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Acox1 Gene Detail
Summary
  • Symbol
    Acox1
  • Name
    acyl-Coenzyme A oxidase 1, palmitoyl
  • Synonyms
    Acyl-CoA oxidase, AOX, D130055E20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330812
    NCBI Gene: 11430
  • Gene Overview
    MyGene.info: ACOX1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:116171888-116199045 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27158 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.96 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ACOX1, acyl-CoA oxidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACOX1, acyl-CoA oxidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACOX, PALMCOX, SCOX
  • Links
    NCBI Gene ID: 51
    neXtProt AC: NX_Q15067
    UniProt: Q15067

  • Chr Location
    17q25.1; chr17:75941507-75979434 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Acox1 mouse models; 1 with human ACOX1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    7 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation that inactivates the gene show growth retardation, infertility, excess very long chain fatty acids in the blood, and progressive liver disease, including hepatomegaly, and hepatic adenomas and carcinomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003754 VEGA Gene Model | MGI Sequence Detail 27158 C57BL/6J ±  kb
    transcript OTTMUST00000008212 VEGA | MGI Sequence Detail 3987 Not Applicable  
    polypeptide OTTMUSP00000003995 VEGA | MGI Sequence Detail 661 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      187 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003642 peroxisomal acyl-coenzyme A oxidase 1
    • EC
    • InterPro Domains
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR012258 Acyl-CoA oxidase
      IPR002655 Acyl-CoA oxidase, C-terminal
      IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
      IPR029320 Acyl-coenzyme A oxidase, N-terminal
      IPR034171 Peroxisomal acyl-coenzyme A oxidase
    Molecular
    Reagents
    less
    • All nucleic 270
      cDNA 266
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141377, MGI:2441945
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
    • Latest
      J:242797 Tzeng J, et al., An Ideal PPAR Response Element Bound to and Activated by PPARalpha. PLoS One. 2015;10(8):e0134996

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory