Dok2
Gene Detail

Symbol Name ID

Dok2 docking protein 2 MGI:1332623

Synonyms

DokR, Frip, Frip

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.71 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:70766036-70778495 bp, + strand From VEGA annotation of GRCm38   12460 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dok2

Human homologs

Human Homolog		DOK2, docking protein 2, 56kDa
NCBI Gene ID		9046
neXtProt AC		NX_O60496
Human Synonyms		p56DOK, p56dok-2
Human Chr (Location)		8p21.3; chr8:21766384-21771205 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(4) Gene trapped(9)
 

Homozygous null mice display abnormal granulocyte physiology.

 
Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	MAPK cascade, Ras protein signal transduction, ...
Function	insulin receptor binding, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (16)    Images (1)
Theiler Stages: 28

Assay Type	Results
Western blot	18

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(2) cDNA(9) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000035182 (Evidence)
Ensembl Gene Model	ENSMUSG00000022102 (Evidence)
Entrez Gene	13449 (Evidence)
DFCI	TC1575469
DoTS	DT.488389
NIA Mouse Gene Index	U015831
Consensus CDS Project	CCDS27262.1
International Mouse Knockout Project Status	Dok2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035182	VEGA Gene Model | MGI Sequence Detail	12460	C57BL/6J
transcript	OTTMUST00000089615	VEGA | MGI Sequence Detail	1795	Not Applicable
polypeptide	OTTMUSP00000049002	VEGA | MGI Sequence Detail	412	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002404	Insulin receptor substrate-1, PTB
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000006629	docking protein 2

References

(Earliest) J:43960 Nelms K, et al., FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity. 1998 Jul;9(1):13-24
(Latest) J:187941 Besin G, et al., Dok-1 overexpression promotes development of gammadelta natural killer T cells. Eur J Immunol. 2012 Sep;42(9):2491-504
All references(41)

Other accession IDs

MGI:1261852