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Epn2 Gene Detail
Summary
  • Symbol
    Epn2
  • Name
    epsin 2
  • Synonyms
    9530051D10Rik, Ibp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333766
    NCBI Gene: 13855
  • Gene Overview
    MyGene.info: EPN2
Location & Maps
more
  • Sequence Map
    Chr11:61517249-61579685 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62437 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EPN2, epsin 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EPN2, epsin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EHB21
  • Links
    NCBI Gene ID: 22905
    neXtProt AC: NX_O95208

  • Chr Location
    17p11.2; chr17:19237377-19336715 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotypes from multigenic genotypes
    7 images
    17 phenotype references
  • All Mutations and Alleles
    67
  • Chemically induced (other)
    1
  • Gene trapped
    62
  • Targeted
    4
  • Genomic Mutations
    1 involving Epn2
  • Incidental Mutations
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities. Mice homozygous null for both Epn1 and Epn2 display defects in angiogenic vascular remodeling, impaired somitogenesis and extensive cell death in the nervous tissue, resulting in lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005838 VEGA Gene Model | MGI Sequence Detail 62437 C57BL/6J ±  kb
transcript OTTMUST00000012984 VEGA | MGI Sequence Detail 4458 Not Applicable  
polypeptide OTTMUSP00000006037 VEGA | MGI Sequence Detail 634 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    210 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 6
Other
Accession IDs
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MGI:1925919, MGI:2144024
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:51614 Yamabhai M, et al., Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem. 1998 Nov 20;273(47):31401-7
  • Latest
    J:229826 Dong Y, et al., Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2015 Dec;125(12):4349-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory