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Dok2 Gene Detail
Summary
  • Symbol
    Dok2
  • Name
    docking protein 2
  • Synonyms
    DokR, Frip, Frip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332623
    NCBI Gene: 13449
  • Gene Overview
    MyGene.info: DOK2
Location & Maps
more
  • Sequence Map
    Chr14:70766036-70778495 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12460 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.71 cM, cytoband D2-D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DOK2, docking protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DOK2, docking protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p56DOK, p56dok-2
  • Links
    NCBI Gene ID: 9046
    neXtProt AC: NX_O60496

  • Chr Location
    8p21.3; chr8:21908873-21913743 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2957
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DOK2
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    26 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Targeted
    4
  • Genomic Mutations
    1 involving Dok2
Homozygous null mice display abnormal granulocyte physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035182 VEGA Gene Model | MGI Sequence Detail 12460 C57BL/6J ±  kb
transcript OTTMUST00000089615 VEGA | MGI Sequence Detail 1795 Not Applicable  
polypeptide OTTMUSP00000049002 VEGA | MGI Sequence Detail 412 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    71 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 9
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1261852
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:43960 Nelms K, et al., FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity. 1998 Jul;9(1):13-24
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory