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Enpp2
Gene Detail
 Symbol
Name
ID
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
MGI:1321390
Synonyms ATX, Autotaxin, Npps2, PD-Ialpha, Pdnp2
Feature Type protein coding gene
Genetic Map
Chromosome 15
21.60 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:54838901-54920018 bp, - strand
From VEGA annotation of GRCm38

  81118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4526  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ectonucleotide pyrophosphatase/phosphodiesterase
Gene Tree: Enpp2

Human
homologs
Human Homolog ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
NCBI Gene ID 5168
neXtProt AC  NX_Q13822
Human Synonyms  ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
Human Chr (Location)  8q24.1; chr8:119557077-119673404 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis, absent yolk sac vasculature, abnormal vasculature, and variable penetrance of impaired embryo turning, edema, failure of chorioallantoic fusion, neural tube malformations, and abnormal forebrain development.
 
Interactions
Enpp2 interacts with 141 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process chemotaxis, immune response, ...
Component extracellular region, extracellular space, ...
Function alkylglycerophosphoethanolamine phosphodiesterase activity, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (724)    Tissues (339)    Images (135)
Theiler Stages: 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 717
RT-PCR 7
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037584 (Evidence)
Ensembl Gene ModelENSMUSG00000022425 (Evidence)
Entrez Gene18606 (Evidence)
DFCITC1572746, TC1593539, TC1609467, TC1634487, TC1689332, TC1723116
DoTSDT.101225419, DT.101377531, DT.101736040, DT.101736041, DT.110812060, DT.492943, DT.91356347
NIA Mouse Gene IndexU036174
EC3.1.4.39
PDB3NKM, 3NKN, 3NKO, 3NKP, 3NKQ, 3NKR, 3WAV, 3WAW, 3WAX, 3WAY, 4GTW, 4GTX, 4GTY, 4GTZ
Consensus CDS ProjectCCDS27472.1, CCDS49607.1, CCDS70628.1, CCDS70629.1
International Mouse Knockout Project StatusEnpp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037584 VEGA Gene Model | MGI Sequence Detail 81118 C57BL/6J ±  kb
transcript OTTMUST00000096906 VEGA | MGI Sequence Detail 2887 Not Applicable 
polypeptide OTTMUSP00000054213 VEGA | MGI Sequence Detail 910 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(22) UniProt(2)
Polymorphisms SNPs within 2kb(543 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR001604 DNA/RNA non-specific endonuclease
InterPro IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family
InterPro IPR020821 Extracellular Endonuclease, subunit A
InterPro IPR020436 Somatomedin B, chordata
InterPro IPR001212 Somatomedin B domain
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Protein Ontology PR:000007088 ectonucleotide pyrophosphatase/phosphodiesterase family member 2
References (Earliest) J:21382 Narita M, et al., Molecular cloning, expression, and localization of a brain-specific phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from rat brain. J Biol Chem. 1994 Nov 11;269(45):28235-42
(Latest) J:202516 Grisanti L, et al., Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis. J Invest Dermatol. 2013 Oct;133(10):2332-9
All references(73)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory