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Slfn2
Gene Detail
Symbol

Name
ID
Slfn2
schlafen 2
MGI:1313258
Synonyms
Shlf2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
50.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:83065112-83070678 bp, + strand
From VEGA annotation of GRCm38

  5567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133205  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Slfn2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Chemically induced (ENU)(1) Targeted(1)
Genomic Mutations involving Slfn2 (1)
 
Mice homozygous for an ENU-induced allele exhibit increased susceptibility to bacterial and viral infections, reduced T cell numbers, decreased T cell proliferation, and increased apoptosis of activated T cells.
 
Interactions
Slfn2 interacts with 48 markers (Mir125a, Mir132, Mir138-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (1 annotations)
Process negative regulation of cell proliferation
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (1)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000918 (Evidence)
Ensembl Gene Model ENSMUSG00000072620 (Evidence)
Entrez Gene 20556 (Evidence)
UniGene 278689
DFCI TC1584869
DoTS DT.489601
NIA Mouse Gene Index U013077
Consensus CDS Project CCDS25156.1
International Mouse Phenotyping Consortium Status Slfn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000918 VEGA Gene Model | MGI Sequence Detail 5567 C57BL/6J ±  kb
transcript OTTMUST00000001788 VEGA | MGI Sequence Detail 1664 Not Applicable 
polypeptide OTTMUSP00000000855 VEGA | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007421 ATPase, AAA-4
References
(Earliest) J:51308 Schwarz DA, et al., Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity. 1998 Nov;9(5):657-68
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(22)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory