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Wfs1
Gene Detail
 Symbol
Name
ID
Wfs1
Wolfram syndrome 1 homolog (human)
MGI:1328355
STS D5Dmo1
Synonyms wolframin
Feature Type protein coding gene
Genetic Map
Chromosome 5
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:36966104-36988982 bp, - strand
From VEGA annotation of GRCm38

  22879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4380  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Wfs1

Human
homologs
Human Homolog WFS1, Wolfram syndrome 1 (wolframin)
NCBI Gene ID 7466
neXtProt AC  NX_O76024
Human Synonyms  CTRCT41, WFRS, WFS, WFSL
Human Chr (Location)  4p16.1; chr4:6269850-6303265 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human WFS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(2) Radiation induced(4) Targeted(8)
Genomic Mutations involving Wfs1 (5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased pancreatic beta cells and impaired glucose tolerance. Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, decreased body weight, and abnormal behavior associated with increased sensitivity to stress.
 
Human Diseases Modeled Using Mouse Wfs1 (1)    Alleles Annotated to Human Diseases(6)   
Interactions
Wfs1 interacts with 140 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process calcium ion homeostasis, endoplasmic reticulum calcium ion homeostasis, ...
Component endoplasmic reticulum, integral component of endoplasmic reticulum membrane, ...
Function activating transcription factor binding, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (8)    Images (24)
Theiler Stages: 23, 24
Assay TypeResults
RNA in situ 117
RT-PCR 1
cDNA source data(50)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035647 (Evidence)
Ensembl Gene ModelENSMUSG00000039474 (Evidence)
Entrez Gene22393 (Evidence)
UniGene20916
DFCITC1576735, TC1589955, TC1668387, TC1769537
DoTSDT.101399960, DT.110638615, DT.110638640, DT.531070, DT.94201339
NIA Mouse Gene IndexU026127
Consensus CDS ProjectCCDS19245.1
International Mouse Knockout Project StatusWfs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035647 VEGA Gene Model | MGI Sequence Detail 22879 C57BL/6J ±  kb
transcript OTTMUST00000091241 VEGA | MGI Sequence Detail 3564 Not Applicable 
polypeptide OTTMUSP00000050236 VEGA | MGI Sequence Detail 890 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026208 Wolframin
InterPro IPR026209 Wolframin family
Protein Ontology PR:000017414 wolframin
References (Earliest) J:50118 Inoue H, et al., A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet. 1998 Oct;20(2):143-8
(Latest) J:201277 Nakabayashi H, et al., Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1beta gene expression in pancreatic islet beta-cells. Biochem Biophys Res Commun. 2013 May 3;434(2):370-5
All references(61)
Disease annotation references (2)
Other
accession IDs
MGI:2140914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory