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Acox1
Gene Detail
Symbol

Name
ID
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
MGI:1330812
Synonyms
Acyl-CoA oxidase, AOX, D130055E20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:116171888-116199045 bp, - strand
From VEGA annotation of GRCm38

  27158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACOX1
Protein SuperFamily: acyl-CoA oxidase
Gene Tree: Acox1

Human
homologs
ACOX1, acyl-CoA oxidase 1, palmitoyl
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51
neXtProt AC: NX_Q15067

Human Synonyms: ACOX, PALMCOX, SCOX

Human Chr (Location): 17q25.1; chr17:75941507-75979434 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ACOX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation that inactivates the gene show growth retardation, infertility, excess very long chain fatty acids in the blood, and progressive liver disease, including hepatomegaly, and hepatic adenomas and carcinomas.
 
Human Diseases Modeled in Mice Using Acox1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(7)
Interactions
Acox1 interacts with 222 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (18 records)
Data Summary: Results (302)    Tissues (171)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 205
Northern blot 59
Western blot 23
RT-PCR 15
cDNA source data(259)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acox1 ; ZFIN acox1    NEW 
Molecular
reagents
All nucleic(269) cDNA(265) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000003754 (Evidence)
Ensembl Gene Model ENSMUSG00000020777 (Evidence)
Entrez Gene 11430 (Evidence)
UniGene 356689
DFCI TC1583948, TC1572314
DoTS DT.101374584, DT.94377781, DT.101266055, DT.94303614
NIA Mouse Gene Index U033646
EC 1.3.3.6
Consensus CDS Project CCDS25660.1, CCDS70354.1
International Mouse Phenotyping Consortium Status Acox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003754 VEGA Gene Model | MGI Sequence Detail 27158 C57BL/6J ±  kb
transcript OTTMUST00000008212 VEGA | MGI Sequence Detail 3987 Not Applicable 
polypeptide OTTMUSP00000003995 VEGA | MGI Sequence Detail 661 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(193 from dbSNP Build 137)    SNPs within 2kb including multiple locations(199)
Protein-related
information
ResourceIDDescription
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR012258 Acyl-CoA oxidase
InterPro IPR002655 Acyl-CoA oxidase, C-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003642 peroxisomal acyl-coenzyme A oxidase 1
References
(Earliest) J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
(Latest) J:216841 Riordan JD, et al., Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse. Mamm Genome. 2014 Oct;25(9-10):473-86
All references(74)
Disease annotation references (1)
Other
accession IDs
MGI:2141377, MGI:2441945

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory