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Clcnka
Gene Detail
Symbol

Name
ID
Clcnka
chloride channel Ka
MGI:1329026
Synonyms
CLC-K1, Clcnk1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
73.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:141384610-141398724 bp, - strand
From VEGA annotation of GRCm38

  14115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CLCNKB
Protein SuperFamily: chloride channel protein ClC-K
Gene Tree: Clcnka

Human
homologs
CLCNKB, chloride channel, voltage-sensitive Kb
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1188
neXtProt AC: NX_P51801

Human Synonyms: ClC-K2, ClC-Kb, CLCKB

Human Chr (Location): 1p36; chr1:16043736-16057326 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CLCNKB

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Genomic Mutations involving Clcnka (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in increased urine volume and decreased urine osmolarity.
 
Human Diseases Modeled in Mice Using Clcnka (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Clcnka interacts with 60 markers (Mir19a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process chloride transmembrane transport, chloride transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function chloride channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (58)    Tissues (45)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 58
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010291 (Evidence)
Ensembl Gene Model ENSMUSG00000033770 (Evidence)
Entrez Gene 12733 (Evidence)
UniGene 167900
DFCI TC1585185
DoTS DT.101232118, DT.488694
NIA Mouse Gene Index U025723
Consensus CDS Project CCDS18871.1
International Mouse Phenotyping Consortium Status Clcnka
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010291 VEGA Gene Model | MGI Sequence Detail 14115 C57BL/6J ±  kb
transcript OTTMUST00000023956 VEGA | MGI Sequence Detail 2511 Not Applicable 
polypeptide OTTMUSP00000010986 VEGA | MGI Sequence Detail 687 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002250 Chloride channel ClC-K
InterPro IPR014743 Chloride channel, core
InterPro IPR001807 Chloride channel, voltage gated
InterPro IPR000644 Cystathionine beta-synthase, core
Protein Ontology PR:000005535 chloride channel protein ClC-Ka
References
(Earliest) J:51917 Matsumura Y, et al., Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel [see comments]. Nat Genet. 1999 Jan;21(1):95-8
(Latest) J:204118 L'Hoste S, et al., Characterization of the mouse ClC-K1/Barttin chloride channel. Biochim Biophys Acta. 2013 Nov;1828(11):2399-409
All references(39)
Disease annotation references (1)
Other
accession IDs
MGI:2140644

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory