1
      Phenotypes 28
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory