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Chrd
Gene Detail
 Symbol
Name
ID
Chrd
chordin
MGI:1313268
Synonyms Chd
Feature Type protein coding gene
Genetic Map
Chromosome 16
12.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:20733127-20742384 bp, + strand
From VEGA annotation of GRCm38

  9258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chordin
Gene Tree: Chrd

Human
homologs
Human Homolog CHRD, chordin
NCBI Gene ID 8646
neXtProt AC  NX_Q9H2X0
Human Chr (Location)  3q27; chr3:184380073-184389829 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation show some death prior to embryonic day 8.5, but most die perinatally with abnormalities of the skull, malformations of cervical and thoracic vertebrae, cardiovascular defects, and absence of parathyroid and thymus.
 
Human Diseases Modeled Using Mouse Chrd (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Chrd interacts with 110 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process BMP signaling pathway involved in spinal cord dorsal/ventral patterning, central nervous system development, ...
Component extracellular region, extracellular space
Function heparin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (233)    Tissues (193)    Images (54)
Theiler Stages: 5, 9, 10, 11, 12, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 200
Northern blot 12
RT-PCR 21
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(26) Primer pair(4) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021018 (Evidence)
Ensembl Gene ModelENSMUSG00000006958 (Evidence)
Entrez Gene12667 (Evidence)
UniGene20457
DFCITC1581816, TC1689697
DoTSDT.101242567, DT.101724999, DT.60103555, DT.97363959
NIA Mouse Gene IndexU016933
Consensus CDS ProjectCCDS28059.1
International Mouse Knockout Project StatusChrd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021018 VEGA Gene Model | MGI Sequence Detail 9258 C57BL/6J ±  kb
transcript OTTMUST00000049687 VEGA | MGI Sequence Detail 3275 Not Applicable 
polypeptide OTTMUSP00000023072 VEGA | MGI Sequence Detail 948 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(13) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016353 Chordin
InterPro IPR010895 CHRD
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000000010 chordin
References (Earliest) J:46641 Rhinn M, et al., Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 1998 Mar;125(5):845-56
(Latest) J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All references(97)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory