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Cenpf Gene Detail
Summary
  • Symbol
    Cenpf
  • Name
    centromere protein F
  • Synonyms
    6530404A22Rik, Lek1, mitosin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313302
    NCBI Gene: 108000
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:189372803-189420283 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 95.03 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313302
 protein coding gene Chr1:189372803-189420302 (-)
129S1/SvImJ ENSMUSG00200003463
 protein coding gene Chr1:187138858-187186335 (-)
A/J ENSMUSG00195007642
 protein coding gene Chr1:186717163-186764652 (-)
AKR/J ENSMUSG00220004820
 protein coding gene Chr1:185964502-186011980 (-)
BALB/cJ ENSMUSG00180017277
 protein coding gene Chr1:186784529-186832004 (-)
C3H/HeJ ENSMUSG00175021601
 protein coding gene Chr1:186970737-187018217 (-)
C57BL/6NJ ENSMUSG00215012652
 protein coding gene Chr1:186192053-186239535 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015035
 protein coding gene Chr1:179442674-179490052 (-)
CAST/EiJ ENSTCUG00005002026
 protein coding gene Chr1:184752855-184800754 (-)
CBA/J ENSMUSG00210003277
 protein coding gene Chr1:186638472-186685982 (-)
DBA/2J ENSMUSG00185033809
 protein coding gene Chr1:191251618-191299133 (-)
FVB/NJ ENSMUSG00205003420
 protein coding gene Chr1:185636309-185683788 (-)
JF1/MsJ ENSUMUG00000005156
 protein coding gene Chr1:190225382-190273247 (-)
LP/J ENSMUSG00230022872
 protein coding gene Chr1:190781621-190829101 (-)
NOD/ShiLtJ ENSMUSG00190031233
 protein coding gene Chr1:186612993-186660471 (-)
NZO/HlLtJ ENSMUSG00225015814
 protein coding gene Chr1:194544352-194591836 (-)
PWK/PhJ ENSLUMG00010006140
 protein coding gene Chr1:185471330-185518951 (-)
SPRET/EiJ ENSMSPG00010022630
 protein coding gene Chr1:189018882-189066921 (-)
WSB/EiJ ENSIUOG00005004183
 protein coding gene Chr1:185973491-186021168 (-)



Homology
more
  • Human Ortholog
    CENPF, centromere protein F
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPF, centromere protein F
  • Synonyms
    CENF, CILD31, hcp-1, PRO1779, STROMS
  • Links
    NCBI Gene ID: 1063
    UniProt: P49454

  • Chr Location
    1q41; chr1:214603172-214664574 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cenpf mouse models; 1 with human CENPF associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Surprisingly, mice homozygous for any of three endonuclease-mediated mutations that specifically disrupt different domains of CENPF important for mitosis and mitochondrial regulation are viable, fertile and reach adulthood without any apparent phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    121
  • cDNA Data
    147
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026605 Ensembl Gene Model | MGI Sequence Detail 47481 C57BL/6J ±  kb
    transcript ENSMUST00000171929 Ensembl | MGI Sequence Detail 11130 Not Applicable  
    polypeptide ENSMUSP00000129738 Ensembl | MGI Sequence Detail 2997 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR043513 Centromere protein Cenp-F
      IPR019513 Centromere protein Cenp-F, leucine-rich repeat-containing domain
      IPR018463 Centromere protein Cenp-F, N-terminal
      IPR018302 Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain
    • GlyGen
      E9Q3P4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 151
      Genomic 1
      cDNA 147
      Primer pair 2
      Other 1
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1344369, MGI:1915046, MGI:2138210
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:124762 Zhu X, et al., Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. Mol Cell Biol. 1995 Sep;15(9):5017-29
    • Latest
      J:382756 Zhou S, et al., hnRNPM cooperates with BCAS2 to modulate alternative splicing during oocyte development. Nat Commun. 2026 Feb 12;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory