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Cyba Gene Detail
Summary
  • Symbol
    Cyba
  • Name
    cytochrome b-245, alpha polypeptide
  • Synonyms
    b558, cytochrome beta-558, p22 phox
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316658
    NCBI Gene: 13057
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:122424776-122432930 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 71.04 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316658
protein coding gene Chr8:122424771-122432940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034224
protein coding gene Chr8:125961951-125970122 (-)
A/J MGP_AJ_G0034204
protein coding gene Chr8:120748421-120756685 (-)
AKR/J MGP_AKRJ_G0034131
protein coding gene Chr8:124266826-124274991 (-)
BALB/cJ MGP_BALBcJ_G0034198
protein coding gene Chr8:120950213-120958378 (-)
C3H/HeJ MGP_C3HHeJ_G0033909
protein coding gene Chr8:124966395-124974561 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034718
protein coding gene Chr8:130146591-130155179 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031660
protein coding gene Chr8:113584164-113592403 (-)
CAST/EiJ MGP_CASTEiJ_G0033236
protein coding gene Chr8:125044983-125053125 (-)
CBA/J MGP_CBAJ_G0033882
protein coding gene Chr8:134951639-134959808 (-)
DBA/2J MGP_DBA2J_G0034038
protein coding gene Chr8:119940630-119948799 (-)
FVB/NJ MGP_FVBNJ_G0033981
protein coding gene Chr8:119077423-119086827 (-)
LP/J MGP_LPJ_G0034127
protein coding gene Chr8:126089053-126097221 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034028
protein coding gene Chr8:137129298-137137465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034736
protein coding gene Chr8:124451113-124459268 (-)
PWK/PhJ MGP_PWKPhJ_G0032938
protein coding gene Chr8:119759772-119768381 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032778
protein coding gene Chr8:123175558-123183725 (-)
WSB/EiJ MGP_WSBEiJ_G0033352
protein coding gene Chr8:125206129-125214294 (-)



Homology
more
  • Human Ortholog
    CYBA, cytochrome b-245 alpha chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CYBA, cytochrome b-245 alpha chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p22-PHOX
  • Links
    NCBI Gene ID: 1535
    neXtProt AC: NX_P13498
    UniProt: P13498

  • Chr Location
    16q24.2; chr16:88643289-88651084 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit defects in balance, absence of otoconia, and an inability of phagocytes to produce bacteria-destroying reactive oxygen species.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006519 Ensembl Gene Model | MGI Sequence Detail 8155 C57BL/6J ±  kb
    transcript ENSMUST00000017604 Ensembl | MGI Sequence Detail 744 Not Applicable  
    polypeptide ENSMUSP00000017604 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 82
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3526724
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:51302 Sumimoto H, et al., Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558. Biochem Biophys Res Commun. 1989 Dec 15;165(2):902-6
    • Latest
      J:241355 Thomas DC, et al., Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. J Exp Med. 2017 Apr 03;214(4):1111-1128

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory