Symbol
Name
ID

Wfs1
wolframin ER transmembrane glycoprotein
MGI:1328355

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased level of 1,5 anhydroglucitol in serum	Hyperglycemia	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance	Ketoacidosis	Basal ganglia calcification
Disease(s) Associated with WFS1	Decreased level of 1,5 anhydroglucitol in serum	Hyperglycemia	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance	Ketoacidosis	Basal ganglia calcification
autosomal dominant Wolfram syndrome
optic atrophy
type 1 diabetes mellitus
type 2 diabetes mellitus
Wolfram syndrome
Wolfram syndrome 1

Mouse Phenotypes

homeostasis/metabolism phenotype

increased glucagon secretion

decreased insulin secretion

abnormal blood homeostasis

decreased circulating glucose level

increased circulating glucose level

hyperglycemia

increased circulating corticosterone level

decreased circulating insulin level

increased circulating insulin-like growth factor I level

decreased circulating leptin level

increased oxygen consumption

abnormal glucose homeostasis

impaired glucose tolerance

Availability

Mouse Genotype

Wfs1^tm1Koks/Wfs1^tm1Koks

Wfs1^tm1Yoka/Wfs1^tm1Yoka

Wfs1^tm1Koks/Wfs1⁺

Wfs1^tm1Perm/Wfs1^tm1Perm
Tg(Ins2-cre)23Herr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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