Krt6b
Gene Detail

Symbol Name ID

Krt6b keratin 6B MGI:1333768

Synonyms

Krt2-6b, mK6[b]

Feature Type

protein coding gene

Genetic Map

Chromosome 15

56.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:101676034-101680289 bp, - strand From Ensembl annotation of GRCm38   4256 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36182  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee; 1 rhesus macaque; 3 cattle; 2 dog

Gene Tree: Krt6b

Human homologs

Human Homolog		KRT6A, keratin 6A
NCBI Gene ID		3853
neXtProt AC		NX_P02538
Human Synonyms		CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D
Human Chr (Location)		12q13.13; chr12:52880958-52887181 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KRT6A

Alleles and phenotypes

All alleles(2) : Targeted(2)
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	intermediate filament organization, keratinization, ...
Component	intermediate filament

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (3)    Tissues (1)    Images (1)
Theiler Stages: 20

Assay Type	Results
RT-PCR	3

cDNA source data(11)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(9) cDNA(11) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023041 (Evidence)
Entrez Gene	16688 (Evidence)
UniGene	441891
DFCI	TC1600985
DoTS	DT.110836260, DT.87078531, DT.97371888
NIA Mouse Gene Index	U066711
Consensus CDS Project	CCDS27859.1
International Mouse Knockout Project Status	Krt6b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023041	Ensembl Gene Model | MGI Sequence Detail	4256	C57BL/6J
transcript	ENSMUST00000023786	Ensembl | MGI Sequence Detail	2226	Not Applicable
polypeptide	ENSMUSP00000023786	Ensembl | MGI Sequence Detail	554	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR003054	Type II keratin
Protein Ontology	PR:000009483	keratin, type II cytoskeletal 6B

References

(Earliest) J:50536 Takahashi K, et al., The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs. Genomics. 1998 Oct 15;53(2):170-83
(Latest) J:143315 Wang X, et al., AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol. 2008 Oct 6;183(1):37-48
All references(38)

Other accession IDs

MGI:2146263