Rasgrp1
Gene Detail

Symbol Name ID

Rasgrp1 RAS guanyl releasing protein 1 MGI:1314635

Feature Type

protein coding gene

Genetic Map

Chromosome 2

59.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:117279993-117343001 bp, - strand From VEGA annotation of GRCm38   63009 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rasgrp1

Human homologs

Human Homolog		RASGRP1, RAS guanyl releasing protein 1 (calcium and DAG-regulated)
NCBI Gene ID		10125
neXtProt AC		NX_O95267
Human Synonyms		CALDAG-GEFI, CALDAG-GEFII, hRasGRP1, RASGRP, V
Human Chr (Location)		15q14; chr15:38780302-38857007 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Spontaneous(1)
 

Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes.

 
Human Diseases Modeled Using Mouse Rasgrp1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	activation of Ras GTPase activity, activation of Rho GTPase activity, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	calcium ion binding, guanyl-nucleotide exchange factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (17)    Tissues (5)    Images (9)
Theiler Stages: 21, 23, 25

Assay Type	Results
RNA in situ	15
RT-PCR	2

cDNA source data(39)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(1) cDNA(41) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000015228 (Evidence)
Ensembl Gene Model	ENSMUSG00000027347 (Evidence)
Entrez Gene	19419 (Evidence)
UniGene	42150
DFCI	TC1587889, TC1600400, TC1609935, TC1651697
DoTS	DT.101210636, DT.91376852, DT.99851563
NIA Mouse Gene Index	U023201
Consensus CDS Project	CCDS16572.1
International Mouse Knockout Project Status	Rasgrp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015228	VEGA Gene Model | MGI Sequence Detail	63009	C57BL/6J
transcript	OTTMUST00000036074	VEGA | MGI Sequence Detail	5229	Not Applicable
polypeptide	OTTMUSP00000016207	VEGA | MGI Sequence Detail	795	Not Applicable

All sequences(53) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs within 2kb(317 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand domain pair
InterPro	IPR001895	Guanine-nucleotide dissociation stimulator CDC25
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR008937	Ras guanine nucleotide exchange factor
InterPro	IPR023578	Ras guanine nucleotide exchange factor, domain
InterPro	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Protein Ontology	PR:000013758	RAS guanyl-releasing protein 1

References

(Earliest) J:46742 Bottorff D, et al., RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. Mamm Genome. 1999 Apr;10(4):358-61
(Latest) J:195716 Golec DP, et al., RasGRP1, but not RasGRP3, is required for efficient thymic beta-selection and ERK activation downstream of CXCR4. PLoS One. 2013;8(1):e53300
All references(56)