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Cyba Gene Detail
Summary
  • Symbol
    Cyba
  • Name
    cytochrome b-245, alpha polypeptide
  • Synonyms
    b558, cytochrome beta-558, p22 phox
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316658
    NCBI Gene: 13057
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:122424776-122432930 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8155 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 71.04 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CYBA, cytochrome b-245 alpha chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CYBA, cytochrome b-245 alpha chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p22-PHOX
  • Links
    NCBI Gene ID: 1535
    neXtProt AC: NX_P13498
    UniProt: P13498

  • Chr Location
    16q24.2; chr16:88643289-88651084 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CYBA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit defects in balance, absence of otoconia, and an inability of phagocytes to produce bacteria-destroying reactive oxygen species.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061846 VEGA Gene Model | MGI Sequence Detail 8155 C57BL/6J ±  kb
    transcript OTTMUST00000150909 VEGA | MGI Sequence Detail 744 Not Applicable  
    polypeptide OTTMUSP00000078268 VEGA | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      117 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 81
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3526724
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:51302 Sumimoto H, et al., Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558. Biochem Biophys Res Commun. 1989 Dec 15;165(2):902-6
    • Latest
      J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory