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Hipk3
Gene Detail
 Symbol
Name
ID
Hipk3
homeodomain interacting protein kinase 3
MGI:1314882
Synonyms DYRK6, FIST3
Feature Type protein coding gene
Genetic Map
Chromosome 2
54.74 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr2:104426481-104494446 bp, - strand
From VEGA annotation of GRCm38

  67966 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55923  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hipk3

Human
homologs
Human Homolog HIPK3, homeodomain interacting protein kinase 3
NCBI Gene ID 10114
neXtProt AC  NX_Q9H422
Human Synonyms  DYRK6, FIST3, PKY, YAK1
Human Chr (Location)  11p13; chr11:33256672-33357023 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit impaired insulin secretion and glucose tolerance.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process apoptotic process, mRNA transcription, ...
Component cytoplasm, nucleus, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (131)    Tissues (14)    Images (24)
Theiler Stages: 15, 23
Assay TypeResults
RNA in situ 131
cDNA source data(108)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(110) cDNA(109) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014944 (Evidence)
Ensembl Gene ModelENSMUSG00000027177 (Evidence)
Entrez Gene15259 (Evidence)
UniGene257925
DoTSDT.110682723, DT.526829
NIA Mouse Gene IndexU043839
EC2.7.11.1
Consensus CDS ProjectCCDS16489.1
International Mouse Knockout Project StatusHipk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014944 VEGA Gene Model | MGI Sequence Detail 67966 C57BL/6J ±  kb
transcript OTTMUST00000035488 VEGA | MGI Sequence Detail 3651 Not Applicable 
polypeptide OTTMUSP00000015890 VEGA | MGI Sequence Detail 1213 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008568 homeodomain-interacting protein kinase 3
References (Earliest) J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
(Latest) J:194563 Shojima N, et al., Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice. Diabetologia. 2012 Dec;55(12):3318-30
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory