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Cyba Gene Detail
Summary
  • Symbol
    Cyba
  • Name
    cytochrome b-245, alpha polypeptide
  • Synonyms
    b558, cytochrome beta-558, p22 phox
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316658
    NCBI Gene: 13057
Location & Maps
more
  • Sequence Map
    Chr8:122424772-122432940 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8169 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 71.04 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CYBA, cytochrome b-245 alpha chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CYBA, cytochrome b-245 alpha chain
    Orthology source: HGNC, HomoloGene
  • Synonyms
    p22-PHOX
  • Links
    NCBI Gene ID: 1535
    neXtProt AC: NX_P13498

  • Chr Location
    16q24; chr16:88643289-88651085 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CYBA associations

Human Disease Mouse Models
       Cytochrome B(-245), Alpha Subunit; CYBA   OMIM: 608508
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative   OMIM: 233690
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Gene trapped
    6
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for an ENU-induced mutation exhibit defects in balance, absence of otoconia, and an inability of phagocytes to produce bacteria-destroying reactive oxygen species.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006519 Ensembl Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
transcript ENSMUST00000017604 Ensembl | MGI Sequence Detail 758 Not Applicable  
polypeptide ENSMUSP00000017604 Ensembl | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    117 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006085 cytochrome b-245 light chain
  • InterPro Domains
    IPR007732 Cytochrome b558 alpha-subunit
Molecular
Reagents
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  • All nucleic 83
    cDNA 81
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:3526724
References
more
  • Summaries
    All 54
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:51302 Sumimoto H, et al., Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558. Biochem Biophys Res Commun. 1989 Dec 15;165(2):902-6
  • Latest
    J:229333 Youn JY, et al., Role of vascular oxidative stress in obesity and metabolic syndrome. Diabetes. 2014 Jul;63(7):2344-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory