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Chrd
Gene Detail
Symbol

Name
ID
Chrd
chordin
MGI:1313268
Synonyms
Chd
Feature Type
protein coding gene
Genetic Map
Chromosome 16
12.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:20733127-20742384 bp, + strand
From VEGA annotation of GRCm38

  9258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHRD
Protein SuperFamily: chordin
Gene Tree: Chrd

Human
homologs
CHRD, chordin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8646
neXtProt AC: NX_Q9H2X0

Human Chr (Location): 3q27; chr3:184380073-184389835 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation show some death prior to embryonic day 8.5, but most die perinatally with abnormalities of the skull, malformations of cervical and thoracic vertebrae, cardiovascular defects, and absence of parathyroid and thymus.
 
Human Diseases Modeled in Mice Using Chrd (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Chrd interacts with 110 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (64 records)
Data Summary: Results (246)    Tissues (194)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 201
Northern blot 24
RT-PCR 21
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chrd ; ZFIN chd    NEW 
Molecular
reagents
All nucleic(39) cDNA(27) Primer pair(4) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021018 (Evidence)
Ensembl Gene Model ENSMUSG00000006958 (Evidence)
Entrez Gene 12667 (Evidence)
UniGene 20457
DFCI TC1581816, TC1689697
DoTS DT.101242567, DT.101724999, DT.60103555, DT.97363959
NIA Mouse Gene Index U016933
Consensus CDS Project CCDS28059.1
International Mouse Phenotyping Consortium Status Chrd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021018 VEGA Gene Model | MGI Sequence Detail 9258 C57BL/6J ±  kb
transcript OTTMUST00000049687 VEGA | MGI Sequence Detail 3275 Not Applicable 
polypeptide OTTMUSP00000023072 VEGA | MGI Sequence Detail 948 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(23) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016353 Chordin
InterPro IPR010895 CHRD
InterPro IPR001007 VWFC domain
Protein Ontology PR:000000010 chordin
References
(Earliest) J:46641 Rhinn M, et al., Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 1998 Mar;125(5):845-56
(Latest) J:222248 Fossat N, et al., Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development. 2015 Jun 1;142(11):2069-79
All references(100)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory