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Sel1l Gene Detail
Summary
  • Symbol
    Sel1l
  • Name
    sel-1 suppressor of lin-12-like (C. elegans)
  • Synonyms
    Sel1h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329016
    NCBI Gene: 20338
  • Gene Overview
    MyGene.info: SEL1L
Location & Maps
more
  • Sequence Map
    Chr12:91806043-91849157 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43115 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEL1L, SEL1L ERAD E3 ligase adaptor subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEL1L, SEL1L ERAD E3 ligase adaptor subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PRO1063, SEL1L1, SEL1-LIKE
  • Links
    NCBI Gene ID: 6400
    neXtProt AC: NX_Q9UBV2

  • Chr Location
    14q31; chr14:81471547-81533861 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31286
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SEL1L
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Sel1l mouse models

Human Disease Mouse Models
       Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, and Calvarial Hyperostosis   OMIM: 612714 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    8 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    4
  • Genomic Mutations
    1 involving Sel1l
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit prenatal lethality with impaired exocrine and endocrine pancreatic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035560 VEGA Gene Model | MGI Sequence Detail 43115 C57BL/6J ±  kb
transcript OTTMUST00000091086 VEGA | MGI Sequence Detail 6300 Not Applicable  
polypeptide OTTMUSP00000050114 VEGA | MGI Sequence Detail 790 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    538 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2145030
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 3
    Phenotypes 16
  • Earliest
    J:51618 Donoviel DB, et al., Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998 Nov;78(1-2):203-7
  • Latest
    J:215786 Sha H, et al., The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 2014 Sep 2;20(3):458-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory