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Csrp3
Gene Detail
Symbol

Name
ID
Csrp3
cysteine and glycine-rich protein 3
MGI:1330824
Synonyms
CRP3, MLP, muscle LIM protein
Feature Type
protein coding gene
Genetic Map
Chromosome 7
31.11 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:48830398-48848051 bp, - strand
From NCBI annotation of GRCm38

  17654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSRP3
Gene Tree: Csrp3

Human
homologs
CSRP3, cysteine and glycine-rich protein 3 (cardiac LIM protein)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8048
neXtProt AC: NX_P50461

Human Synonyms: CLP, CMD1M, CMH12, CRP3, LMO4, MLP

Human Chr (Location): 11p15.1; chr11:19182030-19210571 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CSRP3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit dilated cardiomyopathy characterized by disrupted cardiomyocyte organization that results in premature death, left ventricle dilation, hypertrophy, decreased contractility, and fibrosis. Some homozygotes die postnataly due to heart failure.
 
Human Diseases Modeled in Mice Using Csrp3 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Csrp3 interacts with 40 markers (Mir22, Mir93, Mir127, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process cardiac muscle contraction, cardiac muscle hypertrophy, ...
Component cell, cytoplasm, ...
Function actinin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (196)    Tissues (49)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 192
Northern blot 2
RT-PCR 2
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CSRP3 ; Xenbase csrp3 ; ZFIN csrp3    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030470 (Evidence)
Entrez Gene 13009 (Evidence)
DFCI TC1577355
DoTS DT.94346970, DT.55126999, DT.533353, DT.101174300
NIA Mouse Gene Index U028593
Consensus CDS Project CCDS21305.1
International Mouse Phenotyping Consortium Status Csrp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13009 NCBI Gene Model | MGI Sequence Detail 17654 C57BL/6J ±  kb
transcript NM_013808 RefSeq | MGI Sequence Detail 1057 C57BL/6 
polypeptide P50462 UniProt | EBI | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000005961 cysteine and glycine-rich protein 3
Graphical View of Protein Domain Structure
References
(Earliest) J:33993 Harrod GV, et al., Murine MLP: cloning and expression in the embryonic head. J Craniofac Genet Dev Biol. 1996 Apr-Jun;16(2):65-73
(Latest) J:216415 Dwyer J, et al., The formin FHOD1 in cardiomyocytes. Anat Rec (Hoboken). 2014 Sep;297(9):1560-70
All references(73)
Disease annotation references (3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory