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Sel1l Gene Detail
Summary
  • Symbol
    Sel1l
  • Name
    sel-1 suppressor of lin-12-like (C. elegans)
  • Synonyms
    Sel1h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329016
    NCBI Gene: 20338
  • Gene Overview
    MyGene.info: SEL1L
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:91806043-91849157 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 45.02 cM, cytoband E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    538 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329016
protein coding gene Chr12:91806043-91849157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020001
protein coding gene Chr12:92938946-92982252 (-)
A/J MGP_AJ_G0019956
protein coding gene Chr12:89443723-89487280 (-)
AKR/J MGP_AKRJ_G0019932
protein coding gene Chr12:91850839-91893931 (-)
BALB/cJ MGP_BALBcJ_G0019942
protein coding gene Chr12:89731441-89774856 (-)
C3H/HeJ MGP_C3HHeJ_G0019744
protein coding gene Chr12:92455684-92499060 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020391
protein coding gene Chr12:95680234-95723371 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018005
protein coding gene Chr12:86878609-86921243 (-)
CAST/EiJ MGP_CASTEiJ_G0019290
protein coding gene Chr12:87378973-87424338 (-)
CBA/J MGP_CBAJ_G0019716
protein coding gene Chr12:99267382-99310462 (-)
DBA/2J MGP_DBA2J_G0019827
protein coding gene Chr12:88917730-88961041 (-)
FVB/NJ MGP_FVBNJ_G0019816
protein coding gene Chr12:87785631-87828597 (-)
LP/J MGP_LPJ_G0019903
protein coding gene Chr12:92737014-92780117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019857
protein coding gene Chr12:102023401-102067479 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020420
protein coding gene Chr12:91459991-91503108 (-)
PWK/PhJ MGP_PWKPhJ_G0019054
protein coding gene Chr12:83507161-83550508 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018850
protein coding gene Chr12:85607233-85650897 (-)
WSB/EiJ MGP_WSBEiJ_G0019344
protein coding gene Chr12:92219580-92262651 (-)



Homology
more
  • Human Ortholog
    SEL1L, SEL1L, ERAD E3 ligase adaptor subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEL1L, SEL1L, ERAD E3 ligase adaptor subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRO1063, SEL1L1, SEL1-LIKE
  • Links
    NCBI Gene ID: 6400
    neXtProt AC: NX_Q9UBV2
    UniProt: Q9UBV2

  • Chr Location
    14q31.1; chr14:81471547-81533864 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31286
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SEL1L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    8 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit prenatal lethality with impaired exocrine and endocrine pancreatic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20338 NCBI Gene Model | MGI Sequence Detail 43115 C57BL/6J ±  kb
    transcript NM_001039089 RefSeq | MGI Sequence Detail 6300 Not Specified  
    polypeptide Q9Z2G6 UniProt | EBI | MGI Sequence Detail 790 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2145030
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Gene Ontology 4
      Phenotypes 22
    • Earliest
      J:51618 Donoviel DB, et al., Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998 Nov;78(1-2):203-7
    • Latest
      J:260795 Kim GH, et al., Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. J Clin Invest. 2018 Mar 1;128(3):1125-1140

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory