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Hipk3 Gene Detail
Summary
  • Symbol
    Hipk3
  • Name
    homeodomain interacting protein kinase 3
  • Synonyms
    DYRK6, FIST3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314882
    NCBI Gene: 15259
  • Gene Overview
    MyGene.info: HIPK3
Location & Maps
more
  • Sequence Map
    Chr2:104426481-104494446 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67966 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HIPK3, homeodomain interacting protein kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HIPK3, homeodomain interacting protein kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DYRK6, FIST3, PKY, YAK1
  • Links
    NCBI Gene ID: 10114
    neXtProt AC: NX_Q9H422

  • Chr Location
    11p13; chr11:33256672-33357023 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55923
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HIPK3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Hipk3
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit impaired insulin secretion and glucose tolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014944 VEGA Gene Model | MGI Sequence Detail 67966 C57BL/6J ±  kb
transcript OTTMUST00000035488 VEGA | MGI Sequence Detail 3651 Not Applicable  
polypeptide OTTMUSP00000015890 VEGA | MGI Sequence Detail 1213 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    287 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008568 homeodomain-interacting protein kinase 3
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 110
    cDNA 109
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
  • Latest
    J:194563 Shojima N, et al., Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice. Diabetologia. 2012 Dec;55(12):3318-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory