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Rab33b Gene Detail
Summary
  • Symbol
    Rab33b
  • Name
    RAB33B, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330805
    NCBI Gene: 19338
  • Gene Overview
    MyGene.info: RAB33B
Location & Maps
more
  • Sequence Map
    Chr3:51483920-51496232 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12313 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 22.49 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAB33B, RAB33B, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB33B, RAB33B, member RAS oncogene family
    Orthology source: HomoloGene
  • Synonyms
    SMC2
  • Links
    NCBI Gene ID: 83452
    neXtProt AC: NX_Q9H082

  • Chr Location
    4q28; chr4:139453232-139475916 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RAB33B associations

Human Disease Mouse Models
       Smith-Mccort Dysplasia 2; SMC2   OMIM: 615222
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Rab33b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051613 VEGA Gene Model | MGI Sequence Detail 12313 C57BL/6J ±  kb
transcript OTTMUST00000069820 VEGA | MGI Sequence Detail 3492 Not Applicable  
polypeptide OTTMUSP00000035514 VEGA | MGI Sequence Detail 229 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013609 ras-related protein Rab-33B
  • PDB
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 56
    cDNA 56

    Microarray probesets 3
References
more
  • Summaries
    All 24
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:52723 Zheng JY, et al., A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. J Cell Sci. 1998 Apr;111(Pt 8):1061-9
  • Latest
    J:190086 Itoh T, et al., Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell. 2008 Jul;19(7):2916-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory