About   Help   FAQ
Hipk2
Gene Detail
Symbol

Name
ID
Hipk2
homeodomain interacting protein kinase 2
MGI:1314872
Synonyms
1110014O20Rik, B230339E18Rik, Stank
Feature Type
protein coding gene
Genetic Map
Chromosome 6
17.85 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:38694390-38876165 bp, - strand
From VEGA annotation of GRCm38

  181776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68766  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hipk2

Human
homologs
Human Homolog HIPK2, homeodomain interacting protein kinase 2
NCBI Gene ID 28996
neXtProt AC  NX_Q9H2X6
Human Synonyms  PRO0593
Human Chr (Location)  7q32-q34; chr7:139561570-139777894 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display decreased apoptosis and increased neuron numbers in the trigeminal ganglion.
 
Interactions
Hipk2 interacts with 384 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process adult locomotory behavior, adult walking behavior, ...
Component cytoplasm, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (154)    Tissues (144)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
Northern blot 8
Western blot 2
RT-PCR 3
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(14) Primer pair(2) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000034370 (Evidence)
Ensembl Gene ModelENSMUSG00000061436 (Evidence)
Entrez Gene15258 (Evidence)
DoTSDT.101384952, DT.60118111, DT.87072430, DT.91333823, DT.91335367, DT.91352667, DT.91416521, DT.97409666
NIA Mouse Gene IndexU027194, U027195, U361239
EC2.7.11.1
Consensus CDS ProjectCCDS20017.2, CCDS51752.1
International Mouse Knockout Project StatusHipk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034370 VEGA Gene Model | MGI Sequence Detail 181776 C57BL/6J ±  kb
transcript OTTMUST00000087404 VEGA | MGI Sequence Detail 7684 Not Applicable 
polypeptide OTTMUSP00000047473 VEGA | MGI Sequence Detail 1196 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(529 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008567 homeodomain-interacting protein kinase 2
References
(Earliest) J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
(Latest) J:211064 Sjolund J, et al., Identification of Hipk2 as an essential regulator of white fat development. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7373-8
All references(73)
Other
accession IDs
MGI:1915852, MGI:1929609, MGI:2443252

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory