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Dok2
Gene Detail
Symbol

Name
ID
Dok2
docking protein 2
MGI:1332623
Synonyms
DokR, Frip, Frip
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.71 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70766036-70778495 bp, + strand
From VEGA annotation of GRCm38

  12460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Dok2
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
 
Homozygous null mice display abnormal granulocyte physiology.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Dok2 interacts with 64 markers (Mir28b, Mir28c, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process MAPK cascade, positive regulation of signal transduction, ...
Component intracellular
Function insulin receptor binding, receptor signaling protein activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (16)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 18
cDNA source data(25)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(25) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035182 (Evidence)
Ensembl Gene ModelENSMUSG00000022102 (Evidence)
Entrez Gene13449, 102637408
UniGene243323
DFCITC1575469
DoTSDT.488389
NIA Mouse Gene IndexU015831
Consensus CDS ProjectCCDS27262.1
International Mouse Knockout Project StatusDok2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035182 VEGA Gene Model | MGI Sequence Detail 12460 C57BL/6J ±  kb
transcript OTTMUST00000089615 VEGA | MGI Sequence Detail 1795 Not Applicable 
polypeptide OTTMUSP00000049002 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(38) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006629 docking protein 2
References
(Earliest) J:43960 Nelms K, et al., FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity. 1998 Jul;9(1):13-24
(Latest) J:214849 Celis-Gutierrez J, et al., Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. 2014 Sep 1;33(17):1928-40
All references(46)
Other
accession IDs
MGI:1261852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory