About   Help   FAQ
Orc1 Gene Detail
Summary
  • Symbol
    Orc1
  • Name
    origin recognition complex, subunit 1
  • Synonyms
    MmORC1, Orc1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328337
    NCBI Gene: 18392
  • Gene Overview
    MyGene.info: ORC1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:108579423-108614833 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.64 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328337
protein coding gene Chr4:108575620-108616030 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028557
protein coding gene Chr4:109329573-109366373 (+)
A/J MGP_AJ_G0028520
protein coding gene Chr4:105388929-105424947 (+)
AKR/J MGP_AKRJ_G0028467
protein coding gene Chr4:108010239-108052198 (+)
BALB/cJ MGP_BALBcJ_G0028539
protein coding gene Chr4:105598359-105634070 (+)
C3H/HeJ MGP_C3HHeJ_G0028253
protein coding gene Chr4:108735748-108774470 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028979
protein coding gene Chr4:113247515-113282533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026270
protein coding gene Chr4:100678690-100710317 (+)
CAST/EiJ MGP_CASTEiJ_G0027689
protein coding gene Chr4:106595708-106632425 (+)
CBA/J MGP_CBAJ_G0028222
protein coding gene Chr4:116977065-117012621 (+)
DBA/2J MGP_DBA2J_G0028370
protein coding gene Chr4:105022503-105057764 (+)
FVB/NJ MGP_FVBNJ_G0028338
protein coding gene Chr4:103889478-103924820 (+)
LP/J MGP_LPJ_G0028471
protein coding gene Chr4:109571494-109608315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028364
protein coding gene Chr4:122170540-122209176 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029015
protein coding gene Chr4:108257148-108291463 (+)
PWK/PhJ MGP_PWKPhJ_G0027415
protein coding gene Chr4:103290852-103332933 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027239
protein coding gene Chr4:105589010-105623240 (+)
WSB/EiJ MGP_WSBEiJ_G0027770
protein coding gene Chr4:108434644-108470009 (+)



Homology
more
  • Human Ortholog
    ORC1, origin recognition complex subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ORC1, origin recognition complex subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSORC1, ORC1L, PARC1
  • Links
    NCBI Gene ID: 4998
    neXtProt AC: NX_Q13415
    UniProt: Q13415

  • Chr Location
    1p32.3; chr1:52371408-52404471 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31221
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ORC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ORC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028587 Ensembl Gene Model | MGI Sequence Detail 35411 C57BL/6J ±  kb
transcript ENSMUST00000102744 Ensembl | MGI Sequence Detail 3014 Not Applicable  
polypeptide ENSMUSP00000099805 Ensembl | MGI Sequence Detail 840 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140163
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:51511 Zisimopoulou P, et al., Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1. Mol Gen Genet. 1998 Nov;260(2-3):295-9
  • Latest
    J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory