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Nrf1 Gene Detail
Summary
  • Symbol
    Nrf1
  • Name
    nuclear respiratory factor 1
  • Synonyms
    D6Ertd415e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332235
    NCBI Gene: 18181
Location & Maps
more
  • Sequence Map
    Chr6:30047988-30153458 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      105471 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NRF1, nuclear respiratory factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NRF1, nuclear respiratory factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALPHA-PAL
  • Links
    NCBI Gene ID: 4899
    neXtProt AC: NX_Q16656

  • Chr Location
    7q32; chr7:129611702-129757082 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3674
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NRF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    120
  • Gene trapped
    117
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit early embryonic lethality between E3.5 and E6.5 associated with decreased cellular proliferation and mitochondrial DNA content.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014351 VEGA Gene Model | MGI Sequence Detail 105471 C57BL/6J ±  kb
transcript OTTMUST00000033918 VEGA | MGI Sequence Detail 1879 Not Applicable  
polypeptide OTTMUSP00000015188 VEGA | MGI Sequence Detail 534 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    619 from dbSNP Build 137
Protein
Information
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  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000011422 nuclear respiratory factor 1
  • InterPro Domains
    IPR012675 Beta-grasp domain
    IPR013029 Domain of unknown function DUF933
    IPR019526 Nuclear respiratory factor-1, activation binding domain
    IPR019525 Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain
    IPR012676 TGS-like
Molecular
Reagents
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  • All nucleic 92
    cDNA 89
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1196416, MGI:2141782
References
more
  • Summaries
    All 55
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:56445 Huo L, et al., Multiple 5'-untranslated exons in the nuclear respiratory factor 1 gene span 47 kb and contribute to transcript heterogeneity and translational efficiency. Gene. 1999 Jun 11;233(1-2):213-24
  • Latest
    J:227360 Chen J, et al., Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status. FEBS Lett. 2015 Aug 19;589(18):2347-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory