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Nrf1
Gene Detail
Symbol

Name
ID
Nrf1
nuclear respiratory factor 1
MGI:1332235
Synonyms
D6Ertd415e
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:30047988-30153458 bp, + strand
From VEGA annotation of GRCm38

  105471 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NRF1
Gene Tree: Nrf1

Human
homologs
NRF1, nuclear respiratory factor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4899
neXtProt AC: NX_Q16656

Human Synonyms: ALPHA-PAL

Human Chr (Location): 7q32; chr7:129611702-129757082 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(120) : Gene trapped(117) Targeted(3)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit early embryonic lethality between E3.5 and E6.5 associated with decreased cellular proliferation and mitochondrial DNA content.
 
Interactions
Nrf1 interacts with 332 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (11 records)
Data Summary: Results (127)    Tissues (40)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 116
Northern blot 6
RT-PCR 5
cDNA source data(89)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NRF1 ; Xenbase nrf1 ; ZFIN nrf1    NEW 
Molecular
reagents
All nucleic(92) cDNA(89) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000014351 (Evidence)
Ensembl Gene Model ENSMUSG00000058440 (Evidence)
Entrez Gene 18181 (Evidence)
UniGene 259258
DFCI TC1586794, TC1578429, TC1638633, TC1621642, TC1671970, TC1716804
DoTS DT.94193429, DT.91281188, DT.527185, DT.40162121, DT.101407343
NIA Mouse Gene Index U006624
Consensus CDS Project CCDS19968.1, CCDS51739.1, CCDS51740.1, CCDS51741.1, CCDS51742.1
International Mouse Phenotyping Consortium Status Nrf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014351 VEGA Gene Model | MGI Sequence Detail 105471 C57BL/6J ±  kb
transcript OTTMUST00000033918 VEGA | MGI Sequence Detail 1879 Not Applicable 
polypeptide OTTMUSP00000015188 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(142) RefSeq(28) UniProt(14)
Polymorphisms
SNPs within 2kb(619 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012675 Beta-grasp domain
InterPro IPR013029 Domain of unknown function DUF933
InterPro IPR019526 Nuclear respiratory factor-1, activation binding domain
InterPro IPR019525 Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain
InterPro IPR012676 TGS-like
Protein Ontology PR:000011422 nuclear respiratory factor 1
References
(Earliest) J:56445 Huo L, et al., Multiple 5'-untranslated exons in the nuclear respiratory factor 1 gene span 47 kb and contribute to transcript heterogeneity and translational efficiency. Gene. 1999 Jun 11;233(1-2):213-24
(Latest) J:198125 Rajakumari S, et al., EBF2 determines and maintains brown adipocyte identity. Cell Metab. 2013 Apr 2;17(4):562-74
All references(57)
Other
accession IDs
MGI:1196416, MGI:2141782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory