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Acox1
Gene Detail
Symbol

Name
ID
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
MGI:1330812
Synonyms
Acyl-CoA oxidase, AOX, D130055E20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:116171888-116199045 bp, - strand
From VEGA annotation of GRCm38

  27158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: acyl-CoA oxidase
Gene Tree: Acox1

Human
homologs
Human Homolog ACOX1, acyl-CoA oxidase 1, palmitoyl
NCBI Gene ID 51
neXtProt AC  NX_Q15067
Human Synonyms  ACOX, PALMCOX, SCOX
Human Chr (Location)  17q25.1; chr17:75941507-75979434 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACOX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation that inactivates the gene show growth retardation, infertility, excess very long chain fatty acids in the blood, and progressive liver disease, including hepatomegaly, and hepatic adenomas and carcinomas.
 
Human Diseases Modeled Using Mouse Acox1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(7)
Interactions
Acox1 interacts with 222 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, ...
Component cytoplasm, membrane, ...
Function acyl-CoA dehydrogenase activity, acyl-CoA oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (302)    Tissues (171)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 205
Northern blot 59
Western blot 23
RT-PCR 15
cDNA source data(259)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(269) cDNA(265) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003754 (Evidence)
Ensembl Gene ModelENSMUSG00000020777 (Evidence)
Entrez Gene11430 (Evidence)
UniGene356689
DFCITC1572314, TC1583948
DoTSDT.101266055, DT.101374584, DT.94303614, DT.94377781
NIA Mouse Gene IndexU033646
EC1.3.3.6
Consensus CDS ProjectCCDS25660.1, CCDS70354.1
International Mouse Knockout Project StatusAcox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003754 VEGA Gene Model | MGI Sequence Detail 27158 C57BL/6J ±  kb
transcript OTTMUST00000008212 VEGA | MGI Sequence Detail 3987 Not Applicable 
polypeptide OTTMUSP00000003995 VEGA | MGI Sequence Detail 661 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(193 from dbSNP Build 137)    SNPs within 2kb including multiple locations(199)
Protein-related
information
ResourceIDDescription
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR012258 Acyl-CoA oxidase
InterPro IPR002655 Acyl-CoA oxidase, C-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003642 peroxisomal acyl-coenzyme A oxidase 1
References
(Earliest) J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
(Latest) J:195239 Ahmed SM, et al., KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J Cell Biol. 2012 Dec 10;199(6):951-67
All references(75)
Disease annotation references (1)
Other
accession IDs
MGI:2141377, MGI:2441945

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory