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Orc1 Gene Detail
Summary
  • Symbol
    Orc1
  • Name
    origin recognition complex, subunit 1
  • Synonyms
    MmORC1, Orc1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328337
    NCBI Gene: 18392
  • Gene Overview
    MyGene.info: ORC1
Location & Maps
more
  • Sequence Map
    Chr4:108579423-108614833 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35411 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.64 cM, cytoband D
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ORC1, origin recognition complex subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ORC1, origin recognition complex subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSORC1, ORC1L, PARC1
  • Links
    NCBI Gene ID: 4998
    neXtProt AC: NX_Q13415

  • Chr Location
    1p32; chr1:52372829-52404471 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31221
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ORC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ORC1 associations

Human Disease Mouse Models
       Meier-Gorlin Syndrome 1; MGORS1   OMIM: 224690
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    65
  • Chemically induced (other)
    2
  • Gene trapped
    58
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Orc1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008240 VEGA Gene Model | MGI Sequence Detail 35411 C57BL/6J ±  kb
transcript OTTMUST00000018729 VEGA | MGI Sequence Detail 3014 Not Applicable  
polypeptide OTTMUSP00000008599 VEGA | MGI Sequence Detail 840 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    207 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140163
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:51511 Zisimopoulou P, et al., Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1. Mol Gen Genet. 1998 Nov;260(2-3):295-9
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory