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Cd2ap
Gene Detail
 Symbol
Name
ID
Cd2ap
CD2-associated protein
MGI:1330281
Synonyms Mets1, METS-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
19.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:42792951-42876424 bp, - strand
From NCBI annotation of GRCm38

  83474 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7663  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cd2ap

Human
homologs
Human Homolog CD2AP, CD2-associated protein
NCBI Gene ID 23607
neXtProt AC  NX_Q9Y5K6
Human Synonyms  CMS
Human Chr (Location)  6p12; chr6:47477746-47627263 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD2AP
Alleles
and
phenotypes
All alleles(26) : Gene trapped(23) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impaired immune function and die at 6 to 7 weeks of age from kidney failure associated with podocyte defects and mesangial cell hyperplasia. Heterozygotes develop glomerular changes around 9 months.
 
Human Diseases Modeled Using Mouse Cd2ap (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell cycle, cell division, ...
Component cell-cell junction, cell cortex, ...
Function beta-catenin binding, cadherin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (136)    Tissues (90)    Images (22)
Theiler Stages: 17, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 119
Northern blot 8
Western blot 7
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000061665 (Evidence)
Entrez Gene12488 (Evidence)
NIA Mouse Gene IndexU037819, U110508
PDB2JTE, 2KRM, 2KRN, 2KRO, 2MCN, 2LZ6
Consensus CDS ProjectCCDS50114.1
International Mouse Knockout Project StatusCd2ap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12488 NCBI Gene Model | MGI Sequence Detail 83474 C57BL/6J ±  kb
transcript NM_009847 RefSeq | MGI Sequence Detail 5427 Not Specified 
polypeptide Q9JLQ0 UniProt | EBI | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(594 from dbSNP Build 137)    SNPs within 2kb including multiple locations(606)
Protein-related
information
ResourceIDDescription
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000005163 CD2-associated protein
Graphical View of Protein Domain Structure
References (Earliest) J:43777 Jansson S, et al., Mouse metanephric kidney as a model system for identifying developmentally regulated genes. J Cell Physiol. 1997 Nov;173(2):147-51
(Latest) J:207138 Srivatsan S, et al., CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production. J Immunol. 2013 Dec 15;191(12):5933-40
All references(70)
Other
accession IDs
MGI:1194922, MGI:2146959, MGI:2147127

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory