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Enpp2 Gene Detail
Summary
  • Symbol
    Enpp2
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 2
  • Synonyms
    ATX, Autotaxin, Npps2, PD-Ialpha, Pdnp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321390
    NCBI Gene: 18606
  • Gene Overview
    MyGene.info: ENPP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54838901-54952887 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 21.60 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    743 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321390
protein coding gene Chr15:54838901-54952892 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021850
protein coding gene Chr15:53896727-53981415 (-)
A/J MGP_AJ_G0021810
protein coding gene Chr15:51759373-51841777 (-)
AKR/J MGP_AKRJ_G0021791
protein coding gene Chr15:53225508-53307946 (-)
BALB/cJ MGP_BALBcJ_G0021817
protein coding gene Chr15:51985064-52067412 (-)
C3H/HeJ MGP_C3HHeJ_G0021591
protein coding gene Chr15:53308105-53398496 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022256
protein coding gene Chr15:55979600-56068474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019793
protein coding gene Chr15:48999357-49080649 (-)
CAST/EiJ MGP_CASTEiJ_G0021108
protein coding gene Chr15:53890763-53974257 (-)
CBA/J MGP_CBAJ_G0021560
protein coding gene Chr15:57996913-58077409 (-)
DBA/2J MGP_DBA2J_G0021684
protein coding gene Chr15:51654082-51735962 (-)
FVB/NJ MGP_FVBNJ_G0021662
protein coding gene Chr15:50777006-50857382 (-)
LP/J MGP_LPJ_G0021754
protein coding gene Chr15:53685521-53767663 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021686
protein coding gene Chr15:63070286-63156605 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022279
protein coding gene Chr15:53566306-53655892 (-)
PWK/PhJ MGP_PWKPhJ_G0020853
protein coding gene Chr15:51723648-51805101 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020690
protein coding gene Chr15:53310401-53395387 (-)
WSB/EiJ MGP_WSBEiJ_G0021163
protein coding gene Chr15:53554010-53641274 (-)



Homology
more
  • Human Ortholog
    ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
  • Links
    NCBI Gene ID: 5168
    neXtProt AC: NX_Q13822
    UniProt: Q13822

  • Chr Location
    8q24.12; chr8:119557077-119673404 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 7 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis, absent yolk sac vasculature, abnormal vasculature, and variable penetrance of impaired embryo turning, edema, failure of chorioallantoic fusion, neural tube malformations, and abnormal forebrain development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18606 NCBI Gene Model | MGI Sequence Detail 113987 C57BL/6J ±  kb
    transcript NM_001136077 RefSeq | MGI Sequence Detail 3413 C57BL/6  
    polypeptide Q9R1E6 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264111 Liu CF, et al., SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. Development. 2018 Jul 18;145(14)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory