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Cox7a1 Gene Detail
Summary
  • Symbol
    Cox7a1
  • Name
    cytochrome c oxidase subunit 7A1
  • Synonyms
    COX7A, COX7AH, COX7AH, COX7AM
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316714
    NCBI Gene: 12865
  • Gene Overview
    MyGene.info: COX7A1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30184171-30186030 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 17.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316714
protein coding gene Chr7:30184144-30186078 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032004
protein coding gene Chr7:29160096-29161953 (+)
A/J MGP_AJ_G0031981
protein coding gene Chr7:28394658-28396498 (+)
AKR/J MGP_AKRJ_G0031914
protein coding gene Chr7:29122902-29124742 (+)
BALB/cJ MGP_BALBcJ_G0031988
protein coding gene Chr7:28570116-28571956 (+)
C3H/HeJ MGP_C3HHeJ_G0031707
protein coding gene Chr7:29559426-29561283 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032453
protein coding gene Chr7:30094237-30096094 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029504
protein coding gene Chr7:29429991-29431639 (+)
CAST/EiJ MGP_CASTEiJ_G0031041
protein coding gene Chr7:22808487-22810327 (+)
CBA/J MGP_CBAJ_G0031673
protein coding gene Chr7:31548299-31550156 (+)
DBA/2J MGP_DBA2J_G0031825
protein coding gene Chr7:28123590-28125430 (+)
FVB/NJ MGP_FVBNJ_G0031782
protein coding gene Chr7:28235038-28236895 (+)
LP/J MGP_LPJ_G0031906
protein coding gene Chr7:29484249-29486089 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031818
protein coding gene Chr7:30816040-30817894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032482
protein coding gene Chr7:28612979-28614833 (+)
PWK/PhJ MGP_PWKPhJ_G0030768
protein coding gene Chr7:23150646-23152510 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030600
protein coding gene Chr7:19610742-19612540 (+)
WSB/EiJ MGP_WSBEiJ_G0031151
protein coding gene Chr7:28994110-28995974 (+)



Homology
more
  • Human Ortholog
    COX7A1, cytochrome c oxidase subunit 7A1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    COX7A1, cytochrome c oxidase subunit 7A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COX7A, COX7AH, COX7AM
  • Links
    NCBI Gene ID: 1346
    neXtProt AC: NX_P24310
    UniProt: P24310

  • Chr Location
    19q13.12; chr19:36150922-36152869 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cox7a1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some premature death and dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12865 NCBI Gene Model | MGI Sequence Detail 1860 C57BL/6J ±  kb
    transcript NM_009944 RefSeq | MGI Sequence Detail 393 C57BL/6  
    polypeptide P56392 UniProt | EBI | MGI Sequence Detail 80 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005786 cytochrome c oxidase subunit 7A1, mitochondrial
    • InterPro Domains
      IPR039297 Cytochrome c oxidase subunit VII
      IPR003177 Cytochrome c oxidase subunit VIIa, metazoa
      IPR036539 Cytochrome c oxidase, subunit VIIa superfamily
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 73
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:47941 Jaradat SA, et al., Tissue-specific expression and mapping of the Cox7ah gene in mouse (Erratum: 1998;54(3):583-4). Genomics. 1998 May 1;49(3):363-70
    • Latest
      J:247178 Singh R, et al., Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017 May 01;158(5):1217-1230

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory