Automated description from the Alliance of Genome Resources (Release 5.4.0)
Predicted to enable identical protein binding activity and voltage-gated chloride channel activity. Acts upstream of or within regulation of body fluid levels and renal inner medulla development. Located in basolateral plasma membrane. Is expressed in early conceptus; gonad; inner ear; metanephros; and thyroid gland. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to several human genes including CLCNKB (chloride voltage-gated channel Kb).