Orc1
Gene Detail

Symbol Name ID

Orc1 origin recognition complex, subunit 1 MGI:1328337

Synonyms

MmORC1, Orc1l

Feature Type

protein coding gene

Genetic Map

Chromosome 4

50.64 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:108579423-108614833 bp, + strand From VEGA annotation of GRCm38   35411 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Orc1

Human homologs

Human Homolog		ORC1, origin recognition complex, subunit 1
NCBI Gene ID		4998
neXtProt AC		NX_Q13415
Human Synonyms		HSORC1, ORC1L, PARC1
Human Chr (Location)		1p32; chr1:52838501-52870143 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ORC1

Alleles and phenotypes

All alleles(60) : Targeted(2) Gene trapped(58)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	DNA replication
Component	cytoplasm, nuclear origin of replication recognition complex, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) cDNA(46)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008240 (Evidence)
Ensembl Gene Model	ENSMUSG00000028587 (Evidence)
Entrez Gene	18392 (Evidence)
UniGene	294154
DFCI	TC1578091, TC1651237
DoTS	DT.101220153, DT.101374996, DT.110822359, DT.485128, DT.87031554
NIA Mouse Gene Index	U004623
PDB	4DOV, 4DOW
Consensus CDS Project	CCDS18453.1
International Mouse Knockout Project Status	Orc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008240	VEGA Gene Model | MGI Sequence Detail	35411	C57BL/6J
transcript	OTTMUST00000018729	VEGA | MGI Sequence Detail	3014	Not Applicable
polypeptide	OTTMUSP00000008599	VEGA | MGI Sequence Detail	840	Not Applicable

All sequences(45) RefSeq(3) UniProt(6)

Polymorphisms

SNPs(165 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR001025	Bromo adjacent homology (BAH) domain
InterPro	IPR015163	CDC6, C-terminal domain
InterPro	IPR020793	Origin recognition complex, subunit 1
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000012030	origin recognition complex subunit 1

References

(Earliest) J:51511 Zisimopoulou P, et al., Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1. Mol Gen Genet. 1998 Nov;260(2-3):295-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Other accession IDs

MGI:2140163