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Clcnka
Gene Detail
 Symbol
Name
ID
Clcnka
chloride channel Ka
MGI:1329026
Synonyms CLC-K1, Clcnk1
Feature Type protein coding gene
Genetic Map
Chromosome 4
73.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:141384610-141398724 bp, - strand
From VEGA annotation of GRCm38

  14115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chloride channel protein ClC-K
Gene Tree: Clcnka

Human
homologs
Human Homolog CLCNKB, chloride channel, voltage-sensitive Kb
NCBI Gene ID 1188
neXtProt AC  NX_P51801
Human Synonyms  ClC-K2, ClC-Kb, CLCKB
Human Chr (Location)  1p36; chr1:16043736-16057326 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CLCNKB
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased urine volume and decreased urine osmolarity.
 
Human Diseases Modeled Using Mouse Clcnka (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Clcnka interacts with 60 markers (Mir19a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process chloride transmembrane transport, chloride transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function adenyl nucleotide binding, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (58)    Tissues (45)    Images (16)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 58
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010291 (Evidence)
Ensembl Gene ModelENSMUSG00000033770 (Evidence)
Entrez Gene12733 (Evidence)
UniGene167900
DFCITC1585185
DoTSDT.101232118, DT.488694
NIA Mouse Gene IndexU025723
Consensus CDS ProjectCCDS18871.1
International Mouse Knockout Project StatusClcnka
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010291 VEGA Gene Model | MGI Sequence Detail 14115 C57BL/6J ±  kb
transcript OTTMUST00000023956 VEGA | MGI Sequence Detail 2511 Not Applicable 
polypeptide OTTMUSP00000010986 VEGA | MGI Sequence Detail 687 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002250 Chloride channel ClC-K
InterPro IPR014743 Chloride channel, core
InterPro IPR001807 Chloride channel, voltage gated
InterPro IPR000644 Cystathionine beta-synthase, core
Protein Ontology PR:000005535 chloride channel protein ClC-Ka
References (Earliest) J:51917 Matsumura Y, et al., Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel [see comments]. Nat Genet. 1999 Jan;21(1):95-8
(Latest) J:198739 Rossier BC, et al., Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension. FEBS Lett. 2013 Jun 27;587(13):1929-41
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:2140644

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory