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Csrp3
Gene Detail
 Symbol
Name
ID
Csrp3
cysteine and glycine-rich protein 3
MGI:1330824
Synonyms CRP3, MLP, muscle LIM protein
Feature Type protein coding gene
Genetic Map
Chromosome 7
31.11 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:48830398-48848051 bp, - strand
From NCBI annotation of GRCm38

  17654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Csrp3

Human
homologs
Human Homolog CSRP3, cysteine and glycine-rich protein 3 (cardiac LIM protein)
NCBI Gene ID 8048
neXtProt AC  NX_P50461
Human Synonyms  CLP, CMD1M, CMH12, CRP3, LMO4, MLP
Human Chr (Location)  11p15.1; chr11:19182030-19210571 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CSRP3
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit dilated cardiomyopathy characterized by disrupted cardiomyocyte organization that results in premature death, left ventricle dilation, hypertrophy, decreased contractility, and fibrosis. Some homozygotes die postnataly due to heart failure.
 
Human Diseases Modeled Using Mouse Csrp3 (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Csrp3 interacts with 40 markers (Mir22, Mir93, Mir127, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cardiac muscle contraction, cardiac muscle hypertrophy, ...
Component cell, cytoplasm, ...
Function actinin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (196)    Tissues (49)    Images (29)
Theiler Stages: 15, 17, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 192
Northern blot 2
RT-PCR 2
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030470 (Evidence)
Entrez Gene13009 (Evidence)
DFCITC1577355
DoTSDT.101174300, DT.533353, DT.55126999, DT.94346970
NIA Mouse Gene IndexU028593
Consensus CDS ProjectCCDS21305.1
International Mouse Knockout Project StatusCsrp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13009 NCBI Gene Model | MGI Sequence Detail 17654 C57BL/6J ±  kb
transcript NM_013808 RefSeq | MGI Sequence Detail 1057 C57BL/6 
polypeptide P50462 UniProt | EBI | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000005961 cysteine and glycine-rich protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:33993 Harrod GV, et al., Murine MLP: cloning and expression in the embryonic head. J Craniofac Genet Dev Biol. 1996 Apr-Jun;16(2):65-73
(Latest) J:187969 Pazin DE, et al., Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012 Nov;241(11):1816-26
All references(73)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory