Bard1
Gene Detail

Symbol Name ID

Bard1 BRCA1 associated RING domain 1 MGI:1328361

Synonyms

ENSMUSG00000060893, ENSMUSG00000073653

Feature Type

protein coding gene

Genetic Map

Chromosome 1

35.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:71027498-71103146 bp, - strand From VEGA annotation of GRCm38   75649 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bard1

Human homologs

Human Homolog		BARD1, BRCA1 associated RING domain 1
NCBI Gene ID		580
neXtProt AC		NX_Q99728
Human Chr (Location)		2q34-q35; chr2:215593262-215674428 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human BARD1

Alleles and phenotypes

All alleles(25) : Targeted(5) Gene trapped(20)
 

Mice homozygous for disruptions of this gene fail to develop past the egg cylinder stage. The phenotype is similar to that of mice with homozygous for disruptions in Brca1 or homozygous for disruptions in both Bard1 and Brca1.

 
Human Diseases Modeled Using Mouse Bard1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	DNA repair, negative regulation of apoptotic process, ...
Component	BRCA1-A complex, BRCA1-BARD1 complex, ...
Function	ligase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (43)    Tissues (41)    Images (4)
Theiler Stages: 15, 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	32
Northern blot	8
Western blot	3

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(14)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030938 (Evidence)
Ensembl Gene Model	ENSMUSG00000026196 (Evidence)
Entrez Gene	12021 (Evidence)
DFCI	TC1585274, TC1600786, TC1604767
DoTS	DT.101262254, DT.103561134
NIA Mouse Gene Index	U021453, U229340
EC	6.3.2.-
Consensus CDS Project	CCDS15029.1
International Mouse Knockout Project Status	Bard1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030938	VEGA Gene Model | MGI Sequence Detail	75649	C57BL/6J
transcript	OTTMUST00000076570	VEGA | MGI Sequence Detail	5659	Not Applicable
polypeptide	OTTMUSP00000040336	VEGA | MGI Sequence Detail	765	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(440 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR001357	BRCT domain
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000004642	BRCA1-associated RING domain protein 1

References

(Earliest) J:50839 Ayi TC, et al., Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. Oncogene. 1998 Oct 22;17(16):2143-8
(Latest) J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
All references(43)

Other accession IDs

MGI:3642437, MGI:3642903