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Wfs1
Gene Detail
Symbol

Name
ID
Wfs1
Wolfram syndrome 1 homolog (human)
MGI:1328355
STS
Synonyms
wolframin
Feature Type
protein coding gene
Genetic Map
Chromosome 5
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:36966104-36988982 bp, - strand
From VEGA annotation of GRCm38

  22879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4380  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WFS1
Gene Tree: Wfs1

Human
homologs
WFS1, Wolfram syndrome 1 (wolframin)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7466
neXtProt AC: NX_O76024

Human Synonyms: CTRCT41, WFRS, WFS, WFSL

Human Chr (Location): 4p16.1; chr4:6269850-6303265 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human WFS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Gene trapped(2) Radiation induced(5) Targeted(8)
Genomic Mutations involving Wfs1 (6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit decreased pancreatic beta cells and impaired glucose tolerance. Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, decreased body weight, and abnormal behavior associated with increased sensitivity to stress.
 
Human Diseases Modeled in Mice Using Wfs1 (1)    Mutations Annotated to Human Diseases (7)    Phenotype Images(4)
Interactions
Wfs1 interacts with 139 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (118)    Tissues (8)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
RT-PCR 1
cDNA source data(50)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase wfs1 ; ZFIN wfs1a, wfs1b    NEW 
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035647 (Evidence)
Ensembl Gene Model ENSMUSG00000039474 (Evidence)
Entrez Gene 22393 (Evidence)
UniGene 20916
DFCI TC1668387, TC1769537, TC1589955, TC1576735
DoTS DT.101399960, DT.110638640, DT.110638615, DT.531070, DT.94201339
NIA Mouse Gene Index U026127
Consensus CDS Project CCDS19245.1
International Mouse Phenotyping Consortium Status Wfs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035647 VEGA Gene Model | MGI Sequence Detail 22879 C57BL/6J ±  kb
transcript OTTMUST00000091241 VEGA | MGI Sequence Detail 3564 Not Applicable 
polypeptide OTTMUSP00000050236 VEGA | MGI Sequence Detail 890 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026208 Wolframin
InterPro IPR026209 Wolframin family
Protein Ontology PR:000017414 wolframin
References
(Earliest) J:50118 Inoue H, et al., A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet. 1998 Oct;20(2):143-8
(Latest) J:217751 Zatyka M, et al., Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression. Hum Mol Genet. 2015 Feb 1;24(3):814-27
All references(70)
Disease annotation references (9)
Other
accession IDs
MGI:2140914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory