Cenpf^tm1Dbdr
Targeted Allele Detail

Summary

• Symbol: Cenpf^tm1Dbdr
• Name: centromere protein F; targeted mutation 1, David M Bader
• MGI ID: MGI:5467564
• Synonyms: CENP-F^loxP
• Gene: Cenpf Location: Chr1:189372803-189420283 bp, - strand Genetic Position: Chr1, 95.03 cM
• Alliance: Cenpf^tm1Dbdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185133
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted flanking exons 1 to 5. The floxed region contains functional binding domains for synthaxin 4, Hook2, and Snap25. (J:185133)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cenpf Mutation: 109 strains or lines available

References

• Original: J:185133 Dees E, et al., Cardiac-specific deletion of the microtubule-binding protein CENP-F causes dilated cardiomyopathy. Dis Model Mech. 2012 Jul;5(4):468-80
• All: 3 reference(s)