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Cenpf
Gene Detail
Symbol

Name
ID
Cenpf
centromere protein F
MGI:1313302
Synonyms
6530404A22Rik, Lek1, mitosin
Feature Type
protein coding gene
Genetic Map
Chromosome 1
95.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:189640606-189688086 bp, - strand
From VEGA annotation of GRCm38

  47481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CENPF
Gene Tree: Cenpf

Human
homologs
CENPF, centromere protein F, 350/400kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1063
neXtProt AC: NX_P49454

Human Synonyms: CENF, CILD31, hcp-1, PRO1779

Human Chr (Location): 1q41; chr1:214603179-214664571 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CENPF

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(11) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Cenpf interacts with 355 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process chromosome segregation, metaphase plate congression, ...
Component chromosome, centromeric region, condensed chromosome outer kinetochore, ...
Function dynein binding, protein C-terminus binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (124)    Tissues (115)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 94
Northern blot 21
cDNA source data(146)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cenpf ; ZFIN cenpf    NEW 
Molecular
reagents
All nucleic(148) Genomic(1) cDNA(146) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000035168 (Evidence)
Ensembl Gene Model ENSMUSG00000026605 (Evidence)
Entrez Gene 108000 (Evidence)
UniGene 129746
DFCI TC1597488, TC1609295
DoTS DT.101380922, DT.103567373, DT.489527
NIA Mouse Gene Index U022190
Consensus CDS Project CCDS35820.2
International Mouse Phenotyping Consortium Status Cenpf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035168 VEGA Gene Model | MGI Sequence Detail 47481 C57BL/6J ±  kb
transcript OTTMUST00000089577 VEGA | MGI Sequence Detail 11130 Not Applicable 
polypeptide OTTMUSP00000048974 VEGA | MGI Sequence Detail 2997 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(5) UniProt(12)
Polymorphisms
RFLP(1) : SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019513 Centromere protein Cenp-F, leucine-rich repeat-containing domain
InterPro IPR018463 Centromere protein Cenp-F, N-terminal
InterPro IPR018302 Centromere protein Cenp-F, Rb protein-binding domain
References
(Earliest) J:124853 Zhu X, et al., The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization. J Biol Chem. 1995 Aug 18;270(33):19545-50
(Latest) J:210591 Aytes A, et al., Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell. 2014 May 12;25(5):638-51
All references(51)
Other
accession IDs
MGI:1344369, MGI:1915046, MGI:2138210

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory