Hipk2
Gene Detail

Symbol Name ID

Hipk2 homeodomain interacting protein kinase 2 MGI:1314872

Synonyms

1110014O20Rik, B230339E18Rik, Stank

Feature Type

protein coding gene

Genetic Map

Chromosome 6

17.85 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:38694390-38876165 bp, - strand From VEGA annotation of GRCm38   181776 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68766  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hipk2

Human homologs

Human Homolog		HIPK2, homeodomain interacting protein kinase 2
NCBI Gene ID		28996
neXtProt AC		NX_Q9H2X6
Human Synonyms		PRO0593
Human Chr (Location)		7q32-q34

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(3)
 

Homozygous null mice display decreased apoptosis and increased neuron numbers in the trigeminal ganglion.

 

Gene Ontology (GO) classifications

All GO classifications: (65 annotations)

Process	adult locomotory behavior, adult walking behavior, ...
Component	centrosome, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (136)    Tissues (127)    Images (14)
Theiler Stages: 15, 16, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	123
Northern blot	8
Western blot	2
RT-PCR	3

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(14) Primer pair(2) Other(1)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000034370 (Evidence)
Ensembl Gene Model	ENSMUSG00000061436 (Evidence)
Entrez Gene	15258 (Evidence)
DoTS	DT.101384952, DT.60118111, DT.87072430, DT.91333823, DT.91335367, DT.91352667, DT.91416521, DT.97409666
NIA Mouse Gene Index	U027194, U027195, U361239
EC	2.7.11.1
Consensus CDS Project	CCDS20017.2, CCDS51752.1
International Mouse Knockout Project Status	Hipk2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034370	VEGA Gene Model | MGI Sequence Detail	181776	C57BL/6J
transcript	OTTMUST00000087404	VEGA | MGI Sequence Detail	7684	Not Applicable
polypeptide	OTTMUSP00000047473	VEGA | MGI Sequence Detail	1196	Not Applicable

All sequences(60) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(501 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008567	homeodomain-interacting protein kinase 2

References

(Earliest) J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
(Latest) J:188015 Rinaldo C, et al., HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. Mol Cell. 2012 Jul 13;47(1):87-98
All references(66)

Other accession IDs

MGI:1915852, MGI:1929609, MGI:2443252