37 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Enpp2tm1.1Bout/Enpp2tm1.1Bout involves: 129S2/SvPas * C57BL/6	prenatal lethality, complete penetrance	J:123726
Enpp2tm1.1Vart/Enpp2tm1.1Vart B6.Cg-Enpp2tm1.1Vart/Flmg	abnormal allantois morphology	J:159118
	abnormal axon extension	J:159118
	abnormal blood circulation	J:159118
	abnormal blood vessel morphology	J:159118
	abnormal chorionic plate morphology	J:159118
	abnormal neural tube morphology	J:134373, J:159118
	abnormal somite development	J:159118
	abnormal trophoblast giant cell morphology	J:159118
	abnormal vasculogenesis	J:134373
	abnormal vitelline vasculature morphology	J:159118
	decreased cell proliferation	J:159118
	embryonic growth retardation	J:159118
	embryonic lethality during organogenesis, complete penetrance	J:134373, J:159118
	failure of chorioallantoic fusion	J:159118
	failure of initiation of embryo turning	J:159118
	increased neural tube apoptosis	J:159118
	irregular heartbeat	J:159118
	open neural tube	J:159118
Enpp2tm1.1Whm/Enpp2tm1.1Whm involves: 129P2/OlaHsd * FVB/N	abnormal blood vessel morphology	J:110324
	abnormal forebrain development	J:110324
	absent vitelline blood vessels	J:110324
	dilated allantois	J:110324
	edema	J:110324
	embryonic growth retardation	J:110324
	embryonic lethality during organogenesis, complete penetrance	J:110324
	failure of chorioallantoic fusion	J:110324
	failure of initiation of embryo turning	J:110324
	kinked neural tube	J:110324
	open neural tube	J:110324
	wavy neural tube	J:110324
Enpp2tm1Lex/Enpp2+ involves: 129S/SvEvBrd * C57BL/6J	abnormal chemokine level	J:103485
	decreased circulating interleukin-6 level	J:103485
	decreased circulating tumor necrosis factor level	J:103485
	decreased susceptibility to endotoxin shock	J:103485
Enpp2tm1Lex/Enpp2tm1Lex involves: 129S/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Enpp2tm1Mmas/Enpp2tm1Mmas involves: 129P2/OlaHsd * C57BL/6N	abnormal visceral endoderm morphology	J:156013
	abnormal visceral yolk sac endoderm morphology	J:156013
	abnormal vitelline vasculature morphology	J:156013
	decreased embryo size	J:156013
	embryonic lethality during organogenesis, complete penetrance	J:156013
	failure of initiation of embryo turning	J:156013
Enpp2tm1Vart/Enpp2tm1Vart B6.Cg-Enpp2tm1Vart/Flmg	no abnormal phenotype detected	J:134373
Enpp2tm1Vart/Enpp2tm1Vart Edil3Tg(Sox2-cre)1Amc/Edil3+ involves: C57BL/6 * CBA	embryonic lethality	J:159118
Enpp2tm1Vart/Enpp2tm1Vart Tg(Tie1-cre)9Ref/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal embryo phenotype	J:159118
	normal mortality/aging	J:159118
Enpp2tm1Whm/Enpp2tm1Whm involves: 129P2/OlaHsd * FVB/N	no abnormal phenotype detected	J:110324