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Csrp3 Gene Detail
Summary
  • Symbol
    Csrp3
  • Name
    cysteine and glycine-rich protein 3
  • Synonyms
    CRP3, MLP, muscle LIM protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330824
    NCBI Gene: 13009
  • Gene Overview
    MyGene.info: CSRP3
Location & Maps
more
  • Sequence Map
    Chr7:48830398-48848033 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17636 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 31.11 cM, cytoband B3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLP, CMD1M, CMH12, CRP3, LMO4, MLP
  • Links
    NCBI Gene ID: 8048
    neXtProt AC: NX_P50461

  • Chr Location
    11p15.1; chr11:19182030-19210571 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20742
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CSRP3
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Csrp3 mouse models; 2 with human CSRP3 associations

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 1M; CMD1M   OMIM: 607482 View 1 model
Cardiomyopathy, Familial Hypertrophic, 12; CMH12   OMIM: 612124 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit dilated cardiomyopathy characterized by disrupted cardiomyocyte organization that results in premature death, left ventricle dilation, hypertrophy, decreased contractility, and fibrosis. Some homozygotes die postnataly due to heart failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058985 VEGA Gene Model | MGI Sequence Detail 17636 C57BL/6J ±  kb
transcript OTTMUST00000144728 VEGA | MGI Sequence Detail 899 Not Applicable  
polypeptide OTTMUSP00000075412 VEGA | MGI Sequence Detail 194 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    211 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005961 cysteine and glycine-rich protein 3
  • InterPro Domains
    IPR001781 Zinc finger, LIM-type
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 9
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 73
    Developmental Gene Expression 13
    Diseases 3
    Gene Ontology 10
    Phenotypes 32
  • Earliest
    J:33993 Harrod GV, et al., Murine MLP: cloning and expression in the embryonic head. J Craniofac Genet Dev Biol. 1996 Apr-Jun;16(2):65-73
  • Latest
    J:216415 Dwyer J, et al., The formin FHOD1 in cardiomyocytes. Anat Rec (Hoboken). 2014 Sep;297(9):1560-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory