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Enpp2
Gene Detail
Symbol

Name
ID
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
MGI:1321390
Synonyms
ATX, Autotaxin, Npps2, PD-Ialpha, Pdnp2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
21.60 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:54838901-54920018 bp, - strand
From VEGA annotation of GRCm38

  81118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4526  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ENPP2
Protein SuperFamily: ectonucleotide pyrophosphatase/phosphodiesterase
Gene Tree: Enpp2

Human
homologs
ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5168
neXtProt AC: NX_Q13822

Human Synonyms: ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2

Human Chr (Location): 8q24.1; chr8:119557077-119673404 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis, absent yolk sac vasculature, abnormal vasculature, and variable penetrance of impaired embryo turning, edema, failure of chorioallantoic fusion, neural tube malformations, and abnormal forebrain development.
 
Interactions
Enpp2 interacts with 141 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cell chemotaxis, chemotaxis, ...
Component cytoplasm, extracellular region, ...
Function alkylglycerophosphoethanolamine phosphodiesterase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (724)    Tissues (339)    Images (135)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 717
RT-PCR 7
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ENPP2 ; Xenbase enpp2 ; ZFIN enpp2    NEW 
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037584 (Evidence)
Ensembl Gene Model ENSMUSG00000022425 (Evidence)
Entrez Gene 18606 (Evidence)
DFCI TC1634487, TC1609467, TC1593539, TC1572746, TC1723116, TC1689332
DoTS DT.492943, DT.101736041, DT.91356347, DT.101377531, DT.101736040, DT.101225419, DT.110812060
NIA Mouse Gene Index U036174
EC 3.1.4.39
PDB 3NKQ, 3NKO, 3NKP, 3NKN, 3NKM, 3WAV, 3NKR, 4GTZ, 3WAX, 4GTY, 3WAW, 4GTX, 3WAY, 4GTW
Consensus CDS Project CCDS27472.1, CCDS49607.1, CCDS70628.1, CCDS70629.1
International Mouse Phenotyping Consortium Status Enpp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037584 VEGA Gene Model | MGI Sequence Detail 81118 C57BL/6J ±  kb
transcript OTTMUST00000096906 VEGA | MGI Sequence Detail 2887 Not Applicable 
polypeptide OTTMUSP00000054213 VEGA | MGI Sequence Detail 910 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(20) UniProt(2)
Polymorphisms
SNPs within 2kb(543 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR001604 DNA/RNA non-specific endonuclease
InterPro IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family
InterPro IPR020821 Extracellular Endonuclease, subunit A
InterPro IPR020436 Somatomedin B, chordata
InterPro IPR001212 Somatomedin B domain
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Protein Ontology PR:000007088 ectonucleotide pyrophosphatase/phosphodiesterase family member 2
References
(Earliest) J:21382 Narita M, et al., Molecular cloning, expression, and localization of a brain-specific phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from rat brain. J Biol Chem. 1994 Nov 11;269(45):28235-42
(Latest) J:202516 Grisanti L, et al., Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis. J Invest Dermatol. 2013 Oct;133(10):2332-9
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory