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Sel1l Gene Detail
Summary
  • Symbol
    Sel1l
  • Name
    sel-1 suppressor of lin-12-like (C. elegans)
  • Synonyms
    Sel1h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329016
    NCBI Gene: 20338
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:91772817-91815931 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 45.02 cM, cytoband E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    538 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329016
 protein coding gene Chr12:91772817-91815931 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020001
 protein coding gene Chr12:92938946-92982252 (-)
A/J MGP_AJ_G0019956
 protein coding gene Chr12:89443723-89487280 (-)
AKR/J MGP_AKRJ_G0019932
 protein coding gene Chr12:91850839-91893931 (-)
BALB/cJ MGP_BALBcJ_G0019942
 protein coding gene Chr12:89731441-89774856 (-)
C3H/HeJ MGP_C3HHeJ_G0019744
 protein coding gene Chr12:92455684-92499060 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020391
 protein coding gene Chr12:95680234-95723371 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018005
 protein coding gene Chr12:86878609-86921243 (-)
CAST/EiJ MGP_CASTEiJ_G0019290
 protein coding gene Chr12:87378973-87424338 (-)
CBA/J MGP_CBAJ_G0019716
 protein coding gene Chr12:99267382-99310462 (-)
DBA/2J MGP_DBA2J_G0019827
 protein coding gene Chr12:88917730-88961041 (-)
FVB/NJ MGP_FVBNJ_G0019816
 protein coding gene Chr12:87785631-87828597 (-)
LP/J MGP_LPJ_G0019903
 protein coding gene Chr12:92737014-92780117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019857
 protein coding gene Chr12:102023401-102067479 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020420
 protein coding gene Chr12:91459991-91503108 (-)
PWK/PhJ MGP_PWKPhJ_G0019054
 protein coding gene Chr12:83507161-83550508 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018850
 protein coding gene Chr12:85607233-85650897 (-)
WSB/EiJ MGP_WSBEiJ_G0019344
 protein coding gene Chr12:92219580-92262651 (-)



Homology
more
  • Human Ortholog
    SEL1L, SEL1L adaptor subunit of SYVN1 ubiquitin ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEL1L, SEL1L adaptor subunit of SYVN1 ubiquitin ligase
  • Synonyms
    Hrd3, PRO1063, SEL1L1, SEL1-LIKE
  • Links
    NCBI Gene ID: 6400
    neXtProt AC: NX_Q9UBV2
    UniProt: Q9UBV2

  • Chr Location
    14q31.1; chr14:81471547-81533853 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SEL1L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    8 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit prenatal lethality with impaired exocrine and endocrine pancreatic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    60
  • cDNA Data
    19
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20338 NCBI Gene Model | MGI Sequence Detail 43115 C57BL/6J ±  kb
    transcript NM_001039089 RefSeq | MGI Sequence Detail 6300 Not Specified  
    polypeptide Q9Z2G6 UniProt | EBI | MGI Sequence Detail 790 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2145030
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 34
    • Earliest
      J:51618 Donoviel DB, et al., Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998 Nov;78(1-2):203-7
    • Latest
      J:345648 Lin LL, et al., SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex. Nat Commun. 2024 Feb 16;15(1):1440
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory