Hipk3
Gene Detail

Symbol Name ID

Hipk3 homeodomain interacting protein kinase 3 MGI:1314882

Synonyms

DYRK6, FIST3

Feature Type

protein coding gene

Genetic Map

Chromosome 2

54.74 cM
Detailed Genetic Map ± 1 cM

Sequence Map

Chr2:104426481-104494446 bp, - strand From VEGA annotation of GRCm38   67966 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55923  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Hipk3

Human homologs

Human Homolog		HIPK3, homeodomain interacting protein kinase 3
NCBI Gene ID		10114
neXtProt AC		NX_Q9H422
Human Synonyms		DYRK6, FIST3, PKY, YAK1
Human Chr (Location)		11p13; chr11:33279168-33375939 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(2) Gene trapped(7)
 

Mice homozygous for a gene trap allele exhibit impaired insulin secretion and glucose tolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	apoptotic process, mRNA transcription, ...
Component	cytoplasm, nucleus, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (131)    Tissues (14)    Images (24)
Theiler Stages: 15, 23

Assay Type	Results
RNA in situ	131

cDNA source data(106)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(108) cDNA(107) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014944 (Evidence)
Ensembl Gene Model	ENSMUSG00000027177 (Evidence)
Entrez Gene	15259 (Evidence)
UniGene	257925
DoTS	DT.110682723, DT.526829
NIA Mouse Gene Index	U043839
EC	2.7.11.1
Consensus CDS Project	CCDS16489.1
International Mouse Knockout Project Status	Hipk3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014944	VEGA Gene Model | MGI Sequence Detail	67966	C57BL/6J
transcript	OTTMUST00000035488	VEGA | MGI Sequence Detail	3651	Not Applicable
polypeptide	OTTMUSP00000015890	VEGA | MGI Sequence Detail	1213	Not Applicable

All sequences(44) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(190 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008568	homeodomain-interacting protein kinase 3

References

(Earliest) J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
(Latest) J:194563 Shojima N, et al., Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice. Diabetologia. 2012 Dec;55(12):3318-30
All references(38)