Enpp2
Gene Detail

Symbol Name ID

Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 MGI:1321390

Synonyms

ATX, Autotaxin, Npps2, PD-Ialpha, Pdnp2

Feature Type

protein coding gene

Genetic Map

Chromosome 15

21.60 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:54838901-54920018 bp, - strand From VEGA annotation of GRCm38   81118 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Enpp2 ± 2 cM)

Protein SuperFamily: ectonucleotide pyrophosphatase/phosphodiesterase
Gene Tree: Enpp2

Human ortholog

ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 NCBI Gene ID 5168
Human Synonyms: ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
Human Chr8:120569319-120651106 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Mice homozygous for a null mutation display embryonic lethality during organogenesis, absent yolk sac vasculature, abnormal vasculature, and variable penetrance of impaired embryo turning, edema, failure of chorioallantoic fusion, neural tube malformations, and abnormal forebrain development.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	chemotaxis, immune response, ...
Component	extracellular region, extracellular space, ...
Function	alkylglycerophosphoethanolamine phosphodiesterase activity, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (609)    Tissues (265)    Images (96)
Theiler Stages: 13, 15, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	604
RT-PCR	5

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037584 (Evidence)
Ensembl Gene Model	ENSMUSG00000022425 (Evidence)
Entrez Gene	18606 (Evidence)
DFCI	TC1572746, TC1593539, TC1609467, TC1634487, TC1689332, TC1723116
DoTS	DT.101225419, DT.101377531, DT.101736040, DT.101736041, DT.110812060, DT.492943, DT.91356347
NIA Mouse Gene Index	U036174
EC	3.1.4.39
PDB	3NKM, 3NKN, 3NKO, 3NKP, 3NKQ, 3NKR, 4GTW, 4GTX, 4GTY, 4GTZ
Consensus CDS Project	CCDS27472.1, CCDS49607.1
International Mouse Knockout Project Status	Enpp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037584	VEGA Gene Model | MGI Sequence Detail	81118	C57BL/6J
transcript	OTTMUST00000096906	VEGA | MGI Sequence Detail	2887	Not Applicable
polypeptide	OTTMUSP00000054213	VEGA | MGI Sequence Detail	910	Not Applicable

All sequences(58) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(422 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
InterPro	IPR017850	Alkaline-phosphatase-like, core domain
InterPro	IPR001604	DNA/RNA non-specific endonuclease
InterPro	IPR024873	Ectonucleotide pyrophosphatase/phosphodiesterase family
InterPro	IPR020821	Extracellular Endonuclease, subunit A
InterPro	IPR020436	Somatomedin B, chordata
InterPro	IPR001212	Somatomedin B domain
InterPro	IPR002591	Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Protein Ontology	PR:000007088	ectonucleotide pyrophosphatase/phosphodiesterase family member 2

References

(Earliest) J:21382 Narita M, et al., Molecular cloning, expression, and localization of a brain-specific phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from rat brain. J Biol Chem. 1994 Nov 11;269(45):28235-42
(Latest) J:185150 Nikitopoulou I, et al., Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis. J Exp Med. 2012 May 7;209(5):925-33
All references(65)