Atp8a1
Gene Detail

Symbol Name ID

Atp8a1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 MGI:1330848

Synonyms

Atp3a2, B230107D19Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 5

36.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:67618140-67847432 bp, - strand From VEGA annotation of GRCm38   229293 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Atp8a1 ± 2 cM)

Gene Tree: Atp8a1

Human ortholog

ATP8A1 ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1 NCBI Gene ID 10396
Human Synonyms: ATPASEII, ATPIA, ATPP2
Human Chr4:42410390-42659122 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygous mutant mice are viable, fertile and phenotypically normal.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cation transport, phospholipid transport
Component	cytoplasmic vesicle, endoplasmic reticulum, ...
Function	ATP binding, cation-transporting ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (405)    Tissues (244)    Images (97)
Theiler Stages: 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	288
In situ reporter (knock in)	78
RT-PCR	39

cDNA source data(120)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(123) cDNA(120) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000022523 (Evidence)
Ensembl Gene Model	ENSMUSG00000037685 (Evidence)
Entrez Gene	11980 (Evidence)
UniGene	153230
DFCI	TC1579931, TC1589797, TC1597246, TC1634945, TC1636115, TC1661323, TC1705608
DoTS	DT.101382278, DT.101736975, DT.91314345, DT.91577040, DT.94275708
EC	3.6.3.1
Consensus CDS Project	CCDS39104.1, CCDS39105.1
International Mouse Knockout Project Status	Atp8a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022523	VEGA Gene Model | MGI Sequence Detail	229293	C57BL/6J
transcript	OTTMUST00000053945	VEGA | MGI Sequence Detail	8176	Not Applicable
polypeptide	OTTMUSP00000025685	VEGA | MGI Sequence Detail	1164	Not Applicable

All sequences(94) RefSeq(4) UniProt(12)

Polymorphisms

SNPs(1287 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR006539	ATPase, P-type, phospholipid-translocating, flippase
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023214	HAD-like domain

References

(Earliest) J:47134 Halleck MS, et al., Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Genome Res. 1998 Apr;8(4):354-61
(Latest) J:179412 Levano K, et al., Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning. J Neurochem. 2012 Jan;120(2):302-313
All references(43)

Other accession IDs

MGI:2140919, MGI:2141001, MGI:2141248, MGI:2141251, MGI:2444604