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Krt6b
Gene Detail
Symbol

Name
ID
Member of
Krt6b
keratin 6B
MGI:1333768
Krt6 cluster
Synonyms
Krt2-6b, mK6[b]
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:101676034-101680289 bp, - strand
From Ensembl annotation of GRCm38

  4256 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136794  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee

Gene Tree: Krt6b

Human
homologs
Human Homolog KRT6B, keratin 6B
NCBI Gene ID 3854
neXtProt AC  NX_P04259
Human Synonyms  CK6B, CK-6B, K6B, KRTL1, PC2, PC4
Human Chr (Location)  12q13.13; chr12:52446651-52452126 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KRT6B
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Krt6b (2)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Krt6b interacts with 101 markers (Mir15a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process intermediate filament organization, keratinization, ...
Component extracellular vesicular exosome
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (3)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(9) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023041 (Evidence)
Entrez Gene16688 (Evidence)
UniGene441891
DFCITC1600985
DoTSDT.97371888, DT.87078531, DT.110836260
NIA Mouse Gene IndexU066711
Consensus CDS ProjectCCDS27859.1
International Mouse Knockout Project StatusKrt6b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023041 Ensembl Gene Model | MGI Sequence Detail 4256 C57BL/6J ±  kb
transcript ENSMUST00000023786 Ensembl | MGI Sequence Detail 2226 Not Applicable 
polypeptide ENSMUSP00000023786 Ensembl | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)    SNPs within 2kb including multiple locations(43)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR009053 Prefoldin
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009483 keratin, type II cytoskeletal 6B
References
(Earliest) J:50536 Takahashi K, et al., The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs. Genomics. 1998 Oct 15;53(2):170-83
(Latest) J:198837 Cui CY, et al., Frizzled6 deficiency disrupts the differentiation process of nail development. J Invest Dermatol. 2013 Aug;133(8):1990-7
All references(39)
Other
accession IDs
MGI:2146263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory