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Orc1
Gene Detail
Symbol

Name
ID
Orc1
origin recognition complex, subunit 1
MGI:1328337
Synonyms
MmORC1, Orc1l
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.64 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:108579423-108614833 bp, + strand
From VEGA annotation of GRCm38

  35411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Orc1

Human
homologs
Human Homolog ORC1, origin recognition complex, subunit 1
NCBI Gene ID 4998
neXtProt AC  NX_Q13415
Human Synonyms  HSORC1, ORC1L, PARC1
Human Chr (Location)  1p32; chr1:52372829-52404471 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ORC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(61) : Gene trapped(58) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Orc1 interacts with 133 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process DNA replication, positive regulation of G0 to G1 transition, ...
Component cytoplasm, nuclear origin of replication recognition complex, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(47)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008240 (Evidence)
Ensembl Gene ModelENSMUSG00000028587 (Evidence)
Entrez Gene18392 (Evidence)
UniGene294154
DFCITC1651237, TC1578091
DoTSDT.87031554, DT.485128, DT.101374996, DT.110822359, DT.101220153
NIA Mouse Gene IndexU004623
PDB4DOW, 4DOV
Consensus CDS ProjectCCDS18453.1
International Mouse Knockout Project StatusOrc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008240 VEGA Gene Model | MGI Sequence Detail 35411 C57BL/6J ±  kb
transcript OTTMUST00000018729 VEGA | MGI Sequence Detail 3014 Not Applicable 
polypeptide OTTMUSP00000008599 VEGA | MGI Sequence Detail 840 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(5) UniProt(11)
Polymorphisms
SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR015163 CDC6, C-terminal domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012030 origin recognition complex subunit 1
References
(Earliest) J:51511 Zisimopoulou P, et al., Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1. Mol Gen Genet. 1998 Nov;260(2-3):295-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGI:2140163

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory