Acox1
Gene Detail

Symbol Name ID

Acox1 acyl-Coenzyme A oxidase 1, palmitoyl MGI:1330812

Synonyms

Acyl-CoA oxidase, AOX, D130055E20Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

80.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:116171888-116199045 bp, - strand From VEGA annotation of GRCm38   27158 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: acyl-CoA oxidase
Gene Tree: Acox1

Human homologs

Human Homolog		ACOX1, acyl-CoA oxidase 1, palmitoyl
NCBI Gene ID		51
neXtProt AC		NX_Q15067
Human Synonyms		ACOX, PALMCOX, SCOX
Human Chr (Location)		17q25.1; chr17:73937588-73975515 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ACOX1

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(2) Chemically induced(1)
 

Mice homozygous for a targeted mutation that inactivates the gene show growth retardation, infertility, excess very long chain fatty acids in the blood, and progressive liver disease, including hepatomegaly, and hepatic adenomas and carcinomas.

 
Human Diseases Modeled Using Mouse Acox1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(7)

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, ...
Component	cytoplasm, mitochondrion, ...
Function	acyl-CoA dehydrogenase activity, acyl-CoA oxidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (263)    Tissues (130)    Images (39)
Theiler Stages: 15, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	166
Northern blot	59
Western blot	23
RT-PCR	15

cDNA source data(258)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(268) cDNA(264) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000003754 (Evidence)
Ensembl Gene Model	ENSMUSG00000020777 (Evidence)
Entrez Gene	11430 (Evidence)
UniGene	356689
DFCI	TC1572314, TC1583948
DoTS	DT.101266055, DT.101374584, DT.94303614, DT.94377781
NIA Mouse Gene Index	U033646
EC	1.3.3.6
Consensus CDS Project	CCDS25660.1
International Mouse Knockout Project Status	Acox1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003754	VEGA Gene Model | MGI Sequence Detail	27158	C57BL/6J
transcript	OTTMUST00000008212	VEGA | MGI Sequence Detail	3987	Not Applicable
polypeptide	OTTMUSP00000003995	VEGA | MGI Sequence Detail	661	Not Applicable

All sequences(49) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009100	Acyl-CoA dehydrogenase/oxidase
InterPro	IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro	IPR012258	Acyl-CoA oxidase
InterPro	IPR002655	Acyl-CoA oxidase, C-terminal
InterPro	IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology	PR:000003642	peroxisomal acyl-coenzyme A oxidase 1

References

(Earliest) J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
(Latest) J:192378 Baarine M, et al., Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins. Neuroscience. 2012 Jun 28;213:1-18
All references(73)

Other accession IDs

MGI:2141377, MGI:2441945