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Hnrnpab Gene Detail
Summary
  • Symbol
    Hnrnpab
  • Name
    heterogeneous nuclear ribonucleoprotein A/B
  • Synonyms
    CBF-A, Cgbfa, Hnrpab
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330294
    NCBI Gene: 15384
  • Gene Overview
    MyGene.info: HNRNPAB
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:51600100-51606847 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.11 cM, cytoband B1.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330294
protein coding gene Chr11:51600100-51606881 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018269
protein coding gene Chr11:50847671-50854415 (-)
A/J MGP_AJ_G0018238
protein coding gene Chr11:48934308-48941055 (-)
AKR/J MGP_AKRJ_G0018208
protein coding gene Chr11:50470906-50477653 (-)
BALB/cJ MGP_BALBcJ_G0018209
protein coding gene Chr11:49230262-49237007 (-)
C3H/HeJ MGP_C3HHeJ_G0018020
protein coding gene Chr11:50495769-50502514 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018659
protein coding gene Chr11:52386850-52393595 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016311
protein coding gene Chr11:46498836-46505647 (-)
CAST/EiJ MGP_CASTEiJ_G0017584
protein coding gene Chr11:50494256-50500976 (-)
CBA/J MGP_CBAJ_G0017995
protein coding gene Chr11:54842140-54848894 (-)
DBA/2J MGP_DBA2J_G0018102
protein coding gene Chr11:48643499-48650236 (-)
FVB/NJ MGP_FVBNJ_G0018097
protein coding gene Chr11:48349143-48355882 (-)
LP/J MGP_LPJ_G0018178
protein coding gene Chr11:51272434-51279173 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018120
protein coding gene Chr11:56260041-56266800 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018702
protein coding gene Chr11:50568635-50575367 (-)
PWK/PhJ MGP_PWKPhJ_G0017360
protein coding gene Chr11:49162066-49168916 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017155
protein coding gene Chr11:50302511-50309331 (-)
WSB/EiJ MGP_WSBEiJ_G0017632
protein coding gene Chr11:50222161-50228910 (-)



Homology
more
  • Human Ortholog
    HNRNPAB, heterogeneous nuclear ribonucleoprotein A/B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HNRNPAB, heterogeneous nuclear ribonucleoprotein A/B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABBP1, HNRPAB
  • Links
    NCBI Gene ID: 3182
    neXtProt AC: NX_Q99729
    UniProt: Q99729

  • Chr Location
    5q35.3; chr5:178204507-178211183 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neuron differentiation, increased susceptibility to neuronal excitotoxicity and long neurites.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020358 Ensembl Gene Model | MGI Sequence Detail 6748 C57BL/6J ±  kb
transcript ENSMUST00000109103 Ensembl | MGI Sequence Detail 1437 Not Applicable  
polypeptide ENSMUSP00000104731 Ensembl | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR012956 CARG-binding factor, N-terminal
    IPR034846 hnRNPAB, RNA recognition motif 1
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 25
    cDNA 23
    Primer pair 1
    Other 1

    Microarray probesets 10
Other
Accession IDs
less
MGI:1890913
References
more
  • Summaries
    All 49
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory