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Rasgrp1
Gene Detail
 Symbol
Name
ID
Rasgrp1
RAS guanyl releasing protein 1
MGI:1314635
Feature Type protein coding gene
Genetic Map
Chromosome 2
59.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:117279993-117343001 bp, - strand
From VEGA annotation of GRCm38

  63009 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rasgrp1

Human
homologs
Human Homolog RASGRP1, RAS guanyl releasing protein 1 (calcium and DAG-regulated)
NCBI Gene ID 10125
neXtProt AC  NX_O95267
Human Synonyms  CALDAG-GEFI, CALDAG-GEFII, hRasGRP1, RASGRP, V
Human Chr (Location)  15q14; chr15:38488101-38564806 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Chemically induced (ENU)(2) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes.
 
Human Diseases Modeled Using Mouse Rasgrp1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process activation of Ras GTPase activity, activation of Rho GTPase activity, ...
Component cell, cytoplasm, ...
Function calcium ion binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (17)    Tissues (5)    Images (9)
Theiler Stages: 21, 23, 25
Assay TypeResults
RNA in situ 15
RT-PCR 2
cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) Genomic(1) cDNA(40) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000015228 (Evidence)
Ensembl Gene ModelENSMUSG00000027347 (Evidence)
Entrez Gene19419 (Evidence)
UniGene42150
DFCITC1587889, TC1600400, TC1609935, TC1651697
DoTSDT.101210636, DT.91376852, DT.99851563
NIA Mouse Gene IndexU023201
Consensus CDS ProjectCCDS16572.1
International Mouse Knockout Project StatusRasgrp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015228 VEGA Gene Model | MGI Sequence Detail 63009 C57BL/6J ±  kb
transcript OTTMUST00000036074 VEGA | MGI Sequence Detail 5229 Not Applicable 
polypeptide OTTMUSP00000016207 VEGA | MGI Sequence Detail 795 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Protein Ontology PR:000013758 RAS guanyl-releasing protein 1
References (Earliest) J:46742 Bottorff D, et al., RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. Mamm Genome. 1999 Apr;10(4):358-61
(Latest) J:209152 Sharma A, et al., Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. 2014 May;35(5):1084-91
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory