Cyba
Gene Detail

Symbol Name ID

Cyba cytochrome b-245, alpha polypeptide MGI:1316658

Synonyms

b558, cytochrome beta-558, p22 phox

Feature Type

protein coding gene

Genetic Map

Chromosome 8

71.04 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:122424772-122432940 bp, - strand From Ensembl annotation of GRCm38   8169 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:80  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: cytochrome b558, alpha subunit
Gene Tree: Cyba

Human homologs

Human Homolog		CYBA, cytochrome b-245, alpha polypeptide
NCBI Gene ID		1535
neXtProt AC		NX_P13498
Human Synonyms		p22-PHOX
Human Chr (Location)		16q24; chr16:88709697-88717492 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CYBA

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(6) Chemically induced(1)
 

Mice homozygous for an ENU-induced mutation exhibit defects in balance, absence of otoconia, and an inability of phagocytes to produce bacteria-destroying reactive oxygen species.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	cellular response to organic substance, cytochrome complex assembly, ...
Component	apical plasma membrane, cytoplasm, ...
Function	electron carrier activity, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (56)    Tissues (37)    Images (6)
Theiler Stages: 8, 9, 12, 14, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	24
RT-PCR	15

cDNA source data(84)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(86) cDNA(84) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000006519 (Evidence)
Entrez Gene	13057 (Evidence)
UniGene	271671
DFCI	TC1574417, TC1590971, TC1592822, TC1601856
DoTS	DT.101362035, DT.534805, DT.99863317
NIA Mouse Gene Index	U030350
Consensus CDS Project	CCDS22737.1
International Mouse Knockout Project Status	Cyba

Sequences

Length	Strain/Species
genomic	ENSMUSG00000006519	Ensembl Gene Model | MGI Sequence Detail	8169	C57BL/6J
transcript	ENSMUST00000017604	Ensembl | MGI Sequence Detail	758	Not Applicable
polypeptide	ENSMUSP00000017604	Ensembl | MGI Sequence Detail	192	Not Applicable

All sequences(32) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007732	Cytochrome b558 alpha-subunit
Protein Ontology	PR:000006085	cytochrome b-245 light chain

References

(Earliest) J:51302 Sumimoto H, et al., Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558. Biochem Biophys Res Commun. 1989 Dec 15;165(2):902-6
(Latest) J:185776 Gomes SZ, et al., Expression of NADPH oxidase by trophoblast cells: potential implications for the postimplanting mouse embryo. Biol Reprod. 2012 Feb;86(2):56
All references(50)

Other accession IDs

MGI:3526724