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G0s2
Gene Detail
Symbol

Name
ID
G0s2
G0/G1 switch gene 2
MGI:1316737
Feature Type
protein coding gene
Genetic Map
Chromosome 1
97.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:193272161-193273188 bp, - strand
From Ensembl annotation of GRCm38

  1028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7326  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: G0/G1 switch protein 2
Gene Tree: G0s2

Human
homologs
Human Homolog G0S2, G0/G1 switch 2
NCBI Gene ID 50486
neXtProt AC  NX_P27469
Human Chr (Location)  1q32.2; chr1:209675325-209676390 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit enhanced adipose lipolysis, altered hepatic energy balance and improved high fat diet induced liver steatosis and glucose homeostasis.
 
Interactions
G0s2 interacts with 54 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process apoptotic process, extrinsic apoptotic signaling pathway, ...
Component mitochondrion
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (3)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(85)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) cDNA(85)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000009633 (Evidence)
Entrez Gene14373 (Evidence)
UniGene439721
DFCITC1577732
DoTSDT.534900
NIA Mouse Gene IndexU022222
Consensus CDS ProjectCCDS15636.1
International Mouse Knockout Project StatusG0s2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009633 Ensembl Gene Model | MGI Sequence Detail 1028 C57BL/6J ±  kb
transcript ENSMUST00000009777 Ensembl | MGI Sequence Detail 842 Not Applicable 
polypeptide ENSMUSP00000009777 Ensembl | MGI Sequence Detail 103 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016821 G0/G1 switch protein 2, putative
Protein Ontology PR:000031459 G0/G1 switch protein 2
References
(Earliest) J:51222 Bachner D, et al., Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). Dev Dyn. 1998 Dec;213(4):398-411
(Latest) J:209000 Zhang X, et al., Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes. 2014 Mar;63(3):934-46
All references(30)
Other
accession IDs
MGI:2138179, MGI:2138512

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory