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Mapkapk5 Gene Detail
Summary
  • Symbol
    Mapkapk5
  • Name
    MAP kinase-activated protein kinase 5
  • Synonyms
    MK5, PRAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333110
    NCBI Gene: 17165
  • Gene Overview
    MyGene.info: MAPKAPK5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:121525038-121545905 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20868 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 61.84 cM, cytoband F
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MAPKAPK5, mitogen-activated protein kinase-activated protein kinase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPKAPK5, mitogen-activated protein kinase-activated protein kinase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAPKAP-K5, MK5, MK-5, PRAK
  • Links
    NCBI Gene ID: 8550
    neXtProt AC: NX_Q8IW41
    UniProt: Q8IW41

  • Chr Location
    12q24.12-q24.13; chr12:111842228-111902225 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile, and show no overt abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023483 VEGA Gene Model | MGI Sequence Detail 20868 C57BL/6J ±  kb
    transcript OTTMUST00000057139 VEGA | MGI Sequence Detail 2234 Not Applicable  
    polypeptide OTTMUSP00000027532 VEGA | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      51 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 49
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:243662 Nawaito SA, et al., MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart. Am J Physiol Heart Circ Physiol. 2017 Jul 01;313(1):H46-H58

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory