Clcnka
Gene Detail

Symbol Name ID

Clcnka chloride channel Ka MGI:1329026

Synonyms

CLC-K1, Clcnk1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

73.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:141384610-141398724 bp, - strand From VEGA annotation of GRCm38   14115 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:65  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chloride channel protein ClC-K
Gene Tree: Clcnka

Human homologs

Human Homolog		CLCNKB, chloride channel, voltage-sensitive Kb
NCBI Gene ID		1188
neXtProt AC		NX_P51801
Human Synonyms		ClC-K2, ClC-Kb, CLCKB
Human Chr (Location)		1p36; chr1:16370231-16383821 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CLCNKB

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygous mutation of this gene results in increased urine volume and decreased urine osmolarity.

 
Human Diseases Modeled Using Mouse Clcnka (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	chloride transport, ion transmembrane transport, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	chloride channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (14)    Tissues (1)    Images (14)
Theiler Stages: 23

Assay Type	Results
RNA in situ	14

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000010291 (Evidence)
Ensembl Gene Model	ENSMUSG00000033770 (Evidence)
Entrez Gene	12733 (Evidence)
UniGene	167900
DFCI	TC1585185
DoTS	DT.101232118, DT.488694
NIA Mouse Gene Index	U025723
Consensus CDS Project	CCDS18871.1
International Mouse Knockout Project Status	Clcnka

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010291	VEGA Gene Model | MGI Sequence Detail	14115	C57BL/6J
transcript	OTTMUST00000023955	VEGA | MGI Sequence Detail	2428	Not Applicable
polypeptide	OTTMUSP00000010985	VEGA | MGI Sequence Detail	687	Not Applicable

All sequences(37) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002250	Chloride channel ClC-K
InterPro	IPR014743	Chloride channel, core
InterPro	IPR001807	Chloride channel, voltage gated
InterPro	IPR000644	Cystathionine beta-synthase, core
Protein Ontology	PR:000005535	chloride channel protein ClC-Ka

References

(Earliest) J:51917 Matsumura Y, et al., Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel [see comments]. Nat Genet. 1999 Jan;21(1):95-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)

Other accession IDs

MGI:2140644