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Rab33b
Gene Detail
Symbol

Name
ID
Rab33b
RAB33B, member RAS oncogene family
MGI:1330805
Feature Type
protein coding gene
Genetic Map
Chromosome 3
22.49 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:51483966-51495905 bp, + strand
From VEGA annotation of GRCm38

  11940 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9642  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab33b

Human
homologs
Human Homolog RAB33B, RAB33B, member RAS oncogene family
NCBI Gene ID 83452
neXtProt AC  NX_Q9H082
Human Synonyms  SMC2
Human Chr (Location)  4q28; chr4:139453807-139475916 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAB33B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix )
Interactions
Rab33b interacts with 265 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process autophagy, GTP catabolic process, ...
Component extracellular vesicular exosome, Golgi apparatus, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) cDNA(56)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028185 (Evidence)
Ensembl Gene ModelENSMUSG00000027739 (Evidence)
Entrez Gene19338 (Evidence)
UniGene1664
DFCITC1575030
DoTSDT.486808, DT.101304196
NIA Mouse Gene IndexU003216
PDB1Z06, 2G77
Consensus CDS ProjectCCDS38427.1
International Mouse Knockout Project StatusRab33b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028185 VEGA Gene Model | MGI Sequence Detail 11940 C57BL/6J ±  kb
transcript OTTMUST00000069820 VEGA | MGI Sequence Detail 3165 Not Applicable 
polypeptide OTTMUSP00000035514 VEGA | MGI Sequence Detail 229 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013609 ras-related protein Rab-33B
References
(Earliest) J:52723 Zheng JY, et al., A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. J Cell Sci. 1998 Apr;111(Pt 8):1061-9
(Latest) J:190086 Itoh T, et al., Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell. 2008 Jul;19(7):2916-25
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory