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Atp8a1
Gene Detail
Symbol

Name
ID
Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
MGI:1330848
Synonyms
Atp3a2, B230107D19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
36.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:67618140-67847432 bp, - strand
From VEGA annotation of GRCm38

  229293 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ATP8A1
Gene Tree: Atp8a1

Human
homologs
ATP8A1, ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10396
neXtProt AC: NX_Q9Y2Q0

Human Synonyms: ATPASEII, ATPIA, ATPP2

Human Chr (Location): 4p13; chr4:42408373-42657105 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Radiation induced(1) Targeted(2)
Genomic Mutations involving Atp8a1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice are viable, fertile and phenotypically normal.
 
Phenotype Images(4)
Interactions
Atp8a1 interacts with 375 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process learning, lipid transport, ...
Component cytoplasmic vesicle, endoplasmic reticulum, ...
Function ATP binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (405)    Tissues (243)    Images (97)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 288
In situ reporter (knock in) 78
RT-PCR 39
cDNA source data(121)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp8a1    NEW 
Molecular
reagents
All nucleic(124) cDNA(121) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000022523 (Evidence)
Ensembl Gene Model ENSMUSG00000037685 (Evidence)
Entrez Gene 11980 (Evidence)
UniGene 153230
DFCI TC1597246, TC1634945, TC1636115, TC1589797, TC1579931, TC1705608, TC1661323
DoTS DT.91577040, DT.94275708, DT.101736975, DT.91314345, DT.101382278
EC 3.6.3.1
Consensus CDS Project CCDS39104.1, CCDS39105.1
International Mouse Phenotyping Consortium Status Atp8a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022523 VEGA Gene Model | MGI Sequence Detail 229293 C57BL/6J ±  kb
transcript OTTMUST00000053945 VEGA | MGI Sequence Detail 8176 Not Applicable 
polypeptide OTTMUSP00000025685 VEGA | MGI Sequence Detail 1164 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(28) UniProt(11)
Polymorphisms
SNPs within 2kb(1452 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1456)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR023214 HAD-like domain
InterPro IPR006539 Phospholipid-transporting P-type ATPase, subfamily IV
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
Protein Ontology PR:000029290 phospholipid-transporting ATPase IA
References
(Earliest) J:47134 Halleck MS, et al., Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Genome Res. 1998 Apr;8(4):354-61
(Latest) J:197107 Kato U, et al., Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J Biol Chem. 2013 Feb 15;288(7):4922-34
All references(43)
Other
accession IDs
MGI:2140919, MGI:2141001, MGI:2141248, MGI:2141251, MGI:2444604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory