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Bard1
Gene Detail
Symbol

Name
ID
Bard1
BRCA1 associated RING domain 1
MGI:1328361
Synonyms
ENSMUSG00000060893, ENSMUSG00000073653
Feature Type
protein coding gene
Genetic Map
Chromosome 1
35.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:71027498-71103146 bp, - strand
From VEGA annotation of GRCm38

  75649 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bard1

Human
homologs
Human Homolog BARD1, BRCA1 associated RING domain 1
NCBI Gene ID 580
neXtProt AC  NX_Q99728
Human Chr (Location)  2q34-q35; chr2:214725646-214809711 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human BARD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(20) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene fail to develop past the egg cylinder stage. The phenotype is similar to that of mice with homozygous for disruptions in Brca1 or homozygous for disruptions in both Bard1 and Brca1.
 
Human Diseases Modeled Using Mouse Bard1 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Bard1 interacts with 289 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (43)    Tissues (41)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 32
Northern blot 8
Western blot 3
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030938 (Evidence)
Ensembl Gene ModelENSMUSG00000026196 (Evidence)
Entrez Gene12021 (Evidence)
DFCITC1585274, TC1600786, TC1604767
DoTSDT.101262254, DT.103561134
NIA Mouse Gene IndexU021453, U229340
EC6.3.2.-
Consensus CDS ProjectCCDS15029.1
International Mouse Knockout Project StatusBard1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030938 VEGA Gene Model | MGI Sequence Detail 75649 C57BL/6J ±  kb
transcript OTTMUST00000076570 VEGA | MGI Sequence Detail 5659 Not Applicable 
polypeptide OTTMUSP00000040336 VEGA | MGI Sequence Detail 765 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(648 from dbSNP Build 137)    SNPs within 2kb including multiple locations(650)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR001357 BRCT domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000004642 BRCA1-associated RING domain protein 1
References
(Earliest) J:50839 Ayi TC, et al., Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. Oncogene. 1998 Oct 22;17(16):2143-8
(Latest) J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
All references(44)
Disease annotation references (1)
Other
accession IDs
MGI:3642437, MGI:3642903

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory