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Mapkapk5 Gene Detail
Summary
  • Symbol
    Mapkapk5
  • Name
    MAP kinase-activated protein kinase 5
  • Synonyms
    MK5, PRAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333110
    NCBI Gene: 17165
  • Gene Overview
    MyGene.info: MAPKAPK5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121525051-121545892 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 61.84 cM, cytoband F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333110
protein coding gene Chr5:121525038-121545905 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030032
protein coding gene Chr5:125017856-125041949 (-)
A/J MGP_AJ_G0029997
protein coding gene Chr5:119868944-119890485 (-)
AKR/J MGP_AKRJ_G0029933
protein coding gene Chr5:123745265-123765773 (-)
BALB/cJ MGP_BALBcJ_G0030008
protein coding gene Chr5:121255445-121275801 (-)
C3H/HeJ MGP_C3HHeJ_G0029725
protein coding gene Chr5:124313155-124341792 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030461
protein coding gene Chr5:129776264-129801674 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027687
protein coding gene Chr5:114543360-114563207 (-)
CAST/EiJ MGP_CASTEiJ_G0029134
protein coding gene Chr5:123422778-123447528 (-)
CBA/J MGP_CBAJ_G0029695
protein coding gene Chr5:134880881-134913456 (-)
DBA/2J MGP_DBA2J_G0029845
protein coding gene Chr5:119938329-119959319 (-)
FVB/NJ MGP_FVBNJ_G0029801
protein coding gene Chr5:118893747-118916581 (-)
LP/J MGP_LPJ_G0029934
protein coding gene Chr5:125531393-125558570 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029832
protein coding gene Chr5:138732613-138756534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030502
protein coding gene Chr5:123267009-123293194 (-)
PWK/PhJ MGP_PWKPhJ_G0028848
protein coding gene Chr5:118715144-118735979 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028685
protein coding gene Chr5:121025230-121045273 (-)
WSB/EiJ MGP_WSBEiJ_G0029209
protein coding gene Chr5:123921298-123942273 (-)



Homology
more
  • Human Ortholog
    MAPKAPK5, mitogen-activated protein kinase-activated protein kinase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPKAPK5, mitogen-activated protein kinase-activated protein kinase 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MAPKAP-K5, MK5, MK-5, PRAK
  • Links
    NCBI Gene ID: 8550
    neXtProt AC: NX_Q8IW41
    UniProt: Q8IW41

  • Chr Location
    12q24.12-q24.13; chr12:111842228-111902225 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile, and show no overt abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17165 NCBI Gene Model | MGI Sequence Detail 20842 C57BL/6J ±  kb
    transcript NM_010765 RefSeq | MGI Sequence Detail 2229 Not Specified  
    polypeptide NP_034895 RefSeq | MGI Sequence Detail 473 Not Specified  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 50
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:243662 Nawaito SA, et al., MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart. Am J Physiol Heart Circ Physiol. 2017 Jul 01;313(1):H46-H58

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory