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Mapkapk5 Gene Detail
Summary
  • Symbol
    Mapkapk5
  • Name
    MAP kinase-activated protein kinase 5
  • Synonyms
    MK5, PRAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333110
    NCBI Gene: 17165
  • Gene Overview
    MyGene.info: MAPKAPK5
Location & Maps
more
  • Sequence Map
    Chr5:121525038-121545905 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20868 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAPKAPK5, mitogen-activated protein kinase-activated protein kinase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPKAPK5, mitogen-activated protein kinase-activated protein kinase 5
    Orthology source: HomoloGene
  • Synonyms
    MAPKAP-K5, MK5, MK-5, PRAK
  • Links
    NCBI Gene ID: 8550
    neXtProt AC: NX_Q8IW41

  • Chr Location
    12q24.13; chr12:111842228-111901619 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Mapkapk5
  • Incidental Mutations
Homozygous mutant mice are viable, fertile, and show no overt abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023483 VEGA Gene Model | MGI Sequence Detail 20868 C57BL/6J ±  kb
transcript OTTMUST00000057139 VEGA | MGI Sequence Detail 2234 Not Applicable  
polypeptide OTTMUSP00000027532 VEGA | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
less
  • Protein Ontology
    PR:000010167 MAP kinase-activated protein kinase 5
Molecular
Reagents
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  • All nucleic 50
    cDNA 49
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:45995 Ni H, et al., MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase. Biochem Biophys Res Commun. 1998 Feb 13;243(2):492-6
  • Latest
    J:205386 Yoshizuka N, et al., PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res. 2012 Jun;10(6):810-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory