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Csrp3 Gene Detail
Summary
  • Symbol
    Csrp3
  • Name
    cysteine and glycine-rich protein 3
  • Synonyms
    CRP3, MLP, muscle LIM protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330824
    NCBI Gene: 13009
  • Gene Overview
    MyGene.info: CSRP3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:48830398-48848033 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 31.11 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330824
protein coding gene Chr7:48830398-48848051 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032295
protein coding gene Chr7:49435526-49453167 (-)
A/J MGP_AJ_G0032274
protein coding gene Chr7:48741654-48759269 (-)
AKR/J MGP_AKRJ_G0032210
protein coding gene Chr7:49885508-49903141 (-)
BALB/cJ MGP_BALBcJ_G0032286
protein coding gene Chr7:48389748-48407391 (-)
C3H/HeJ MGP_C3HHeJ_G0031999
protein coding gene Chr7:50259648-50277269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032779
protein coding gene Chr7:51742048-51759715 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029785
protein coding gene Chr7:51917241-51935243 (-)
CAST/EiJ MGP_CASTEiJ_G0031327
protein coding gene Chr7:41640900-41658652 (-)
CBA/J MGP_CBAJ_G0031964
protein coding gene Chr7:53478432-53496059 (-)
DBA/2J MGP_DBA2J_G0032121
protein coding gene Chr7:47951828-47969491 (-)
FVB/NJ MGP_FVBNJ_G0032075
protein coding gene Chr7:47878695-47896322 (-)
LP/J MGP_LPJ_G0032202
protein coding gene Chr7:50398382-50417438 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032112
protein coding gene Chr7:52601839-52619464 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032796
protein coding gene Chr7:48865204-48882859 (-)
PWK/PhJ MGP_PWKPhJ_G0031047
protein coding gene Chr7:41287320-41305315 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030888
protein coding gene Chr7:37035930-37054942 (-)
WSB/EiJ MGP_WSBEiJ_G0031445
protein coding gene Chr7:49521172-49538818 (-)



Homology
more
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLP, CMD1M, CMH12, CRP3, LMO4, MLP
  • Links
    NCBI Gene ID: 8048
    neXtProt AC: NX_P50461
    UniProt: P50461

  • Chr Location
    11p15.1; chr11:19182030-19210571 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20742
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CSRP3
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Csrp3 mouse models; 2 with human CSRP3 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit dilated cardiomyopathy characterized by disrupted cardiomyocyte organization that results in premature death, left ventricle dilation, hypertrophy, decreased contractility, and fibrosis. Some homozygotes die postnataly due to heart failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030470 Ensembl Gene Model | MGI Sequence Detail 17636 C57BL/6J ±  kb
    transcript ENSMUST00000167786 Ensembl | MGI Sequence Detail 899 Not Applicable  
    polypeptide ENSMUSP00000129378 Ensembl | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 15
      Diseases 3
      Gene Ontology 9
      Phenotypes 40
    • Earliest
      J:33993 Harrod GV, et al., Murine MLP: cloning and expression in the embryonic head. J Craniofac Genet Dev Biol. 1996 Apr-Jun;16(2):65-73
    • Latest
      J:265952 Hernandez-Carretero A, et al., Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E267-E278

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory