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Ltbp4
Gene Detail
Symbol

Name
ID
Ltbp4
latent transforming growth factor beta binding protein 4
MGI:1321395
Synonyms
2310046A13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
15.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:27305136-27337692 bp, - strand
From VEGA annotation of GRCm38

  32557 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LTBP4
Gene Tree: Ltbp4

Human
homologs
LTBP4, latent transforming growth factor beta binding protein 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8425
neXtProt AC: NX_Q8N2S1

Human Synonyms: ARCL1C, LTBP-4, LTBP4L, LTBP4S

Human Chr (Location): 19q13.1-q13.2; chr19:40592888-40629820 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LTBP4

Mutations,
alleles, and
phenotypes
All mutations/alleles(129) : Gene trapped(125) QTL(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous disruption of this locus results in pulmonary emphysema, cardiomyopathy, and colon cancer.
 
Human Diseases Modeled in Mice Using Ltbp4 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Ltbp4 interacts with 57 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process hormone secretion, regulation of proteolysis, ...
Component cell, extracellular exosome, ...
Function calcium ion binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (7)    Tissues (7)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(97)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100488208    NEW 
Molecular
reagents
All nucleic(100) cDNA(99) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031915 (Evidence)
Ensembl Gene Model ENSMUSG00000040488 (Evidence)
Entrez Gene 108075 (Evidence)
UniGene 272251
DFCI TC1577215, TC1603255, TC1616845, TC1685002
DoTS DT.101220796, DT.102548500, DT.534836, DT.91293664, DT.91553823, DT.97398416
NIA Mouse Gene Index U028299
Consensus CDS Project CCDS21017.1, CCDS52158.1
International Mouse Phenotyping Consortium Status Ltbp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031915 VEGA Gene Model | MGI Sequence Detail 32557 C57BL/6J ±  kb
transcript OTTMUST00000079136 VEGA | MGI Sequence Detail 5386 Not Applicable 
polypeptide OTTMUSP00000042166 VEGA | MGI Sequence Detail 1666 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(10) UniProt(8)
Polymorphisms
SNPs within 2kb(234 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026823 Complement Clr-like EGF domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017878 TB domain
Protein Ontology PR:000009975 latent-transforming growth factor beta-binding protein 4
References
(Earliest) J:47007 Thorey IS, et al., Selective disruption of genes transiently induced in differentiating mouse embryonic stem cells by using gene trap mutagenesis and site-specific recombination. Mol Cell Biol. 1998 May;18(5):3081-8
(Latest) J:221200 Bultmann-Mellin I, et al., Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms. Dis Model Mech. 2015 Apr;8(4):403-15
All references(52)
Disease annotation references (2)
Other
accession IDs
MGI:1916894

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory