Nrf1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nrf1
nuclear respiratory factor 1
MGI:1332235

24 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nrf1^{tm1c(KOMP)Wtsi}/Nrf1^{tm1c(KOMP)Wtsi} Tg(Rho-icre)1Ck/0 involves: C57BL/6N * SJL	abnormal cone electrophysiology	J:267504
	abnormal mitochondrial morphology	J:267504
	abnormal mitochondrial physiology	J:267504
	abnormal rod electrophysiology	J:267504
	decreased mitochondrial size	J:267504
	decreased retina cone cell number	J:267504
	decreased retina rod cell number	J:267504
	increased mitochondrial number	J:267504
	retina rod cell degeneration	J:267504
	short photoreceptor inner segment	J:267504
	short photoreceptor outer segment	J:267504
	thin retina outer nuclear layer	J:267504
Nrf1^{tm1c(KOMP)Wtsi}/Nrf1^{tm1c(KOMP)Wtsi} Tg(Six3-cre)69Frty/0 involves: C57BL/6N * DBA/2	abnormal axon extension	J:267504
	abnormal retina layer morphology	J:267504
	abnormal retina morphology	J:267504
	abnormal retina neuronal layer morphology	J:267504
	abnormal retina progenitor cell morphology	J:267504
	absent retina ganglion layer	J:267504
	decreased retina ganglion cell number	J:267504
	decreased total retina thickness	J:267504
	retina hypoplasia	J:267504
	thin retina ganglion layer	J:267504
Nrf1^tm1Rcs/Nrf1^tm1Rcs involves: 129X1/SvJ	abnormal mitochondrial morphology	J:67376
	decreased cell proliferation	J:67376
	embryonic lethality between implantation and somite formation, complete penetrance	J:67376

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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