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Emg1
Gene Detail
Symbol

Name
ID
Emg1
EMG1 nucleolar protein homolog (S. cerevisiae)
MGI:1315195
Synonyms
Grcc2f
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:124704381-124712178 bp, - strand
From VEGA annotation of GRCm38

  7798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EMG1
Gene Tree: Emg1

Human
homologs
EMG1, EMG1 N1-specific pseudouridine methyltransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10436
neXtProt AC: NX_Q92979

Human Synonyms: C2F, Grcc2f, NEP1

Human Chr (Location): 12p13.3; chr12:6970781-6976003 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EMG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(39) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a reporter allele fail to form blastocele and die after E3.5.
 
Interactions
Emg1 interacts with 33 markers (Mir98, Mir130b, Mir141, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process blastocyst development, methylation, ...
Component nucleolus, nucleus, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(133)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase emg1    NEW 
Molecular
reagents
All nucleic(135) Genomic(1) cDNA(134)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000023581 (Evidence)
Ensembl Gene Model ENSMUSG00000004268 (Evidence)
Entrez Gene 14791 (Evidence)
UniGene 6390
DFCI TC1574475
DoTS DT.101204162, DT.101408720, DT.55107705, DT.94392700
NIA Mouse Gene Index U027844
EC 2.1.1.-
Consensus CDS Project CCDS20524.1
International Mouse Phenotyping Consortium Status Emg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023581 VEGA Gene Model | MGI Sequence Detail 7798 C57BL/6J ±  kb
transcript OTTMUST00000057562 VEGA | MGI Sequence Detail 1034 Not Applicable 
polypeptide OTTMUSP00000027768 VEGA | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005304 Ribosomal biogenesis, methyltransferase, EMG1/NEP1
Protein Ontology PR:000029642 ribosomal RNA small subunit methyltransferase NEP1
References
(Earliest) J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory