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Cenpf Gene Detail
Summary
  • Symbol
    Cenpf
  • Name
    centromere protein F
  • Synonyms
    6530404A22Rik, Lek1, mitosin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313302
    NCBI Gene: 108000
  • Gene Overview
    MyGene.info: CENPF
Location & Maps
more
  • Sequence Map
    Chr1:189640606-189688086 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47481 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 95.03 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CENPF, centromere protein F
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CENPF, centromere protein F
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CENF, CILD31, hcp-1, PRO1779, STROMS
  • Links
    NCBI Gene ID: 1063
    neXtProt AC: NX_P49454

  • Chr Location
    1q41; chr1:214603179-214664571 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CENPF associations

Human Disease Mouse Models
       Stromme Syndrome; STROMS   OMIM: 243605
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035168 VEGA Gene Model | MGI Sequence Detail 47481 C57BL/6J ±  kb
transcript OTTMUST00000089577 VEGA | MGI Sequence Detail 11130 Not Applicable  
polypeptide OTTMUSP00000048974 VEGA | MGI Sequence Detail 2997 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    248 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    12 Sequences
  • InterPro Domains
    IPR019513 Centromere protein Cenp-F, leucine-rich repeat-containing domain
    IPR018463 Centromere protein Cenp-F, N-terminal
    IPR018302 Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain
Molecular
Reagents
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  • All nucleic 148
    Genomic 1
    cDNA 146
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1344369, MGI:1915046, MGI:2138210
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:124853 Zhu X, et al., The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization. J Biol Chem. 1995 Aug 18;270(33):19545-50
  • Latest
    J:225786 Waters AM, et al., The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes. J Med Genet. 2015 Mar;52(3):147-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory