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Epn2 Gene Detail
Summary
  • Symbol
    Epn2
  • Name
    epsin 2
  • Synonyms
    9530051D10Rik, Ibp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333766
    NCBI Gene: 13855
  • Gene Overview
    MyGene.info: EPN2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61517249-61579687 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333766
protein coding gene Chr11:61517249-61579719 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018442
protein coding gene Chr11:61481835-61543484 (-)
A/J MGP_AJ_G0018411
protein coding gene Chr11:59211822-59273695 (-)
AKR/J MGP_AKRJ_G0018381
protein coding gene Chr11:61053689-61115306 (-)
BALB/cJ MGP_BALBcJ_G0018382
protein coding gene Chr11:59517291-59579894 (-)
C3H/HeJ MGP_C3HHeJ_G0018195
protein coding gene Chr11:61035770-61098529 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018834
protein coding gene Chr11:63432312-63497256 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016480
protein coding gene Chr11:56337659-56395693 (-)
CAST/EiJ MGP_CASTEiJ_G0017752
protein coding gene Chr11:61140461-61204740 (-)
CBA/J MGP_CBAJ_G0018169
protein coding gene Chr11:66180536-66244590 (-)
DBA/2J MGP_DBA2J_G0018278
protein coding gene Chr11:58785674-58847459 (-)
FVB/NJ MGP_FVBNJ_G0018269
protein coding gene Chr11:58470455-58532097 (-)
LP/J MGP_LPJ_G0018351
protein coding gene Chr11:62052243-62115082 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018293
protein coding gene Chr11:67196548-67259794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018875
protein coding gene Chr11:61188971-61252032 (-)
PWK/PhJ MGP_PWKPhJ_G0017525
protein coding gene Chr11:59381176-59447352 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017315
protein coding gene Chr11:61012644-61074439 (-)
WSB/EiJ MGP_WSBEiJ_G0017804
protein coding gene Chr11:60795158-60856816 (-)



Homology
more
  • Human Ortholog
    EPN2, epsin 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EPN2, epsin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EHB21
  • Links
    NCBI Gene ID: 22905
    neXtProt AC: NX_O95208
    UniProt: O95208

  • Chr Location
    17p11.2; chr17:19237377-19336715 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotypes from multigenic genotypes
    7 images
    20 phenotype references
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities. Mice homozygous null for both Epn1 and Epn2 display defects in angiogenic vascular remodeling, impaired somitogenesis and extensive cell death in the nervous tissue, resulting in lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001036 Ensembl Gene Model | MGI Sequence Detail 62439 C57BL/6J ±  kb
transcript ENSMUST00000179936 Ensembl | MGI Sequence Detail 4452 Not Applicable  
polypeptide ENSMUSP00000136950 Ensembl | MGI Sequence Detail 640 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
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MGI:1925919, MGI:2144024
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:266192 Wu H, et al., Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes. J Clin Invest. 2018 Aug 31;128(9):4025-4043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory