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Dclk1
Gene Detail
 Symbol
Name
ID
Dclk1
doublecortin-like kinase 1
MGI:1330861
Synonyms 1700113D08Rik, 2810480F11Rik, Click-I, CPG16, Dcamkl1, Dcl, DCLK, mKIAA0369
Feature Type protein coding gene
Genetic Map
Chromosome 3
26.53 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:55242526-55539064 bp, + strand
From Ensembl annotation of GRCm38

  296539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130530  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 dog; 1 chicken

Protein SuperFamily: neuronal migration protein doublecortin
Gene Tree: Dclk1

Human
homologs
Human Homolog DCLK1, doublecortin-like kinase 1
NCBI Gene ID 9201
neXtProt AC  NX_O15075
Human Synonyms  CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
Human Chr (Location)  13q13; chr13:35768652-36132020 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele lack the corpus callosum and hippocampal commissure and show aberrant interhemispheric axonal projections. Mice homozygous for a different null allele have normal gross brain architecture but show axonal and dendritic defects following knockdown of Dcx expression.
 
Interactions
Dclk1 interacts with 483 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process axon extension, axonogenesis, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (203)    Tissues (111)    Images (64)
Theiler Stages: 10, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
Immunohistochemistry 57
RNA in situ 116
Northern blot 28
RT-PCR 2
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(27) Primer pair(1) Other(2)
Microarray probesets(14)
Other database
links
Ensembl Gene ModelENSMUSG00000027797 (Evidence)
Entrez Gene13175 (Evidence)
DFCITC1574274, TC1576854, TC1592013, TC1594392, TC1595323, TC1601839, TC1602153, TC1608074, TC1618212, TC1625979, TC1637390, TC1656600, TC1682037, TC1765509
DoTSDT.101286893, DT.101385023, DT.101738898, DT.101738899, DT.40145810, DT.526876, DT.55118768, DT.55196432, DT.91318315, DT.91354133, DT.91424544, DT.91437067, DT.94181353, DT.94181355, DT.94181371
NIA Mouse Gene IndexU042427, U379575
EC2.7.11.1
Consensus CDS ProjectCCDS17359.1, CCDS50909.1, CCDS50910.1
International Mouse Knockout Project StatusDclk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027797 Ensembl Gene Model | MGI Sequence Detail 296539 C57BL/6J ±  kb
transcript ENSMUST00000054237 Ensembl | MGI Sequence Detail 7847 Not Applicable 
polypeptide ENSMUSP00000050034 Ensembl | MGI Sequence Detail 756 Not Applicable 

For the selected sequences
All sequences(120) RefSeq(26) UniProt(14)
Polymorphisms SNPs within 2kb(2340 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR003533 Doublecortin domain
InterPro IPR017302 Neuronal migration protein doublecortin, chordata
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000006310 serine/threonine-protein kinase DCLK1
References (Earliest) J:49947 Omori Y, et al., Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. J Hum Genet. 1998;43(3):169-77
(Latest) J:206760 May R, et al., Brief report: dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury. Stem Cells. 2014 Mar;32(3):822-7
All references(62)
Other
accession IDs
MGI:1914611, MGI:1920056, MGI:2139800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory