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Sel1l
Gene Detail
 Symbol
Name
ID
Sel1l
sel-1 suppressor of lin-12-like (C. elegans)
MGI:1329016
Synonyms Sel1h
Feature Type protein coding gene
Genetic Map
Chromosome 12
45.02 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:91806043-91849157 bp, - strand
From VEGA annotation of GRCm38

  43115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31286  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sel1l

Human
homologs
Human Homolog SEL1L, sel-1 suppressor of lin-12-like (C. elegans)
NCBI Gene ID 6400
neXtProt AC  NX_Q9UBV2
Human Synonyms  PRO1063, SEL1L1, SEL1-LIKE
Human Chr (Location)  14q31; chr14:81471547-81533861 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit prenatal lethality with impaired exocrine and endocrine pancreatic development.
 
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process Notch signaling pathway, response to endoplasmic reticulum stress
Component endoplasmic reticulum, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (65)    Tissues (50)    Images (14)
Theiler Stages: 11, 17, 19, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 51
Northern blot 8
Western blot 3
RT-PCR 3
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000035560 (Evidence)
Ensembl Gene ModelENSMUSG00000020964 (Evidence)
Entrez Gene20338 (Evidence)
DFCITC1585123, TC1594419, TC1594991, TC1596508, TC1629330, TC1637363, TC1681403
DoTSDT.101384217, DT.101384218, DT.40142589, DT.87029579, DT.87056868, DT.99863213
NIA Mouse Gene IndexU034232
Consensus CDS ProjectCCDS26091.1, CCDS49137.1
International Mouse Knockout Project StatusSel1l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035560 VEGA Gene Model | MGI Sequence Detail 43115 C57BL/6J ±  kb
transcript OTTMUST00000091086 VEGA | MGI Sequence Detail 6300 Not Applicable 
polypeptide OTTMUSP00000050114 VEGA | MGI Sequence Detail 790 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(8)
Polymorphisms SNPs within 2kb(541 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR013806 Kringle-like fold
InterPro IPR006597 Sel1-like
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000014604 protein sel-1 homolog 1
References (Earliest) J:51618 Donoviel DB, et al., Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998 Nov;78(1-2):203-7
(Latest) J:174809 Francisco AB, et al., Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia. J Biol Chem. 2011 Jun 24;286(25):22275-82
All references(40)
Other
accession IDs
MGI:2145030

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory