Chrd
Gene Detail

Symbol Name ID

Chrd chordin MGI:1313268

Synonyms

Chd

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:20733127-20742384 bp, + strand From VEGA annotation of GRCm38   9258 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chordin
Gene Tree: Chrd

Human homologs

Human Homolog		CHRD, chordin
NCBI Gene ID		8646
neXtProt AC		NX_Q9H2X0
Human Chr (Location)		3q27; chr3:184097861-184107617 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a targeted null mutation show some death prior to embryonic day 8.5, but most die perinatally with abnormalities of the skull, malformations of cervical and thoracic vertebrae, cardiovascular defects, and absence of parathyroid and thymus.

 
Human Diseases Modeled Using Mouse Chrd (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	BMP signaling pathway involved in spinal cord dorsal/ventral patterning, central nervous system development, ...
Component	extracellular region, extracellular space
Function	heparin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (58 records)
Data Summary: Results (231)    Tissues (191)    Images (53)
Theiler Stages: 5, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	198
Northern blot	12
RT-PCR	21

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(26) Primer pair(4) Other(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021018 (Evidence)
Ensembl Gene Model	ENSMUSG00000006958 (Evidence)
Entrez Gene	12667 (Evidence)
UniGene	20457
DFCI	TC1581816, TC1689697
DoTS	DT.101242567, DT.101724999, DT.60103555, DT.97363959
NIA Mouse Gene Index	U016933
Consensus CDS Project	CCDS28059.1
International Mouse Knockout Project Status	Chrd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021018	VEGA Gene Model | MGI Sequence Detail	9258	C57BL/6J
transcript	OTTMUST00000049687	VEGA | MGI Sequence Detail	3275	Not Applicable
polypeptide	OTTMUSP00000023072	VEGA | MGI Sequence Detail	948	Not Applicable

All sequences(41) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016353	Chordin
InterPro	IPR010895	CHRD
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000000010	chordin

References

(Earliest) J:46641 Rhinn M, et al., Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 1998 Mar;125(5):845-56
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(94)