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Dclk1 Gene Detail
Summary
  • Symbol
    Dclk1
  • Name
    doublecortin-like kinase 1
  • Synonyms
    1700113D08Rik, 2810480F11Rik, Click-I, CPG16, Dcamkl1, Dcl, DCLK, mKIAA0369
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330861
    NCBI Gene: 13175
  • Gene Overview
    MyGene.info: DCLK1
Location & Maps
more
  • Sequence Map
    Chr3:55242364-55539068 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      296705 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 26.53 cM, cytoband D
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DCLK1, doublecortin like kinase 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    DCLK1, doublecortin like kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
  • Links
    NCBI Gene ID: 9201
    neXtProt AC: NX_O15075

  • Chr Location
    13q13; chr13:35768652-36132020 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    36 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    3
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    2 involving Dclk1
  • Incidental Mutations
Mice homozygous for a null allele lack the corpus callosum and hippocampal commissure and show aberrant interhemispheric axonal projections. Mice homozygous for a different null allele have normal gross brain architecture but show axonal and dendritic defects following knockdown of Dcx expression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053093 VEGA Gene Model | MGI Sequence Detail 296705 C57BL/6J ±  kb
transcript OTTMUST00000132774 VEGA | MGI Sequence Detail 7962 Not Applicable  
polypeptide OTTMUSP00000070744 VEGA | MGI Sequence Detail 739 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2331 from dbSNP Build 142
Protein
Information
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  • UniProt
    19 Sequences
  • EC
  • InterPro Domains
    IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
    IPR003533 Doublecortin domain
    IPR017302 Neuronal migration protein doublecortin, chordata
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 30
    cDNA 27
    Primer pair 1
    Other 2

    Microarray probesets 14
Other
Accession IDs
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MGI:1914611, MGI:1920056, MGI:2139800
References
more
  • Summaries
    All 62
    Developmental Gene Expression 23
    Gene Ontology 6
    Phenotypes 22
  • Earliest
    J:49947 Omori Y, et al., Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. J Hum Genet. 1998;43(3):169-77
  • Latest
    J:228749 Nawabi H, et al., Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18;88(4):704-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory