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Acox1 Gene Detail
Summary
  • Symbol
    Acox1
  • Name
    acyl-Coenzyme A oxidase 1, palmitoyl
  • Synonyms
    Acyl-CoA oxidase, AOX, D130055E20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330812
    NCBI Gene: 11430
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116062714-116089871 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330812
 protein coding gene Chr11:116062709-116089871 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019418
 protein coding gene Chr11:120262206-120293455 (-)
A/J MGP_AJ_G0019387
 protein coding gene Chr11:115009719-115038141 (-)
AKR/J MGP_AKRJ_G0019357
 protein coding gene Chr11:118435182-118461677 (-)
BALB/cJ MGP_BALBcJ_G0019361
 protein coding gene Chr11:115420392-115449862 (-)
C3H/HeJ MGP_C3HHeJ_G0019167
 protein coding gene Chr11:118789674-118817104 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019811
 protein coding gene Chr11:123954110-123985454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017434
 protein coding gene Chr11:112022114-112049978 (-)
CAST/EiJ MGP_CASTEiJ_G0018722
 protein coding gene Chr11:120146723-120177935 (-)
CBA/J MGP_CBAJ_G0019139
 protein coding gene Chr11:128833233-128873033 (-)
DBA/2J MGP_DBA2J_G0019250
 protein coding gene Chr11:114426510-114453092 (-)
FVB/NJ MGP_FVBNJ_G0019242
 protein coding gene Chr11:113941742-113968920 (-)
LP/J MGP_LPJ_G0019320
 protein coding gene Chr11:120643919-120672663 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019275
 protein coding gene Chr11:127924728-127955027 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019849
 protein coding gene Chr11:119095904-119123560 (-)
PWK/PhJ MGP_PWKPhJ_G0018486
 protein coding gene Chr11:115760433-115788809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018279
 protein coding gene Chr11:118852255-118880081 (-)
WSB/EiJ MGP_WSBEiJ_G0018774
 protein coding gene Chr11:119060460-119094726 (-)



Homology
more
  • Human Ortholog
    ACOX1, acyl-CoA oxidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOX1, acyl-CoA oxidase 1
  • Synonyms
    ACOX, MITCH, PALMCOX, SCOX
  • Links
    NCBI Gene ID: 51
    neXtProt AC: NX_Q15067
    UniProt: Q15067

  • Chr Location
    17q25.1; chr17:75941507-75979434 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Acox1 mouse models; 1 with human ACOX1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    7 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation that inactivates the gene show growth retardation, infertility, excess very long chain fatty acids in the blood, and progressive liver disease, including hepatomegaly, and hepatic adenomas and carcinomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    980
  • Tissues
    172
  • cDNA Data
    260
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020777 Ensembl Gene Model | MGI Sequence Detail 27158 C57BL/6J ±  kb
    transcript ENSMUST00000066587 Ensembl | MGI Sequence Detail 3987 Not Applicable  
    polypeptide ENSMUSP00000063325 Ensembl | MGI Sequence Detail 661 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003642 peroxisomal acyl-coenzyme A oxidase 1
      (term hierarchy)
    • EC
      1.3.3.6
    • InterPro Domains
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR012258 Acyl-CoA oxidase
      IPR002655 Acyl-CoA oxidase, C-terminal
      IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
      IPR029320 Acyl-coenzyme A oxidase, N-terminal
      IPR034171 Peroxisomal acyl-coenzyme A oxidase
    Molecular
    Reagents
    less
    • All nucleic 271
      cDNA 266
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141377, MGI:2441945
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
    • Latest
      J:297170 He A, et al., Acetyl-CoA Derived from Hepatic Peroxisomal beta-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. Mol Cell. 2020 Jul 2;79(1):30-42.e4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/26/2022
    MGI 6.21     		The Jackson Laboratory