Ltbp4
Gene Detail

Symbol Name ID

Ltbp4 latent transforming growth factor beta binding protein 4 MGI:1321395

Synonyms

2310046A13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

15.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:27305136-27337692 bp, - strand From VEGA annotation of GRCm38   32557 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ltbp4

Human homologs

Human Homolog		LTBP4, latent transforming growth factor beta binding protein 4
NCBI Gene ID		8425
neXtProt AC		NX_Q8N2S1
Human Synonyms		ARCL1C, LTBP-4, LTBP4L, LTBP4S
Human Chr (Location)		19q13.1-q13.2; chr19:41099072-41135725 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LTBP4

Alleles and phenotypes

All alleles(128) : Targeted(1) Gene trapped(125) QTL(2)
 

Homozygous disruption of this locus results in pulmonary emphysema, cardiomyopathy, and colon cancer.

 
Human Diseases Modeled Using Mouse Ltbp4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	hormone secretion, regulation of proteolysis, ...
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (7)    Tissues (7)    Images (5)
Theiler Stages: 20, 22, 24, 28

Assay Type	Results
RNA in situ	7

cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031915 (Evidence)
Ensembl Gene Model	ENSMUSG00000040488 (Evidence)
Entrez Gene	108075 (Evidence)
UniGene	272251
DFCI	TC1577215, TC1603255, TC1616845, TC1685002
DoTS	DT.101220796, DT.102548500, DT.534836, DT.91293664, DT.91553823, DT.97398416
NIA Mouse Gene Index	U028299
Consensus CDS Project	CCDS21017.1, CCDS52158.1
International Mouse Knockout Project Status	Ltbp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031915	VEGA Gene Model | MGI Sequence Detail	32557	C57BL/6J
transcript	OTTMUST00000079136	VEGA | MGI Sequence Detail	5386	Not Applicable
polypeptide	OTTMUSP00000042166	VEGA | MGI Sequence Detail	1666	Not Applicable

All sequences(75) RefSeq(4) UniProt(8)

Polymorphisms

SNPs(132 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026823	Complement Clr-like EGF domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR017878	TB domain
Protein Ontology	PR:000009975	latent-transforming growth factor beta-binding protein 4

References

(Earliest) J:47007 Thorey IS, et al., Selective disruption of genes transiently induced in differentiating mouse embryonic stem cells by using gene trap mutagenesis and site-specific recombination. Mol Cell Biol. 1998 May;18(5):3081-8
(Latest) J:194311 Noda K, et al., Latent TGF-beta binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2852-7
All references(50)

Other accession IDs

MGI:1916894