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Cyba
Gene Detail
 Symbol
Name
ID
Cyba
cytochrome b-245, alpha polypeptide
MGI:1316658
Synonyms b558, cytochrome beta-558, p22 phox
Feature Type protein coding gene
Genetic Map
Chromosome 8
71.04 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:122424772-122432940 bp, - strand
From Ensembl annotation of GRCm38

  8169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome b558, alpha subunit
Gene Tree: Cyba

Human
homologs
Human Homolog CYBA, cytochrome b-245, alpha polypeptide
NCBI Gene ID 1535
neXtProt AC  NX_P13498
Human Synonyms  p22-PHOX
Human Chr (Location)  16q24; chr16:88643289-88651084 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CYBA
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced mutation exhibit defects in balance, absence of otoconia, and an inability of phagocytes to produce bacteria-destroying reactive oxygen species.
 
Interactions
Cyba interacts with 2 markers (Mir96, Mir328)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cellular response to organic substance, cytochrome complex assembly, ...
Component apical plasma membrane, cytoplasm, ...
Function electron carrier activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (56)    Tissues (37)    Images (6)
Theiler Stages: 8, 9, 12, 14, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 24
RT-PCR 15
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) cDNA(81) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000006519 (Evidence)
Entrez Gene13057 (Evidence)
UniGene271671
DFCITC1574417, TC1590971, TC1592822, TC1601856
DoTSDT.101362035, DT.534805, DT.99863317
NIA Mouse Gene IndexU030350
Consensus CDS ProjectCCDS22737.1
International Mouse Knockout Project StatusCyba
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006519 Ensembl Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
transcript ENSMUST00000017604 Ensembl | MGI Sequence Detail 758 Not Applicable 
polypeptide ENSMUSP00000017604 Ensembl | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007732 Cytochrome b558 alpha-subunit
Protein Ontology PR:000006085 cytochrome b-245 light chain
References (Earliest) J:51302 Sumimoto H, et al., Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558. Biochem Biophys Res Commun. 1989 Dec 15;165(2):902-6
(Latest) J:210088 Kassan M, et al., Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H972-80
All references(54)
Other
accession IDs
MGI:3526724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory