Wfs1
Gene Detail

Symbol Name ID

Wfs1 Wolfram syndrome 1 homolog (human) MGI:1328355

STS

D5Dmo1

Synonyms

wolframin

Feature Type

protein coding gene

Genetic Map

Chromosome 5

19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:36966104-36988982 bp, - strand From VEGA annotation of GRCm38   22879 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4380  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Wfs1

Human homologs

Human Homolog		WFS1, Wolfram syndrome 1 (wolframin)
NCBI Gene ID		7466
neXtProt AC		NX_O76024
Human Synonyms		WFRS, WFS, WFSL
Human Chr (Location)		4p16.1; chr4:6271577-6304992 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human WFS1

Alleles and phenotypes

All alleles(10) : Targeted(8) Gene trapped(2)
 

Mice homozygous for a null allele exhibit decreased pancreatic beta cells and impaired glucose tolerance. Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, decreased body weight, and abnormal behavior associated with increased sensitivity to stress.

 
Human Diseases Modeled Using Mouse Wfs1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	calcium ion homeostasis, endoplasmic reticulum calcium ion homeostasis, ...
Component	endoplasmic reticulum, integral to endoplasmic reticulum membrane, ...
Function	activating transcription factor binding, ATPase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (8)    Images (24)
Theiler Stages: 23, 24

Assay Type	Results
RNA in situ	117
RT-PCR	1

cDNA source data(50)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035647 (Evidence)
Ensembl Gene Model	ENSMUSG00000039474 (Evidence)
Entrez Gene	22393 (Evidence)
UniGene	20916
DFCI	TC1576735, TC1589955, TC1668387, TC1769537
DoTS	DT.101399960, DT.110638615, DT.110638640, DT.531070, DT.94201339
NIA Mouse Gene Index	U026127
Consensus CDS Project	CCDS19245.1
International Mouse Knockout Project Status	Wfs1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035647	VEGA Gene Model | MGI Sequence Detail	22879	C57BL/6J
transcript	OTTMUST00000091241	VEGA | MGI Sequence Detail	3564	Not Applicable
polypeptide	OTTMUSP00000050236	VEGA | MGI Sequence Detail	890	Not Applicable

All sequences(53) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(111 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026208	Wolframin
InterPro	IPR026209	Wolframin family
Protein Ontology	PR:000017414	wolframin

References

(Earliest) J:50118 Inoue H, et al., A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet. 1998 Oct;20(2):143-8
(Latest) J:196523 Fonseca SG, et al., Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol. 2012 Oct;14(10):1105-12
All references(59)

Other accession IDs

MGI:2140914