About   Help   FAQ
Cyba
Gene Detail
Symbol

Name
ID
Cyba
cytochrome b-245, alpha polypeptide
MGI:1316658
Synonyms
b558, cytochrome beta-558, p22 phox
Feature Type
protein coding gene
Genetic Map
Chromosome 8
71.04 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:122424772-122432940 bp, - strand
From Ensembl annotation of GRCm38

  8169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYBA
Protein SuperFamily: cytochrome b558, alpha subunit
Gene Tree: Cyba

Human
homologs
CYBA, cytochrome b-245, alpha polypeptide
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1535
neXtProt AC: NX_P13498

Human Synonyms: p22-PHOX

Human Chr (Location): 16q24; chr16:88643289-88651085 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CYBA

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced mutation exhibit defects in balance, absence of otoconia, and an inability of phagocytes to produce bacteria-destroying reactive oxygen species.
 
Interactions
Cyba interacts with 2 markers (Mir96, Mir328)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process cellular response to organic substance, cytochrome complex assembly, ...
Component apical plasma membrane, cytoplasm, ...
Function electron carrier activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (56)    Tissues (38)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 24
RT-PCR 15
cDNA source data(81)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cyba ; ZFIN cyba    NEW 
Molecular
reagents
All nucleic(83) cDNA(81) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000006519 (Evidence)
Entrez Gene 13057 (Evidence)
UniGene 271671
DFCI TC1601856, TC1592822, TC1590971, TC1574417
DoTS DT.101362035, DT.99863317, DT.534805
NIA Mouse Gene Index U030350
Consensus CDS Project CCDS22737.1
International Mouse Phenotyping Consortium Status Cyba
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006519 Ensembl Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
transcript ENSMUST00000017604 Ensembl | MGI Sequence Detail 758 Not Applicable 
polypeptide ENSMUSP00000017604 Ensembl | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007732 Cytochrome b558 alpha-subunit
Protein Ontology PR:000006085 cytochrome b-245 light chain
References
(Earliest) J:51302 Sumimoto H, et al., Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558. Biochem Biophys Res Commun. 1989 Dec 15;165(2):902-6
(Latest) J:210088 Kassan M, et al., Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H972-80
All references(54)
Other
accession IDs
MGI:3526724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory