Dclk1 MGI Mouse Gene Detail - MGI:1330861 - doublecortin-like kinase 1

Symbol

Dclk1
Name

doublecortin-like kinase 1
Synonyms

1700113D08Rik, 2810480F11Rik, Click-I, CPG16, Dcamkl1, Dcl, DCLK, mKIAA0369

Feature Type

protein coding gene
IDs

MGI:1330861
NCBI Gene: 13175
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr3:55149785-55446489 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 26.53 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

8232 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330861	protein coding gene	Chr3:55149724-55446489 (+)
129S1/SvImJ	ENSMUSG00200022873	protein coding gene	Chr3:52007230-52007642 (+)
129S1/SvImJ	ENSMUSGG00200054573	protein coding gene	Chr3:52221903-52299244 (+)
A/J	ENSMUSGG00195055096	protein coding gene	Chr3:52158553-52235916 (+)
A/J	ENSMUSG00195031669	protein coding gene	Chr3:51943874-51944286 (+)
AKR/J	ENSMUSG00220026724	protein coding gene	Chr3:52011814-52012226 (+)
AKR/J	ENSMUSGG00220054679	protein coding gene	Chr3:52231712-52308626 (+)
BALB/cJ	ENSMUSG00180024233	protein coding gene	Chr3:52023152-52023564 (+)
BALB/cJ	ENSMUSGG00180055380	protein coding gene	Chr3:52237852-52315181 (+)
C3H/HeJ	ENSMUSGG00175054907	protein coding gene	Chr3:52079469-52156805 (+)
C3H/HeJ	ENSMUSG00175008287	protein coding gene	Chr3:51864785-51865197 (+)
C57BL/6NJ	ENSMUSG00215005695	protein coding gene	Chr3:52301876-52302288 (+)
C57BL/6NJ	ENSMUSGG00215055549	protein coding gene	Chr3:52516557-52593903 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025001	protein coding gene	Chr3:48821062-49117877 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210054894	protein coding gene	Chr3:52200857-52278203 (+)
CBA/J	ENSMUSG00210003229	protein coding gene	Chr3:51986202-51986614 (+)
DBA/2J	ENSMUSGG00185057329	protein coding gene	Chr3:52409597-52486506 (+)
DBA/2J	ENSMUSG00185027787	protein coding gene	Chr3:52192796-52193208 (+)
FVB/NJ	ENSMUSGG00205054397	protein coding gene	Chr3:51393678-51470606 (+)
FVB/NJ	ENSMUSG00205008678	protein coding gene	Chr3:51176730-51177142 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055292	protein coding gene	Chr3:54376476-54453808 (+)
LP/J	ENSMUSG00230002943	protein coding gene	Chr3:54161824-54162236 (+)
NOD/ShiLtJ	ENSMUSGG00190054549	protein coding gene	Chr3:52579466-52656381 (+)
NOD/ShiLtJ	ENSMUSG00190026586	protein coding gene	Chr3:52359604-52360016 (+)
NZO/HlLtJ	ENSMUSG00225016551	protein coding gene	Chr3:56774213-56774625 (+)
NZO/HlLtJ	ENSMUSGG00225055487	protein coding gene	Chr3:56988866-57066201 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010006908	protein coding gene	Chr3:52509216-52803281 (+)
WSB/EiJ	no annotation

Human Ortholog

DCLK1, doublecortin like kinase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCLK1, doublecortin like kinase 1
Synonyms

CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
Links

HGNC:2700

NCBI Gene ID: 9201

UniProt: O15075
Chr Location

13q13.3; chr13:35768652-36132164 (-) GRCh38

MGI Vertebrate Homology

Dclk1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DCLK1
Protein SuperFamily

Doublin
Gene Tree

Dclk1

less

References

1 with disease annotations

less

Phenotype Summary

11 phenotypes from 4 alleles in 4 genetic backgrounds
37 phenotypes from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

11
Gene trapped

2
Radiation induced

2
Targeted

7
Genomic Mutations

2 involving Dclk1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele lack the corpus callosum and hippocampal commissure and show aberrant interhemispheric axonal projections. Mice homozygous for a different null allele have normal gross brain architecture but show axonal and dendritic defects following knockdown of Dcx expression.

less

All GO Annotations

33
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1138
Tissues

204
cDNA Data

25
Literature Summary

40

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DCLK1

Xenbase dclk1

ZFIN dclk1a

less

All Sequences

165
RefSeq

44
UniProt

23
CCDS

CCDS17359.1, CCDS50909.1, CCDS50910.1, CCDS79908.1, CCDS79909.1, CCDS89626.1, CCDS89627.1

Ensembl

ENSMUSG00000027797 (Evidence)
NCBI Gene

13175

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027797	Ensembl Gene Model \| MGI Sequence Detail	296705	C57BL/6J	± kb
transcript	ENSMUST00000054237	Ensembl \| MGI Sequence Detail	7847	Not Applicable
polypeptide	ENSMUSP00000050034	Ensembl \| MGI Sequence Detail	756	Not Applicable

less

UniProt

23 Sequences
EC

2.7.11.1
InterPro Domains

IPR003533 Doublecortin domain

IPR036572 Doublecortin domain superfamily

IPR017302 Neuronal migration protein doublecortin, chordates

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q9JLM8 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

less

All nucleic 56

cDNA 36

Primer pair 14

Other 6

Antibodies 10

Microarray probesets 14

less

MGI:1914611, MGI:1920056, MGI:2139800

Summaries

All 138

Developmental Gene Expression 40

Diseases 1

Gene Ontology 11

Phenotypes 42
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:387192 Shen Y, et al., A progenitor cell population contributes to prenatal injury repair and neonatal antimicrobial defense in the small intestine. Cell Rep. 2026 Jun 4;45(6):117503

TSS for Dclk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29154	Chr3:55149951-55149976 (+)	179 bp
Tssr29155	Chr3:55149982-55150000 (+)	206 bp
Tssr29156	Chr3:55150007-55150066 (+)	252 bp
Tssr29157	Chr3:55150074-55150085 (+)	295 bp
Tssr29158	Chr3:55154486-55154505 (+)	4,711 bp
Tssr29159	Chr3:55154524-55154571 (+)	4,763 bp
Tssr29160	Chr3:55188670-55188687 (+)	38,894 bp
Tssr29161	Chr3:55231809-55231812 (+)	82,026 bp
Tssr29162	Chr3:55279406-55279430 (+)	129,633 bp
Tssr29163	Chr3:55369279-55369284 (+)	219,497 bp
Tssr29164	Chr3:55369288-55369382 (+)	219,550 bp
Tssr29165	Chr3:55369384-55369398 (+)	219,606 bp
Tssr29166	Chr3:55374614-55374618 (+)	224,831 bp
Tssr29167	Chr3:55410573-55410574 (+)	260,789 bp
Tssr29168	Chr3:55435296-55435307 (+)	285,517 bp
Tssr29169	Chr3:55441199-55441216 (+)	291,423 bp
Tssr29170	Chr3:55441413-55441416 (+)	291,630 bp
Tssr29171	Chr3:55444597-55444606 (+)	294,817 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24