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Wfs1 Gene Detail
Summary
  • Symbol
    Wfs1
  • Name
    Wolfram syndrome 1 homolog (human)
  • Synonyms
    wolframin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328355
    NCBI Gene: 22393
  • Gene Overview
    MyGene.info: WFS1
Location & Maps
more
  • Sequence Map
    Chr5:36966104-36989205 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23102 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 19.46 cM
  • Mapping Data
    3 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    WFS1, wolframin ER transmembrane glycoprotein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WFS1, wolframin ER transmembrane glycoprotein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTRCT41, WFRS, WFS, WFSL
  • Links
    NCBI Gene ID: 7466
    neXtProt AC: NX_O76024

  • Chr Location
    4p16.1; chr4:6269850-6303265 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4380
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: WFS1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Wfs1 mouse models; 5 with human WFS1 associations

Human Disease Mouse Models
       Wolfram Syndrome 1; WFS1   OMIM: 222300 View 5 models
       Cataract 41; CTRCT41   OMIM: 116400
Deafness, Autosomal Dominant 6; DFNA6   OMIM: 600965
Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853
Wolfram-Like Syndrome, Autosomal Dominant; WFSL   OMIM: 614296
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 3 alleles in 6 genetic backgrounds
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    8
  • Genomic Mutations
    9 involving Wfs1
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased pancreatic beta cells and impaired glucose tolerance. Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, decreased body weight, and abnormal behavior associated with increased sensitivity to stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035647 VEGA Gene Model | MGI Sequence Detail 23102 C57BL/6J ±  kb
transcript OTTMUST00000091241 VEGA | MGI Sequence Detail 3787 Not Applicable  
polypeptide OTTMUSP00000050236 VEGA | MGI Sequence Detail 890 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    196 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 51
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140914
References
more
  • Summaries
    All 68
    Developmental Gene Expression 4
    Diseases 10
    Gene Ontology 11
    Phenotypes 56
  • Earliest
    J:50118 Inoue H, et al., A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet. 1998 Oct;20(2):143-8
  • Latest
    J:223646 Tein K, et al., Prohormone convertase 2 activity is increased in the hippocampus of Wfs1 knockout mice. Front Mol Neurosci. 2015;8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory