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Tulp3 Gene Detail
Summary
  • Symbol
    Tulp3
  • Name
    tubby-like protein 3
  • Synonyms
    2310022L06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329045
    NCBI Gene: 22158
Location & Maps
more
  • Sequence Map
    Chr6:128321161-128355851 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34691 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TULP3, tubby like protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TULP3, tubby like protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TUBL3
  • Links
    NCBI Gene ID: 7289
    neXtProt AC: NX_O75386
    UniProt: O75386

  • Chr Location
    12p13.33; chr12:2890867-2941140 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit failed neural tube closure followed by neuroepithelial apoptosis and ultimately embryonic death around E14.5. Heterozygotes are largely phenotypically normal, however some exhibit neuroepithelial apoptosis and die as embryos.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022778 VEGA Gene Model | MGI Sequence Detail 34691 C57BL/6J ±  kb
transcript OTTMUST00000054691 VEGA | MGI Sequence Detail 3374 Not Applicable  
polypeptide OTTMUSP00000026129 VEGA | MGI Sequence Detail 460 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    205 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 5
Other
Accession IDs
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MGI:1353642, MGI:1916802
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:51388 Nishina PM, et al., Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans. Genomics. 1998 Dec 1;54(2):215-20
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory