Emg1
Gene Detail

Symbol Name ID

Emg1 EMG1 nucleolar protein homolog (S. cerevisiae) MGI:1315195

Synonyms

Grcc2f

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:124704381-124712178 bp, - strand From VEGA annotation of GRCm38   7798 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Emg1

Human homologs

Human Homolog		EMG1, EMG1 nucleolar protein homolog (S. cerevisiae)
NCBI Gene ID		10436
neXtProt AC		NX_Q92979
Human Synonyms		C2F, Grcc2f, NEP1
Human Chr (Location)		12p13.3; chr12:7079944-7085165 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EMG1

Alleles and phenotypes

All alleles(43) : Targeted(4) Gene trapped(39)
 

Mice homozygous for a reporter allele fail to form blastocele and die after E3.5.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	methylation, ribosome biogenesis, ...
Component	nucleus
Function	methyltransferase activity, RNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(133)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(135) Genomic(1) cDNA(134)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000023581 (Evidence)
Ensembl Gene Model	ENSMUSG00000004268 (Evidence)
Entrez Gene	14791 (Evidence)
UniGene	6390
DFCI	TC1574475
DoTS	DT.101204162, DT.101408720, DT.55107705, DT.94392700
NIA Mouse Gene Index	U027844
EC	2.1.1.-
Consensus CDS Project	CCDS20524.1
International Mouse Knockout Project Status	Emg1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023581	VEGA Gene Model | MGI Sequence Detail	7798	C57BL/6J
transcript	OTTMUST00000057562	VEGA | MGI Sequence Detail	1034	Not Applicable
polypeptide	OTTMUSP00000027768	VEGA | MGI Sequence Detail	244	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005304	Ribosomal biogenesis, methyltransferase, EMG1/NEP1
Protein Ontology	PR:000034939	ribosomal RNA small subunit methyltransferase NEP1

References

(Earliest) J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)