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Dok2
Gene Detail
 Symbol
Name
ID
Dok2
docking protein 2
MGI:1332623
Synonyms DokR, Frip, Frip
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.71 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70766036-70778495 bp, + strand
From VEGA annotation of GRCm38

  12460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dok2

Human
homologs
Human Homolog DOK2, docking protein 2, 56kDa
NCBI Gene ID 9046
neXtProt AC  NX_O60496
Human Synonyms  p56DOK, p56dok-2
Human Chr (Location)  8p21.3; chr8:21908873-21913776 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
 
Homozygous null mice display abnormal granulocyte physiology.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Dok2 interacts with 64 markers (Mir28b, Mir28c, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process MAPK cascade, positive regulation of signal transduction, ...
Component intracellular
Function insulin receptor binding, receptor signaling protein activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (16)    Images (1)
Theiler Stages: 28
Assay TypeResults
Western blot 18
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(2) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035182 (Evidence)
Ensembl Gene ModelENSMUSG00000022102 (Evidence)
Entrez Gene13449 (Evidence)
DFCITC1575469
DoTSDT.488389
NIA Mouse Gene IndexU015831
Consensus CDS ProjectCCDS27262.1
International Mouse Knockout Project StatusDok2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035182 VEGA Gene Model | MGI Sequence Detail 12460 C57BL/6J ±  kb
transcript OTTMUST00000089615 VEGA | MGI Sequence Detail 1795 Not Applicable 
polypeptide OTTMUSP00000049002 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006629 docking protein 2
References (Earliest) J:43960 Nelms K, et al., FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity. 1998 Jul;9(1):13-24
(Latest) J:209510 Hughan SC, et al., Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin alphaIIbbeta3 in mice. J Biol Chem. 2014 Feb 21;289(8):5051-60
All references(43)
Other
accession IDs
MGI:1261852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory